SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Invitation to a meal - the beginnings |
| Discussion Leader: Kodi S. Ravichandran (University of Virginia) |
7:40 pm - 8:20 pm | Robert Schlegel (Pennsylvania State University) "Playing hide and seek with phosphatidylserine" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Lynda Stuart (MGH, Boston) "Understanding the complexity: Systems analysis of phagocytosis" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Getting together: Phagocytic receptors and ligands (Session #1) |
| Discussion Leader: Yoshi Nakanishi (Kanazawa University, Japan) |
9:00 am - 9:30 am | Shyra Gardai (National Jewish Medical and Research Center, Denver) "LRP1, Calreticulin and recognition" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Coffee Break / Group Photo |
10:15 am - 10:45 am | Giovanna Chimini (University of Marseille) "Cooperation between engulfment receptors: The case of ABCA1" |
10:45 am - 10:55 am | Discussion |
10:55 am - 11:25 am | Zheng Zhou (Baylor College of Medicine, Houston) "CED-1, vesicle transport and removal of apoptotic cells" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Daeho Park (University of Virginia) "A novel corpse recognition receptor upstream of ELMO" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Zsuzsa Szondy (University of Debrecen) "Role of Tissue Transglutaminase in phagocytosis of apoptotic cells" |
12:25 am - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Getting together: Phagocytic receptors and ligands (Session #2) |
| Discussion Leader: Robert Schlegel (Pennsylvania State University) |
7:30 pm - 8:10 pm | Beth Levine (UT Southwestern, Dallas) "Autophagy-gene dependent clearance of apoptotic cells" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:55 pm | Kazuhide Inoue (Kyushu University, Japan) "UDP, P2Y6 and microglial phagocytosis" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Sandra Franz (Institute for Clinical Immunology, Erlangen, Germany) "Apoptotic cells expose internal membrane derived epitopes on plasma membrane" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Good eating habits: Mechanisms of ingesting and digesting corpses |
| Discussion Leader: Peter Henson (National Jewish Medical Center, Denver) |
9:00 am - 9:35 am | Ray Birge (UMDNJ, New Jersey) "Integrating PS exposure and Rac1 activation during engulfment" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Shige Nagata (Osaka University Medical School, Japan) "Polyarthritis caused by the failure in digesting DNA of corpses" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:45 am | Coffee Break |
10:45 am - 11:15 am | Lars-Peter Erwig (University of Aberdeen, UK) "Regulation of apoptotic cell phagosome maturation" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Lukas Neukomm (University of Zurich) "Identification of negative regulators of engulfment in C. elegans" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Michael Elliott (University of Virginia) "Recruitment signals from apoptotic cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nibbling on the food: Pruning of axons and dendrites by glial cells |
| Discussion Leader: Michael Hengartner (University of Zurich) |
7:30 pm - 8:05 pm | Marc Freeman (University of Massachusetts Medical Center) "Phagocytic removal of apoptotic neurons and axons of injured neurons" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Yoshi Nakanishi (Kanazawa University, Japan) "Isolation of putative ligand for Draper, Drosophila homologue of C. elegans CED-1, responsible for apoptotic cell clearance and axonal pruning" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jeffrey Curtis (University of Michigan) "Interplay between Scavenger Receptors and Mer-TK during apoptotic cell clearance" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | After-the-meal issues - Consequences of Engulfment |
| Discussion Leader: Giovanna Chimini (University of Marseille) |
9:00 am - 9:30 am | Scott Kiss (University of McGill) "Apoptotic cells induce a homeostatic program in phagocytes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Adam Lacy-Hulbert (MIT Center for Cancer Research, Boston) "Kiss and Tell: contact with apoptotic cells and macrophages" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Laszlo Fesus (University of Debracen, Hungary) "Transcriptional regulations in the clearance of apoptotic and autophagic cells" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Nathalie Franc (University College, London) "pallbearer and friends: new players in engulfment" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Dror Mevorach (Hebrew University) "TBA" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Leaving some food behind and the cleanup issues |
| Discussion Leader: Chris Gregory (University of Edinburgh) |
7:30 pm - 8:05 pm | Martin Herrmann (Friedrich-Alexander-University of Erlangen-Nuremberg, Germany) "Apoptosis and autoimmunity: When apoptotic cells break their silence" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:55 pm | Pramod Srivatsava (University of Connecticut, Farmington, CT) "Immunogenicity of cells and proteins, a matter of form" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:30 am - 12:30 pm | 'Test tube to Therapy': Clinical uses of apoptotic cells |
| Discussion Leader: David Peritt (Therakos) |
9:00 am - 9:20 am | David Peritt (Therakos, Inc.) "20 year Anniversary of the clinical use of apoptotic cells" |
9:20 am - 9:25 am | Discussion |
9:25 am - 10:00 am | Mark Barr (USC and Childrens’ Hospital, Los Angeles) "Role of Extracorporeal Photochemotherapy in Solid Organ Transplantation: Sometimes Clinical Efficacy Comes Before Mechanism" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:50 am | James George (University of Alabama at Birmingham) "Apoptotic Cell Therapy in Solid Organ Transplantation: Clinical Outcomes and Animal Models" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Adrian Morreli (University of Pittsburg) "Potential Use Of Apoptotic Cells To Control The Anti-Donor Response In Solid Organ Transplantation" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:50 am | James Ferrara (University of Michigan) "Apoptotic cell modulation of Graft versus Host disease" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Terry Fry (Center for Cancer Research, NCI) "Modulation of Alloreactivity by Extracorporeal Photopheresis: Platform for Tumor-Directed Vaccines" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Desserts / New Developments |
| Discussion Leader: Martin Herrman (Friedrich-Alexander-University, Germany) |
7:30 pm - 8:10 pm | Chris Gregory (University of Edinburgh) "Apoptosis and macrophages: the cancer connection" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 9:00 pm | Peter Henson (National Jewish and Medical Center) "Receptors, ligands and engulfment - current status" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | Closing remarks |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |