Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Breakthroughs in the Studies of Biological Structures
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Aiming for 'Routinely Perfect' Single-Particle Grids"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"3D Structures of the Human Genome"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cutting-Edge Technologies in Specimen Preparation and Data Acquisition
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Many Ways to Skin a Cat: Strategies Used to Solve Structures of 3 Small Asymmetric Membrane Proteins"
9:45 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:55 am
"Cryo-EM Structure of the P Element Transposase Strand Transfer Complex"
10:55 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Scalable Fabrication of High-Quality Graphene Grids for Atomic-Resolution EM"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Trials and Tribulations of an EM Facility Manager"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Strategies to Push the Resolution Limit of Structural Determination
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Cryo-EM of Helical Polymers at Near-Atomic Resolution Yields Some Surprises"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"A New Cryo-EM System for Single Particle Analysis and Electron 3D Crystallography"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"CryoEM Structure of HIV-1 Capsid in Complex with Host Factor Cyclophilin A"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discoveries Beyond Three Dimensional Structures
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Cryo-EM in DNA Replication: From Replication Forks to Replication Factories"
9:45 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Scarce and Unstable Membrane Protein Complexes"
10:25 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Serotonin 5-HT3 Receptors: Structures and Transitions"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Visualizing Integrin Signaling Dynamics"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Selected Poster Presentations: Recent Breakthroughs in 3DEM
4:00 pm - 4:10 pm
"Single Particles from Single Cells Using Shotgun Electron Microscopy"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"Architecture of FA Core Complex"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 4:40 pm
"Assembly and Activation States of the Dot/Icm Type IVB Secretion System"
4:40 pm - 4:45 pm
Discussion
4:45 pm - 4:55 pm
"Conformations of a Heterodimeric ABC Transporter Under Turnover Conditions"
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:10 pm
"Contacts Between the Endoplasmic Reticulum and the Plasma Membrane"
5:10 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
"A Relationship Between Sampling and Resolution in Single-Particle Cryo-EM"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:40 pm
"Energy Dependence of Radiation Damage in Electron Cryomicroscopy"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Assessing the Performance of the K3 Camera"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovations of Instruments and Hardware
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Automated Cryo-EM Sample Preparation Employing Pin-Printing and Jet Vitrification"
9:45 am - 10:00 am
Discussion
10:00 am - 10:25 am
10:25 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Are Further Improvements in Electron Microscopic Hardware Possible and Useful?"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Atomic Resolution 3D Dynamics of Soft Materials: From Low Dose Hologram to Interaction-Free Electron Microscopy"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Advances of Algorithms and Software
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Interpretation of Cryo-EM Maps by Atomic Models"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Recent Developments in Scipion and Xmipp for the Analysis of Single Particles by Electron Microscopy"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Towards Reconstruction Without Particle Picking"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Correlative Methods and Large-Scale Imaging
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Molecular Determinants of Membrane Budding Revealed by Sub-Tomogram Averaging Studies of COPII"
9:45 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Synaptic Vesicle Fusion Under Cryo-ET"
10:25 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Visualizing Mitochondrial Fission Machinery In Situ by Cryo-Electron Tomography"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Cellular Signatures of a 3D Matrix Grown Human Organoid Breast Cancer Progression Model System"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Selected Poster Presentations: New Discoveries by 3DEM
4:00 pm - 4:10 pm
"Graphene Oxide Based Affinity Grids for Cryo-EM Sample Preparation"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"Effects of Alpha-Tubulin Acetylation on Microtubule Structure and Stability"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 4:40 pm
"Liquid-Like Cellular Compartments In Situ : Stress Granules"
4:40 pm - 4:45 pm
Discussion
4:45 pm - 4:55 pm
"Structure and Conformational Heterogeneity of RyR1 in Native Membranes"
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:10 pm
"Structure and Assembly of PVC, an Extracellular Contractile Injection System"
5:10 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
"Superhelical Reconstruction"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:40 pm
"Performance Characteristics and Practical Limitations of the Volta Phase Plate"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Laser Phase Plate for Phase Contrast Transmission Electron Microscopy"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure