Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Proliferation and Genome Stability
Discussion Leader: Martine Roussel (St. Jude Children's Research Hospital, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
Guillermina Lozano (University of Texas MD Anderson Cancer Center, USA)
"p53 Missense Mutations and Cancer"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Peter Sicinski (Dana-Farber Cancer Institute, USA)
"Targeting Cell Cycle Proteins in Cancer Treatment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, USA)
"Mechanisms Driving Rapid Genome Evolution"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cyclin Dependent Kinases and Their Inhibitors
Discussion Leader: Michele Pagano (New York University School of Medicine / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 am
Jane Endicott (Northern Institute for Cancer Research, Newcastle University, United Kingdom)
"Mechanistic Insights into CDK Activity Revealed by Comparative Analysis of CDK-Cyclin Structures"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Bruce Clurman (Fred Hutchinson Cancer Research Center, USA)
"CDK2 and Cancer: Mechanisms and Opportunities"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Seth Rubin (University of California, Santa Cruz, USA)
"p27 Confers Insensitivity to Cdk4/6 Inhibitors"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Tobias Meyer (Stanford University, USA)
"A Parallel Cell-Cycle Entry Pathway with Inverted G1 Signaling and Alternate Point of No Return"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Stephen Dann (Pfizer Oncology Research Discovery, USA)
"Cell Cycle Intervention Beyond Palbociclib: Preclinical Discovery of the CDK2/4/6 Inhibitor PF-06873600"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Jason Sheltzer (Cold Spring Harbor Laboratory, USA)
"Profiling Mischaracterized Anti-Cancer Agents Uncovers the First Potent and Specific Inhibitor of CDK11"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Barbara Jonchere (St. Jude Children's Research Hospital, USA)
"Targeting the RB Pathway in Medulloblastoma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Martine Roussel (St. Jude Children's Research Hospital, USA) and Jeanette Cook (University of North Carolina at Chapel Hill, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Expression
Discussion Leader: Jan Skotheim (Stanford University, USA)
7:30 pm - 7:50 pm
Jacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
"Context Dependent Effects of Epigenetic Regulators in Proliferation and Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Anindya Dutta (University of Virginia, USA)
"Human ORC: Less Replication More Transcription"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Daniel Fisher (Montpellier Institute of Molecular Genetics (IGMM), CNRS, France)
"The Cell Proliferation Antigen Ki-67 Promotes Tumorigenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Kou-Juey Wu (Chang Gung Memorial Hospital at Linkou, Taiwan)
"A New Methyltransferase that Mediates DNA 6mA Modification to Regulate lncRNA Expression and Metastasis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Yiqin Ma (Huntsman Cancer Institute, University of Utah, USA)
"Investigating the Translational Control of the Cell Cycle"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genome Maintenance
Discussion Leader: Anindya Dutta (University of Virginia, USA)
9:00 am - 9:20 am
Stephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"Single-Molecule Studies of Eukaryotic DNA Replication"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Robert Duronio (University of North Carolina at Chapel Hill, USA)
"Chromatin Regulation of DNA Replication"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Yo-Chuen Lin (University of Illinois at Urbana-Champaign, USA)
"Multitalented ORC Proteins: Novel Role in DNA Damage Response"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
Prasad Jallepalli (Memorial Sloan Kettering Cancer Center, USA)
"Human DDK Rescues Stalled Forks and Counteracts Checkpoint Inhibition at Unfired Origins to Complete DNA Replication"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anja Bielinsky (University of Minnesota, USA)
"MCM10 Is Critical for Telomere Maintenance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Gaorav Gupta (The University of North Carolina at Chapel Hill, USA)
"A p53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Tarek Abbas (University of Virginia School of Medicine, USA)
"Re-Replication Induction by DNA Double Strand Breaks"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Sylwia Kabacik (Public Health England, United Kingdom)
"Unravelling the Mechanisms of Aberrant Cell Division Following Exposure to Ionising Radiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitosis and Ploidy
Discussion Leader: Prasad Jallepalli (Memorial Sloan Kettering Cancer Center, USA)
7:30 pm - 7:50 pm
Arne Lindqvist (Karolinska Institutet, Sweden)
"Regulation of G2 Phase"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:05 pm
Introduction by Discussion Leader
8:05 pm - 8:40 pm
Alexander M. Cruickshank Lecture: Angelika Amon (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"How Aneuploidy Causes Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Brian Calvi (Indiana University, USA)
"Regulation of Polyploid Cell Cycle Variations in Development and Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Uri Ben-David (Broad Institute of MIT and Harvard, USA)
