Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Enzymology of Natural Products
Discussion Leader: Bo Li (University of North Carolina at Chapel Hill, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Vinayak Agarwal (Georgia Institute of Technology, United States)
"Proteusin Peptides: Unknown Structures and Unknown Binding Modes for RiPP Biosynthesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Vahe Bandarian (University of Utah, United States)
"Leveraging Radical Enzymology towards Synthesis of Novel Scaffolds"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Sarah O'Connor (Max Planck Institute for Chemical Ecology, Germany)
"Enzymatic Reactions in Natural Product Pathways"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemistry at the Membrane
Discussion Leader: Marco Bellinzoni (Institut Pasteur, France)
9:00 am - 9:30 am
Ming Zhou (Baylor College of Medicine, United States)
"Mechanism of Diiron Center Reduction in Stearoyl-CoA Desaturase-1"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Russell DeBose-Boyd (University of Texas Southwestern Medical Center, United States)
"Proteostatic Control of Cholesterol Homeostasis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Group Photo / Coffee Break
10:35 am - 11:05 am
Anirban Banerjee (National Institutes of Health, United States)
"Orthogonal Enzyme–Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
Bharath Srinivasan (AstraZeneca PLC, United Kingdom)
"Automated High Throughput Analysis of Non-Equilibrium Inhibition in Kinase Inhibitor Discovery: Case Study of ErbB Receptor Family Members"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Katherine Hicks (State University of New York at Cortland, United States) and Andrew Gulick (University at Buffalo, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycobiology
Discussion Leader: Karen Allen (Boston University, United States)
7:30 pm - 8:00 pm
Tania Lupoli (New York University, United States)
"Chemoenzymatic Routes to Activated Rare Sugar Substrates of Bacterial Glycosyltransferases"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Rich Olson (Wesleyan University, United States)
"Enlisting an Endogenous Glycosidase to Study V. Cholerae Biofilm Assembly and Dispersal"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Barbara Imperiali (MIT, United States)
"Microbial Glycan Biology Making Sense of the Madness: Or at Least Trying to!"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cofactors and Metals
Discussion Leader: Wen Zhu (Florida State University, United States)
9:00 am - 9:30 am
Hening Lin (Howard Hughes Medical Institute / Cornell University, United States)
"The Enzymology and Physiological Function of N-Terminal Glycine Myristoyltransferase"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
Oscar Juarez (Illinois Institute of Technology, United States)
"The Electron Transfer and Ion Pumping Mechanisms of the Evolutionary Divergent NQR Family"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
Andrea Mattevi (University of Pavia, Italy)
"The Enzymology of a Metabolon"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
Anne-Frances Miller (University of Kentucky, United States)
"Electron Transfer Bifurcation: Versatile Energy Conservation in Apparent Defiance of the Second Law of Thermodynamics"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Visualizing Biochemical Processes
Discussion Leader: Dali Liu (Loyola University Chicago, United States)
7:30 pm - 8:00 pm
Markos Koutmos (University of Michigan, United States)
"Unlocking Macromolecular Dynamics with Cofactors and Small Molecules"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Songon "Song" An (University of Maryland, Baltimore County (UMBC), United States)
"Real-Time Visualization of Glucose Metabolism through Multienzyme Glucosome Assemblies in Living Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Abraham Beyene (Janelia Research Campus, United States)
"An Optical Assay for Spatiotemporally Resolved Imaging of Dopamine Release from Single Boutons"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzymology and Protein Engineering
Discussion Leader: Audrey Lamb (University of Texas at San Antonio, United States)
9:00 am - 9:30 am
Wenjun Zhang (University of California Berkeley, United States)
"Biosynthesis of Clickable Functionalities in Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Huimin Zhao (University of Illinois at Urbana-Champaign, United States)
"New Tools and Strategies for Protein Engineering"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Graham Moran (Loyola University Chicago, United States)
"Two Oddly Complex Dehydrogenases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Areas in Enzymology
Discussion Leader: Randy Kipp (Relay Therapeutics, United States)
7:30 pm - 8:00 pm
Celia Schiffer (University of Massachusetts Chan Medical School, United States)
"Pre-Emptively Avoiding Drug Resistance: Lessons from Viral Proteases: From HIV to SARS-CoV-2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Lana Saleh (New England Biolabs, United States)
"Biochemical Insight into 5-Methylpyrimidine Oxidation and Its Regulation in Bacteriophages"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Alanna Schepartz (University of California, Berkeley, United States)
"Recent Efforts to Hijack Molecular Machines for Chemistry, Biology, and Medicine"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Nucleotide Enzymology and Biotechnology
Discussion Leader: Rahul Banerjee (Auburn University, United States)
9:00 am - 9:30 am
Kathy Fange Liu (The University of Pennsylvania, United States)
"Sex Chromosome-Encoded Homologous Enzymes in Sex Bias of Translation Regulation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Kristin Koutmou (University of Michigan, United States)
"mRNA Pseudouridylation by PUS7 Enhances Cellular Stress Tolerance"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Jeremiah Hanes (Ansa Biotechnologies, United States)
"Accelerating Synthetic Biology: Breakthroughs in Enzymatic DNA Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Biological Chemistry and its Applications
Discussion Leader: Bruce Palfey (University of Michigan, United States)
7:30 pm - 8:15 pm
Dan Herschlag (Stanford University, United States)
"MLAFrom Structure–Function to Ensemble–Function: A New Paradigm for Quantitative Understanding of Protein Function"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Dorothee Kern (Brandeis University/HHMI, United States)
"Aiming Higher: In Energy and Functional Understanding of Enzymes"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure