Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Iron-Sulfur Cofactors
Discussion Leader: Alexandra Brown (Princeton University, United States)
3:45 pm - 4:15 pm
Daniel Suess (Massachusetts Institute of Technology, United States)
"Chemical Modification of Iron-Sulfur Cofactors"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural and Mechanistic Insights into the Reactivity of Metalloenzymes
Discussion Leader: Katherine Buettner (Gettysburg College, United States)
7:30 pm - 7:45 pm
Chi-Yun Lin (The Pennsylvania State University, United States)
"A Unique Redox-Active Network Supports Catalysis in Francisella Ribonucleotide Reductase"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Chang Liu (UC Berkeley, United States)
"Bioinformatic Discovery of a Cambialistic Monooxygenase"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Elise Rivett (Michigan State University, United States)
"Deciphering the Catalytic Mechanism(s) of Nitrous Oxide Production: A New Model for Position-Specific Kinetic Isotope Effects"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Jesse Taylor (The Pennsylvania State University, United States)
"Characterization of an Unusual Metalloenzyme Containing a [FeFe] Hydrogenase and Rubrerythrin Domains"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Naike Ye (Massachusetts Institute of Technology, United States)
"Molecular Basis of Nitrile Formation in Eagle Toxin Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Synthetic Models of Nature's Catalysts
Discussion Leader: Jonathan Kuo (The Pennsylvania State University, United States)
9:00 am - 9:15 am
Jessica Kim (MIT, United States)
"Electronic Simplification of Fe–S and Mo–Fe–S Clusters to Probe Metal–Metal Interactions"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Nabhendu Pal (University of Minnesota Twin Cities, United States)
"An S = 1 Nonheme FeIV=O Complex more Powerful than the Highly Reactive S = 2 FeIV(O)TQA Complex: How Critical is the Spin State?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Suman Patra (Indian Association for the Cultivation of Science, Kolkata, India)
"Outer-Coordination Sphere Interaction in a Molecular Iron Catalyst Allows Selective Methane Production from Carbon Monoxide and Carbon Dioxide"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Sophie Webb (University of Geneva, Switzerland)
"Understanding Enzyme-Nanoparticle Interactions During Electroenzymatic Hydrogen Formation"
10:30 am - 10:40 am
Discussion
10:40 am - 10:55 am
Liam Grunwald (ETH Zürich, Switzerland)
"Structural, Electronic, Magnetic and Electrochemical Considerations on Canonical Iron-Sulfur Cubanes"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Spectroscopy as a Window into the Electronic Structure and Function of Metallocofactors
Discussion Leader: Hannah Shafaat (University of California, Los Angeles, United States)
1:30 pm - 1:45 pm
Evan Burke (Penn State University, United States)
"Mechanistic Insight into the Unique Radical-Polar Crossover Mechanism of Ethylene-Forming Enzyme (EFE) Using Stopped-Flow Fourier-Transform Infrared Spectroscopy"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Olesya Ablyasova (Helmholtz-Zentrum Berlin für Materialien und Energie, Germany)
"Electronic State of a Dioxidomanganese(V) and Bis(mu-oxo) Di-Manganese Oxide Cluster Revealed by XAS and XMCD"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Jieun Shin (Yale University, United States)
"Tuning the Reactivity/Substrate Selectivity of the Mn4CaO5 Cluster in Photosystem II to Perform Non-Natural Photocatalysis"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes