Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Autophagy in Immunity and Neurodegenerative Diseases
Session in memory of Beth Levine
Discussion Leader: Anne Simonsen (University of Oslo, Norway)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Vojo Deretic (University of New Mexico Health Sciences Center, United States)
"Autophagy and Atg8-ylation as a Membrane Stress Response"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Katja Simon (University of Oxford, United Kingdom)
"Autophagy and Metabolism in the Hematopoietic System"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Rubinsztein (University of Cambridge, United Kingdom)
"Nutrient Regulation of Autophagy"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Basic Autophagy Mechanisms and Regulation
Discussion Leader: Christian Behrends (Ludwig-Maximilian-University Munich, Germany)
9:00 am - 9:20 am
Sharon Tooze (The Francis Crick Institute, United Kingdom)
"Dynamic Membrane Binding of LC3/GABARAP Regulates Lipidation Reaction Efficiency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Zvulun Elazar (Weizmann Institute of Science, Israel)
"Biogenesis of Non-Selective Autophagosomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Adam Yokom (Berkeley, United States)
"Bridging Membrane, Cargo and Initiation: How ULK1 Does It All"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
Martin Graef (Cornell University, United States)
"Homeostatic Mitophagy Scales Mitochondrial Networks"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Andrea Ballabio (Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"Lysosomal Signaling In Metabolic Adaptation And Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Caroline Kumsta (Sanford Burnham Prebys Medical Discovery Institute, United States)
"Inhibition of Early-acting Autophagy Genes in C. elegans Neurons Extends Lifespan and Improves Proteostasis via ATG-16.2 WD40 Domain"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Mathieu Bourdenx (UK Dementia Research Institute at UCL, United Kingdom)
"Chaperone-Mediated Autophagy: a Gatekeeper of Neuronal Proteostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Patricia Boya (Centro de Investigaciones Biológicas, CSIC, Spain) and Katja Simon (University of Oxford, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular and Structural Mechanisms of Autophagy
Discussion Leader: Mondira Kundu (St. Jude Children's Research Hospital, United States)
7:30 pm - 7:50 pm
James Hurley (University of California, Berkeley, United States)
"Structural Regulatory Mechanisms of Autophagy and Lysosomes"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
Takanori Otomo (San Diego Biomedical Research Institute, United States)
"Structural Insights Into Phagophore Expansion"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Maria Vaccaro (University of Buenos Aires, Argentina)
"Cross-talk Between Ubiquitin and Autophagy in Cancer Stem Cells"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Smriti Parashar (UC San Diego, United States)
"Endoplasmic Reticulum Tubules Limit The Size of Misfolded Protein Condensates"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Selective Autophagy Mechanisms
Discussion Leader: Rushika Perera (University of California, San Francisco, United States)
9:00 am - 9:20 am
Ivan Dikic (Goethe University Frankfurt, Germany)
"Endoplasmic Reticulum Remodelling via ER-Phagy Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Eric Baehrecke (University of Massachusetts Chan Medical School, United States)
"Novel Insights Into the Clearance of Organelles"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Louis Lapierre (Brown University, United States)
"Lipid Droplets Modulate the Selective Autophagy Receptor SQST-1/SQSTM1 Dynamics and Aging"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Paolo Grumati (Fondazione Telethon, Italy)
"ER-Phagy Controls the Transition from Endoplasmic to Sarcoplasmic Reticulum During Myogenesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Francois Le Guerroue (NINDS, United States)
"TNIP1 (Abin1) Negatively Regulates The Rate Of Mitophagy Via Interactions With FIP200 And TAX1BP1"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Benan Mathai (University of Oslo, Norway)
"Regulation of Basal and Stress-Induced Mitophagy in Zebrafish"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Liv Jensen (University of California, Berkeley, United States)
"Membrane Curvature Sensing by the Autophagy Initiation Machinery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autophagy in Disease: Aging and Neurodegenerative Disorders
Discussion Leader: Patricia Boya (Centro de Investigaciones Biológicas, CSIC, Spain)
7:30 pm - 7:50 pm
Susmita Kaushik (Albert Einstein College of Medicine, United States)
"Chaperone-Mediated Autophagy And Lipids: The Fate of Fat in the Hands of Proteins"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ai Yamamoto (Columbia University, United States)
"The Complementary Roles of Autophagy in Neurodegenerative Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ralph Nixon (New York University , United States)