"Aneuploidy-Induced Vulnerability of Human Cancer Cells to Inhibition of the Spindle Assembly"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Segregation and Division / Phosphorylation and Ubiquitination
Discussion Leader: Anja Bielinsky (University of Minnesota, USA)
9:00 am - 9:15 am
Dileep Varma (Northwestern University, USA)
"Multiple Kinetochore MAPs Coordinate for Robust End-on Kinetochore-Microtubule Attachments During Mitotic Metaphase"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sara Morais da Silva (University of Cambridge, United Kingdom)
"The Checkpoint Gene Bub3 Moonlights as a Metabolic Regulator"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
David Drutovic (Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Czech Republic)
"The Role of RanGTP-Importin Beta Pathway in Spindle Formation During Mammalian Oocyte Meiosis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kathy Gould (Vanderbilt University School of Medicine, USA)
"Split Decisions: Regulating the End of the Cell Cycle"
10:20 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
Liliana Krasinska (Institute of Molecular Genetics of Montpellier, France)
"Histone H3 Serine-57 Phosphorylation by CHK1 Promotes Responses to DNA Replication Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Zhuqing Li (George Washington University, USA)
"ERK Regulates HIF-1a and Platinum Resistance by Directly Targeting PHD2"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Michael Emanuele (University of North Carolina at Chapel Hill, USA)
"In Silico Identification of APC/C Substrates Reveals Temporal Destruction of Chromatin Regulators During the Cell Cycle"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Tony Ly (University of Edinburgh, United Kingdom)
"Proteomic Analysis of Cell Cycle State Transitions Using PRIMMUS"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Cycle Transitions
Discussion Leader: Hilary Coller (University of California, Los Angeles, USA)
7:30 pm - 7:50 pm
James Ferrell (Stanford University, USA)
"Design Principles of Biochemical Switches, Timers and Oscillators"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jan Skotheim (Stanford University, USA)
"How Cell Growth Triggers Cell Division"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Bart Westendorp (Utrecht University, The Netherlands)
"A Feedback Loop Between E2F and APC/C-Cdh1 Controls Cell Cycle Fates After Induction of DNA Breaks in S/G2-Phase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Amit Tzur (Bar-Ilan University, Israel)
"Cell Cycle Oscillators Underlying Orderly Proteolysis of E2F8 Revealed by Static and Dynamic Cell-Free Systems"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Orlando Arguello-Miranda (University of Texas Southwestern Medical Center, USA)
"Machine Learning Single Cell Analysis of the Transition from Proliferation into Quiescence"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Cycle Entry and Exit
Discussion Leaders: James Ferrell (Stanford University, USA) and Kathy Gould (Vanderbilt University School of Medicine, USA)
9:00 am - 9:20 am
Hilary Coller (University of California, Los Angeles, USA)
"The Role of Autophagy in Quiescence and Wound Healing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sabrina Spencer (University of Colorado Boulder, USA)
"Spontaneously Slow-Cycling Subpopulations of Human Cells Originate from Activation of Stress-Response Pathways"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jennifer Benanti (University of Massachusetts Medical School, USA)
"Crosstalk Between Calcineurin and Hog1 Coordinates the Cell Cycle Response to Stress"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
Sandrine Morlot (Institute of Genetics and Molecular and Cellular Biology (IGBMC), France)
"Excessive rDNA Transcription Drives the Entry into Senescence in Budding Yeast"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Stephen Elledge (Harvard University, USA)
"The Role of SASP in Cancer: Tumor Suppressor or Tumor Promoter?"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Laura Buttitta (University of Michigan, USA)
"Cell Cycle Control and Terminal Differentiation"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Robert Abraham (Pfizer, USA)
"Cyclin-Dependent Kinase Inhibitors as Cancer Therapeutics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Proliferation
Discussion Leader: Jacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
7:30 pm - 7:50 pm
Matthew Vander Heiden (Koch Institute for Integrative Cancer Research at MIT, USA)
"Metabolic Adaptations to Support Proliferation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Maralice Conacci-Sorrell (University of Texas Southwestern Medical Center, USA)
"The Aryl Hydrocarbon Receptor (AHR) Regulates Biomass Production in Proliferative Cells"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Teemu Miettinen (University College London, United Kingdom / Massachusetts Institute of Technology, USA)
"Temporal Control of Mitochondrial ATP Synthesis in Mitosis "
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Joshua Gruber (Stanford University, USA)
"HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Michele Pagano (New York University School of Medicine / Howard Hughes Medical Institute, USA)
"Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Fbxo22-Mediated Degradation of Bach1"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure