Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Endolysosomal Function in the Nervous System
Discussion Leader: Lois Weisman (University of Michigan, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Sandra Maday (Perelman School of Medicine, University of Pennsylvania, United States)
"Lysosomal Pathways in Synaptic Signaling Between Neurons and Astrocytes"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Pietro De Camilli (Yale University, United States)
"Bridge-like Lipid Transport Proteins in the Endo-Lysosomal System"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Mark von Zastrow (University of California, San Francisco, United States)
"Role of the Endocytic Pathway in Sculpting GPCR Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Stéphane Vassilopoulos (Sorbonne University, France)
"The Actin-Spectrin Submembrane Scaffold Restricts Endocytosis Along Proximal Axons"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding Lysosomal Physiology and Disease
Discussion Leader: Gillian Griffiths (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Shawn Ferguson (Yale University School of Medicine, United States)
"Lysosome Adaptations That Confer Parkinson's Disease Risk"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Patricia Kane (Upstate Medical University, State University of New York, United States)
"Reversible Disassembly of V-ATPases in Aging and Neurodegenerative Disease"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Sarah Jinn (Merck Research Laboratories, United States)
"Genetics to therapeutics: modulation of TMEM175 as Parkinson’s Disease therapeutics to enhance lysosomal function"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Anastasia Henry (Denali Therapeutics, United States)
"LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Monther Abu-Remaileh (Stanford University, United States)
"Intra-Lysosomal Lipid Metabolism: Builders, Degraders and Regulators"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Tobias Walther (Sloan Kettering Institute, United States)
"Mechanisms of Lysosomal Degradation of Sphingolipids"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ming Li (University of Michigan, United States)
"A Peroxisome-Derived Lipid and its Regulation of Lysosomal Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hijai Regina Shin (UT Southwestern, United States)
"Lysosomal GPCR-Like Protein in Nutrient Sensing and Cellular Growth Control"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ming-Yuan Su (Southern University of Science and Technology, China)
"Structural Biology of Amino Acid Sensing Mechanisms in mTORC1 Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Mara Duncan (University of Michigan, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Trafficking and Regulation
Discussion Leader: Elizabeth Conibear (University of British Columbia, Canada)
7:30 pm - 7:50 pm
Joost Holthuis (Osnabrück University, Germany)
"Transbilayer Lipid Dynamics and Signalling in Lysosomal Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Amra Saric (The Hospital for Sick Children, Canada)
"ER-Localized Sorting Nexins Support Lipid Droplet Growth at ER-Endolysosome-Lipid Droplet Contacts"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Christopher Burd (Yale School of Medicine, United States)
"Inter-Organelle Lipid Trafficking"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Julie Brill (The Hospital for Sick Children, Canada)
"Mutual Dependence of Osbp and PI4KII in the Maturation of Regulated Secretory Granules"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Emma Jones (University of Bristol, United Kingdom)
"Global Identification of Integral Membrane Proteins that Require Retromer for Their Sorting in Neuronal Systems"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Navigating Cellular Barriers: Pathogens, Phagosomes, and Beyond
Discussion Leader: Max Gutierrez (The Francis Crick Institute, United Kingdom)
9:00 am - 9:20 am
Rebecca Lamason (Massachusetts Institute of Technology, United States)
"Microbial Manipulation of Host Membranes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nihal Altan-Bonnet (National Institutes of Health, United States)
"Enhanced Viral Transmission through Autophagosomal and Lysosomal en bloc Egress"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maria João Amorim (Católica Biomedical Research Centre - Universidade Católica Portuguesa, Portugal)
"The Host Endocytic Recycling Pathway is Impaired During Influenza A Virus Infection to Form Liquid Organelles"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Arun Radhakrishnan (University of Texas Southwestern Medical Center, United States)
"Role of Membrane Cholesterol Accessibility in Host-Pathogen Interactions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jason King (University of Sheffield, United Kingdom)
"The Regulation of Phagosomal Maturation by PIKfyve/PI(3,5)P2 "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Laure David (Digestive Health Research Institute, France)
"Mechanisms of Autophagic-Lysosomal Dysfunction Induced by Bacterial Extracellular Membrane Vesicles"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Melanie Ohi (University of Michigan, United States)
"From Blobs to Atoms and Back to Blobs: Using Cryo-EM to Understand the Structure of Caveolin"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Lysosome, Autophagy, and Cellular Catabolism
Discussion Leader: James Hurley (UC Berkeley, United States)
7:30 pm - 7:40 pm
Petia Adarska (Freie Universität Berlin, Germany)
"Multi-Functional ARF1 Compartments Mediate Secretory and Endocytic Trafficking by Maturing into Recycling Endosomes"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Derrick Gibbings (University of Ottawa, Canada)