"Autolysosome Acidification Failure In Alzheimer’s Disease: Genetics, Mechanisms, and Broad Pathogenic Consequences"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Ee Phie Tan (The Scripps Research Institute, United States)
"An Autophagy Activator That Improves Fitness and Extends Lifespan in C. elegans"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Degradative Functions of Autophagy Proteins
Discussion Leaders: Katja Simon (University of Oxford, United Kingdom)
9:00 am - 9:20 am
Christian Behrends (Ludwig-Maximilian-University Munich, Germany)
"Exploring the Crosstalk Between Autophagy And Secretion and its Role in Neurodegeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Mondira Kundu (St. Jude Children's Research Hospital, United States)
"Canonical and Non-Canonical Functions of the ULK/Atg1 Family of Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Tara Fischer (NINDS/NIH, United States)
"UnVAILing the Mechanisms of Noncanonical Autophagy Signaling in STING-mediated Innate Immunity "
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Oliver Florey (Babraham Institute, United Kingdom)
"Molecular Features of Non-Canonical Autophagy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Rupert Beale (Francis Crick Institute, United Kingdom)
"Distinct Roles of LC3 Liipidation at Single Membrane Compartments During Influenza and Coronavirus Infection"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Andrew Leidal (University of California, San Francsico, United States)
"Autophagy Cargo Receptors are Secreted Via Extracellular Vesicles and Particles in Response to Endolysosomal Inhibition"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Akhila Rajan (Fred Hutch, United States)
"Atg8 Licenses Adipokine Nuclear Exit"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Autophagy in Cellular Homeostasis
Discussion Leader: Oliver Florey (Babraham Institute, United Kingdom)
7:30 pm - 7:50 pm
Patricia Boya (Centro de Investigaciones Biológicas, CSIC, Spain)
"Age-Dependent Retinal Degeneration In the Context of Autophagy Deficiency"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Nuno Raimundo (Penn State College of Medicine, United States)
"Autophagosome Accumulation Triggers a Signaling Response That Modifies Organelle Homeostasis and Metabolism"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Christina Towers (The Salk Institute for Biological Studies, United States)
"Mitochondrial Homeostasis Maintained in the Absence of Autophagy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Elizabeth Gallagher (University of Pennslyvania, United States)
"The Selective Autophagy Receptor p62 Regulates Lysophagy in HeLa Cells and in Neurons"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Houfu Leng (University of Oxford, United Kingdom)
"Improving Bone Health via Modulation of Glycosphingolipid Metabolism and Autophagy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosome Biology in Autophagy
Discussion Leader: Ralph Nixon (New York University , United States)
9:00 am - 9:20 am
Marja Jaattela (Danish Cancer Society Research Center, Denmark)
"Lysosomes as Regulators of Cellular Ion Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jonathan Goodwin (Casma Therapeutics, United States)
"Control Of MiT/TFE Transcription Factors By FLCN-FNIP Complex Sequestration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Alessia Calcagni (Baylor College of Medicine, United States)
"Batten Disease Protein CLN3 Mediates Lysosomal Tubulation and Autophagic Lysosome Reformation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Roberto Zoncu (University of California, Berkeley, United States)
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Maho Hamasaki (Osaka University, Japan)
"Identification of E3 Ligase Functions In Recognizing Damaged Lysosomes Cleared By Autophagy"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Aurora Scrivo (Albert Einstein College of Medicine, United States)
"Non-Cell Autonomous Regulation of Neuronal Chaperone-Mediated Autophagy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Rukmini Mukherjee (Max Planck Institute of Biophysics/Goethe university, Germany)
"De Novo Regeneration of Lysosomes from Damaged Membranes During Lysophagy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autophagy in Disease: Cancer and Immunity
Discussion Leader: Jayanta Debnath (University of California, San Francisco, United States)
7:30 pm - 7:50 pm
Rushika Perera (University of California, San Francisco, United States)
"Unraveling Autophagy-Mediated Adaptation to Stress in Pancreatic Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kevin Ryan (Cancer Research UK Beatson Institute, United Kingdom)
"Connections Between Autophagy and Programmed Cell Death"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Julie Gavard (INSERM, France)
"Lysosome Vulnerabilities in Brain Tumors"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Andrew Thorburn (Univ. of Colorado Anschutz Medical Campus, United States)
"Targeting Autophagy in Humans and Human Cancers"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure