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Macromolecular Organization & Cell Function

General Info
Status:	Inactive
Discipline:	Biological
Initial Year:	1987
Cycle:	24 Months

Categories
Developmental Systems Instrumentation Molecular Cell Biology

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Conference Description
Since its inception, the primary theme of the Macromolecular Organization and Cell Function conference has been the essential role of macromolecular assemblies in the organization and function of living cells, as well as the mechanisms that establish and control this organization. These include transient systems, such as multienzyme complexes, which have been historically difficult to study but are of enormous importance in understanding cellular metabolism. A historical area of interest has been applications of new imaging technologies which allow visualization of biological processes in living cells at the molecular level. Other techniques of growing importance and interest, including proteomics, metabolite profiling (metabolomics), and structural biology, which provide for the global analysis of cellular activity and function, are also areas of focus. In this respect, a consistent theme within the meeting has been computational biology and modeling of macromolecular structures and metabolic processes based directly on information obtained by the empirical experimental approaches. Specific sessions at this conference have included discussions of the role of chromatin structure in controlling gene expression, the structuring of water within cells, metabolic control theory, mechanisms of force generation within cells, the evidence for channeling in dynamic and stable multi-enzyme complexes, a reassessment of mitochondrial structure and function, and the use of noninvasive methods such as NMR, fluorescence spectroscopy, molecular imaging and one of the first applications of optical tweezers to study intact living cells and organisms. Conferees are also exposed to historical perspectives, on topics such as how our concepts of cell structure and the intracellular milieu have evolved over the years, particularly during the 5 minute introduction given by the Discussion Leaders to begin each session. Recently the Paul Srere Memorial lecture, named after the conference co-founder, also has served this purpose.

Conference Description

Since its inception, the primary theme of the Macromolecular Organization and Cell Function conference has been the essential role of macromolecular assemblies in the organization and function of living cells, as well as the mechanisms that establish and control this organization. These include transient systems, such as multienzyme complexes, which have been historically difficult to study but are of enormous importance in understanding cellular metabolism. A historical area of interest has been applications of new imaging technologies which allow visualization of biological processes in living cells at the molecular level. Other techniques of growing importance and interest, including proteomics, metabolite profiling (metabolomics), and structural biology, which provide for the global analysis of cellular activity and function, are also areas of focus. In this respect, a consistent theme within the meeting has been computational biology and modeling of macromolecular structures and metabolic processes based directly on information obtained by the empirical experimental approaches. Specific sessions at this conference have included discussions of the role of chromatin structure in controlling gene expression, the structuring of water within cells, metabolic control theory, mechanisms of force generation within cells, the evidence for channeling in dynamic and stable multi-enzyme complexes, a reassessment of mitochondrial structure and function, and the use of noninvasive methods such as NMR, fluorescence spectroscopy, molecular imaging and one of the first applications of optical tweezers to study intact living cells and organisms. Conferees are also exposed to historical perspectives, on topics such as how our concepts of cell structure and the intracellular milieu have evolved over the years, particularly during the 5 minute introduction given by the Discussion Leaders to begin each session. Recently the Paul Srere Memorial lecture, named after the conference co-founder, also has served this purpose.

Meeting History

Year	Meeting Name	Dates	Conference Site	Chair(s)
2008	Macromolecular Organization & Cell Function Cellular Systems Biology	Jul 27 - Aug 1	Magdalen College	Robert S. Balaban Loranne Agius
2006	Macromolecular Organization & Cell Function	Aug 6-11	Mount Holyoke College	Ronald M. Lynch Stephen Oliver
2004	Macromolecular Organization & Cell Function	Aug 15-20	The Queen's College	Christopher D. Hardin Judit Ovadi
2002	Macromolecular Organization & Cell Function	Aug 4-9	The Queen's College	Brenda Winkel Kevin M. Brindle
2000	Macromolecular Organization & Cell Function	Aug 6-11	The Queen's College	Natalie S. Cohen Hans V. Westerhoff
1998	Macromolecular Organization & Cell Function	Sep 13-18	The Queen's College	John E. Wilson Douglas B. Kell
1996	Macromolecular Organization & Cell Function	Sep 1-6	The Queen's College	James S. Clegg
1995	Enzyme Organization & Cell Function	Jan 15-20	Casa Sirena Hotel	Murray Deutscher
1993	Enzyme Organization & Cell Function	Jan 18-22	Casa Sirena Hotel	Harvey Knull
1991	Enzyme Organization & Cell Function	Jan 21-25	Casa Sirena Hotel	Christopher Mathews
1989	Organization of Metabolic Sequences	Jan 30 - Feb 3	Ventura Beach Marriott	G. Rickey Welch
1987	Organization of Metabolic Sequences	Jan 19-23	Miramar Hotel	Paul A. Srere

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