Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Genetic Landscape of Neurodegenerative Disorders
Discussion Leader: Philip De Jager (Columbia University Medical Center, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
Alison Goate (Icahn School of Medicine at Mount Sinai, United States)
"The Genetic Landscape of Alzheimer's Disease and How This Informs Disease Mechanism"
8:50 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Advances in Genetics and Genomic Approaches to Neurodegenerative Disease
Discussion Leader: John Hardy (UCL Queen Square Institute of Neurology, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Philip De Jager (Columbia University Medical Center, United States)
"Deconstructing the Cellular Communities that Drive Trajectories to Alzheimer's Disease and Alternative Brain Aging"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Mie Rizig (University College London, United Kingdom)
"The Significance of Genetic Diversity: Insights from Researching the Genetics of Parkinson's Disease in Africans"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Sarah Marzi (King's College London, United Kingdom)
"Epigenetic Signatures of Genetic Risk in Alzheimer's Disease"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, United States)
"Single Cell Dissection of Dementia Pathogenesis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Hemali Phatnani (Columbia University/New York Genome Center, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Contribution of Aging to Neurodegenerative Disease
Discussion Leader: Hemali Phatnani (Columbia University/New York Genome Center, United States)
6:00 pm - 6:20 pm
Giovanna Mallucci (Altos Labs, United Kingdom)
"Boosting Resilience to Prevent Neurodegeneration"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Catherine Kaczorowski (University of Michigan, United States)
"Using Complex Genetics in Mice to Unlock the Secrets of Cognitive Resilience"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Ian Guldner (Stanford University, United States)
"Age-Related Protein Turnover Aberrations Revealed by New Protein Tagging Models"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Frontotemporal Dementia and ALS Mechanistic Updates
Discussion Leader: Michael Ward (National Institutes of Health, United States)
9:00 am - 9:20 am
Christian Haass (Ludwig Maximilians University of Munich, Germany)
"Cellular Mechanisms of Late-Onset Alzheimer’s Disease Risk Variants"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Philip Wong (Johns Hopkins Medicine, United States)
"TDP-43: Pathogenic Mechanism, Presymptomatic Fluid Biomarker and Therapeutic Strategy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jan Veldink (Department of Neurology, University Medical Center Utrecht, The Netherlands, The Netherlands)
"How DNA Research in All ALS Patients Will Change the Course of the Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Parkinson’s Disease: Mechanistic Updates
Discussion Leader: Mark Cookson (National Institute on Aging, NIH, United States)
6:00 pm - 6:20 pm
Tim Bartels (University College London / Dementia Research Institute, United Kingdom)
"Peripheral Immune Modulators in Body-First Parkinson’s Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sonia Gandhi (UCL & The Francis Crick Institute, United Kingdom)
"Single Cell and Single Molecule Approaches to Map Early Mechanisms in Parkinson's Brain and Cell Models"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Short Talk Selected from Poster Abstracts
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Emil Gustavsson (University College London, United Kingdom)
"Utilizing Long-Read RNA Sequencing to Enhance Insight and Improve Therapeutic Targets for Neurodegenerative Disease-Linked Loci"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alzheimer’s Disease: Mechanistic Updates
Discussion Leader: Bart De Strooper (VIB and KU Leuven, Belgium)
9:00 am - 9:20 am
Yakeel Quiroz (Massachusetts General Hospital, United States)
"Charting the Path for Early Diagnosis and Prevention of Alzheimer’s Disease: Findings from the Colombia-Boston (COLBOS) Biomarker Study"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
David Holtzman (Washington University in St. Louis, United States)
"Role of APOE and the Innate and Adaptive Immune Response in the Setting of Amyloid and Tau Pathology"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Soyon Hong (United Kingdom Dementia Research Institute at University College London, United Kingdom)
"Understanding Neuro-Glia-Immune Crosstalk at the Vulnerable Synapse"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Heneka (Université du Luxembourg, Luxembourg)
"Functional and Structural Impact of NLRP3 and NLRP1 Inflammasome Activation on Alzheimer Disease Pathogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tauopathies: Mechanistic Updates
Discussion Leader: David Holtzman (Washington University in St. Louis, United States)
6:00 pm - 6:20 pm
Rene Frank (University of Leeds, United Kingdom)
"In-Tissue Molecular Architecture in Alzheimer's Disease Post-mortem Brain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Li Gan (Weill Cornell Medicine, United States)
"Uncover Mechanisms of Tauopathy in Human iPSC Model"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Short Talk Selected from Poster Abstracts
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Andrew Yoo (Washington University School of Medicine, United States)
"Modeling Age-Associated Neurodegeneration of Late-Onset Disorders via Direct Neuronal Reprogramming"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Biomarkers, Theranostics and Models
Discussion Leader: Stephanie Fradette (Biogen, United States)
9:00 am - 9:30 am
Henrik Zetterberg (UCL, United Kingdom)
"Biomarkers in Neurodegenerative Diseases"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Elisa Konofagou (Columbia University, United States)
"Ultrasound-Mediated Immunomodulation and Drug Delivery in Neurodegerative Disease"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel Therapeutic Approaches
Discussion Leader: Eric Karran (Eli Lilly, United Kingdom)
6:00 pm - 6:20 pm
Stephanie Fradette (Biogen, United States)
"Antisense Oligonucelotide (ASO) Therapy Trials in Amyotrophic Lateral Sclerosis (ALS)"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Stefan Pulst (University of Utah, United States)
"Targeting the ATXN2/STAU1 Complex in Cerebellar and Motor Neuron Degeneration"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Adrian Krainer (Cold Spring Harbor Laboratory, United States)
"Advances in Splice-Correction Therapies for Spinal Muscular Atrophy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Miranda Orr (Wake Forest University School of Medicine, United States)
"Senescent Cells as a Therapeutic Target for Neurodegenerative Diseases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure