Gordon Research Conferences - Conference Portfolio (Genetic Toxicology)

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Genetic Toxicology

General Info
Status:	Inactive
Discipline:	Biological
Initial Year:	1981
Cycle:	24 Months

Categories
Environment and Evolution Molecular Cell Biology Pathology

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Conference Description
A decade ago, the study of the impact of DNA damage was seen as a compartmentalised area of cellular research. It is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years it has been increasingly recognised that maintaining genomic stability is crucial to human health and that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms. The Genetic Toxicology Gordon Research Conferences are biannual and the emphasis of the meetings evolves rapidly. Evaluating the nature of genotoxic chemicals lay at the centre of the early conferences. Over the years, the emphasis has moved to understanding how cells and organisms respond to the different forms of genotoxic damage incurred. By understanding these mechanisms, the risk to humans can be more rationally assessed and evaluated. Most recently, the format of the meetings have aimed to facilitate input from the range of disciplines that can provide insight into the field.

Conference Description

A decade ago, the study of the impact of DNA damage was seen as a compartmentalised area of cellular research. It is now appreciated to lie at the centre of an array of cellular responses of crucial importance to human health. Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years it has been increasingly recognised that maintaining genomic stability is crucial to human health and that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The importance of these mechanisms is also underscored by their remarkable conservation between species, allowing the study of simple organisms to provide significant input into our understanding of the underlying mechanisms.

The Genetic Toxicology Gordon Research Conferences are biannual and the emphasis of the meetings evolves rapidly. Evaluating the nature of genotoxic chemicals lay at the centre of the early conferences. Over the years, the emphasis has moved to understanding how cells and organisms respond to the different forms of genotoxic damage incurred. By understanding these mechanisms, the risk to humans can be more rationally assessed and evaluated. Most recently, the format of the meetings have aimed to facilitate input from the range of disciplines that can provide insight into the field.

Meeting History

Year	Meeting Name	Dates	Conference Site	Chair(s)
2011	Genetic Toxicology	Jul 10-15	Renaissance Tuscany Il Ciocco Resort	Jessica A. Downs
2009	Genetic Toxicology	Aug 9-14	Colby-Sawyer College	Samuel H. Wilson
2007	Genetic Toxicology	Jul 29 - Aug 3	Magdalen College	Anthony M. Carr
2005	Genetic Toxicology	Jul 31 - Aug 5	Colby-Sawyer College	Bennett Van Houten
2003	Genetic Toxicology	Aug 10-15	The Queen's College	Penelope Jeggo
2001	Genetic Toxicology	Aug 12-17	Colby-Sawyer College	Thomas A. Kunkel
1999	Genetic Toxicology	Aug 1-6	The Queen's College	Leona D. Samson
1997	Genetic Toxicology	Jun 22-27	Colby-Sawyer College	Kenneth R. Tindall
1995	Genetic Toxicology	Jun 11-16	Colby-Sawyer College	Julian Preston
1993	Genetic Toxicology	Jul 25-30	Colby-Sawyer College	Sid Aaron
1991	Genetic Toxicology	Jun 10-14	Colby-Sawyer College	Richard J. Albertini
1989	Genetic Toxicology	Jun 19-23	Colby-Sawyer College	Daniel A. Casciano
1987	Genetic Toxicology Bioassays	Jun 22-26	Salve Regina University	William G. Thilly
1985	Genetic Toxicology Bioassays, Scientific Basis and Application of	Jun 10-14	Colby-Sawyer College	David F. Krahn
1983	Genetic Toxicology Bioassays, Scientific Basis and Application of	-		Ceinwen A. Schreiner
1981	Genetic Toxicology Bioassays, Scientific Basis and Application of	-		Andrew Sivak

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