The following list contains every Conference in the GRC Portfolio. Click on any title to view more detailed information for that
particular Conference. The conference list can be sorted by name, discipline, initial year, or status by clicking on the
appropriate column heading. The list can also be narrowed down in different ways by selecting one of the tabs below.
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Select Category:
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Protein Processing, Trafficking & Secretion
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General Info
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Status:
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Active
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Discipline:
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Biological
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Initial Year:
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1994
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Cycle:
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24 Months
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Conference Description
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This conference series, initiated in 1994 by Drs. Michel Chrétien and Donald Steiner, was originally called “Hormonal and Neural Peptide Biosynthesis”. It has since grown into a major international forum for the discussion of new research developments related to the post-translational processing, trafficking and secretion of bioactive peptides and other secretory pathway proteins, as well as the significance of these processes to human disease and cellular physiology. These include protein folding events in the endoplasmic reticulum; all post-translational processing steps including structural, biochemical and cellular analyses of endo- and exoproteolysis and N- and C-terminal modifications; intra-Golgi and post-Golgi sorting events; mechanisms of vesicle formation and trafficking; and molecular mechanisms of regulated and constitutive secretion. Studies on the implications of defective processing for physiology and disease, as well as the development of animal models and silencing techniques for various protein/enzyme targets are some of the main attractions of this meeting. An additional important focus is on emerging functions of processing enzymes, including intramembrane proteolysis, and the associated pathologies whose underlying basis relates to protein processing and/or cellular trafficking. Thus, the meeting addresses core translational biology issues of importance to various pathologies and to the development of novel therapeutics. These include childhood diseases, neuroendocrine disorders such as diabetes, and neurodegenerative diseases such as Alzheimer's disease, dyslipidemias such as hypercholesterolemia and atherosclerosis, chronic pain, hypertension, viral glycoprotein and microbial maturation, cancer/metastasis, and many others.
A Gordon Research Seminar (GRS) is held in conjunction with this Conference. Click here for more information about the associated GRS.
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