"mRNA Translation in Proximity to Forming Autophagosomes Promotes Sustained Autophagy"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Christopher Shoemaker (Geisel School of Medicine at Dartmouth, United States)
"Endolysosomal Trafficking of BNIP3 Couples Lipid Peroxidation and Mitophagy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Matthew Broadus (Casma Therapeutics, United States)
"Targeting the Fip200 Initiation Complex to Direct Selective Autophagy and Activate Bulk Autophagy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Oliver Florey (Babraham Institute, United Kingdom)
"The Role of Non-Canonical Autophagy as a Lysosome Stress Response"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jingyue Cassano (University of New Mexico, United States)
"Lysosomal Damage Induces Stress Granule Formation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Claudio Bussi (Nanyang Technological University, Singapore)
"Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endolysosomal Function and Dysfunction in Neurodegeneration
Discussion Leader: Gilbert Di Paolo (Denali Therapeutics, United States)
9:00 am - 9:20 am
Haoxing Xu (Liangzhu Laboratory and Zhejiang University , China)
"Proton Release Mechanisms in the Lysosome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Aimee Kao (University of California, San Francisco, United States)
"Lysosomal Proteases and pH Regulation in Neurodegenerative Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Martin Kampmann (University of California, San Francisco, United States)
"Elucidating Endolysosomal Mechanisms in Neurodegeneration Using Unbiased CRISPR Screens"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Fenghua Hu (Cornell University, United States)
"Physiological and Pathological Functions of TMEM106B, a Lysosomal Membrane Protein Associated With Neurodegeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Edoardo Marcora (Icahn School of Medicine at Mount Sinai, United States)
"Human Genetics Implicates Efferocytosis in Myeloid Cells as a Disease Risk Hub for Alzheimer's Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Neuza Domingues (MIA-Portugal, Multidisciplinary Institute of Ageing, University of Coimbra, Portugal)
"Dysfunctional Lysosomes in Batten Disease Impact the Lipid Composition of the Nuclear Envelope and Activate Apoptotic Signaling Pathways"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Shyamal Mosalaganti (University of Michigan, Ann Arbor, United States)
"In Situ Snapshots of Protein Aggregate Turnover"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technologies and Therapeutic Opportunities
Discussion Leader: Sandra Schmid (Chan Zuckerberg Biohub, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Tom Kirchhausen (Harvard Medical School, United States)
"Constitutive Endolysosomal Perforation in Neurons"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Emeline Bonsergent (Max Planck Institute, Germany)
"Isolation of Endosomal Subpopulations to Characterize Endosomal Escape During RNA Delivery"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Aditya Anand (Genentech, Inc., United States)
"Endolysosomal Escape During Exogenous Antigen Presentation by Dendritic Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Arthur de Jong (Scenic Biotech B.V., The Netherlands)
"Discovery of a Novel Niemann Pick type C (NPC) Disease Modifier and Development Towards its Clinical Application"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Lauren Bird (University of Melbourne, Australia)
"Subversion of Host Lysosomal Proteolysis by Coxiella Burnetii"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Layla Nassar (Yale University, United States)
"JIP4 Controls Cystinosin Stability at Lysosomes"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Endocytosis and Mechanisms of Intracellular Trafficking
Discussion Leaders: Michael Marks (Children's Hospital of Philadelphia, United States) and Christophe Lamaze (Institut Curie, France)
9:00 am - 9:20 am
Judith Klumperman (University Medical Center Utrecht, The Netherlands)
"The HOPS Complex: Integrating Lysosomal Trafficking Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rytis Prekeris (University of Colorado, United States)
"The Role of Rab40-Dependent Ubiquitylation in Regulating Endocytic Recycling and Activation of Rap GTPases During Cell Migration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Costin Antonescu (Toronto Metropolitan University, Canada)
"Regulation of Distinct Phases of EGFR Signaling by Tetraspanin and Clathrin Nanodomains at the Cell Surface"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Yuuta Imoto (St. Jude Children's Research Hospital, United States)
"Orchestrated Synaptic Nano-Architectures for Efficient Synaptic Vesicle Endocytosis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Aurelien Roux (University of Geneva, Switzerland)
"In Vitro Dynamics of Membrane Remodelling by Archeal ESCRT-III"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Anne Spang (Biozentrum, University of Basel, Switzerland)
"Coordination Between ESCRT Function and Rab Conversion During Endosome Maturation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Cedric Delevoye (INEM, INSERM, France)
"Cytoskeleton-Driven Spatialization of a Lysosome-Like Organelle Contributes to Genome Protection"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
David Murray (University of Dundee, United Kingdom)
"Cell Processes and the Programming of Trafficking"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Protein-Lipid Interactions in Regulation of Cellular Membrane Dynamics
Discussion Leader: Scott Emr (Cornell University, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
Harald Stenmark (Oslo University Hospital, Norway)
"Converging Mechanisms of Lysosome Repair"
8:50 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure