Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Current Perspectives on Drug Addiction
Discussion Leader: Asaf Keller (University of Maryland School of Medicine, United States)
7:40 pm - 8:05 pm
Amy Newman (National Institute on Drug Abuse Intramural Research Program, NIH, United States)
"Dopamine D3 Receptor-Directed Medication Development for the Treatment of Substance Use Disorders: Where We Are, Where We’re Going"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Yavin Shaham (Intramural Research Program, National Institute on Drug Addictions, NIH, United States)
"Animal Models of Relapse After Voluntary Abstinence: Behavior, Circuits, and Implications for Treatment"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Marina Wolf (Oregon Health & Science University, United States)
"Incubation of Cocaine Craving: A Homeostatic Plasticity Hypothesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Progress in Neuropeptide Research
Discussion Leader: Sabita Roy (University of Miami, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Bryan Roth (UNC Chapel Hill Medical School, United States)
"Unpublished Research on Psychedelics"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Hamed Ekhtiari (Department of Psychiatry, University of Minnesota, United States)
"Targeting Addiction Neurocircuits with Transcranial Brain Stimulation: From Engagement to Precision"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Mickael Degoulet (Aix-Marseille University, France)
"The Subthalamic Nucleus is a Critical Hub to Predict and Manipulate Compulsive-Like Cocaine Seeking"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Marsida Kallupi (UCSD, United States)
"Identification of Individual Differences in Response to Methadone, Buprenorphine, and Naltrexone in Animal Models of Opioid Use Disorder"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Lorenzo Leggio (National Institutes of Health, United States)
"Mind the Gut: Translational Approaches to Develop New Pharmacotherapies for Addiction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Hedy Kober (Yale University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Addiction Treatment: Novel Developments
Discussion Leader: Lucía Hipólito (University of Valencia, Spain)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Stephanie Borgland (University of Calgary, Canada)
"Effects of Co-Released Orexin and Dynorphin on Ventral Tegmental Area Dopamine Neuronal Activity and Opioid Seeking"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Anushree Karkhanis (Binghamton University - SUNY, United States)
"Adolescent Adversity Mediated Maladaptive Changes in Opioid Neurobiology in Striatopallidal Areas"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Michael Bruchas (University of Washington, United States)
"Dynamic Opioid Release Gates Action-Outcome Behaviors and Reward Seeking"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Brain Circuit Mechanisms of Drug Addiction
Discussion Leader: Yan Dong (University of Pittsburgh, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Mary Kay Lobo (University of Maryland School of Medicine, United States)
"Ventral Basal Ganglia Cell Type Transcriptomes in Addiction Models"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Paul Kenny (Icahn School of Medicine at Mount Sinai, United States)
"Cellular Mechanisms of Opioid Reward and Aversion"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Jeremy Day (University of Alabama at Birmingham, United States)
"Defining an Ensemble: Molecular Mechanisms Linking Drug-Induced Physiological and Transcriptional Dynamics to Reinforcement"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Eric Augier (Linköping University, Sweden)
"From Alcohol to Opioids and Stimulants: A Role of the GABA Transporter GAT-3 in SUDs"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Jean-Lud Cadet (Molecular Neuropsychiatry Research Branch, NIDA, United States)
"Mimicking Methamphetamine Use Disorder in Rodents: Epigenetic and Transcriptional Consequences in Brain Reward Circuits"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular and Molecular Mechanisms of Drug Addiction
Discussion Leader: Jacqueline McGinty (Medical Univ SC, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Lori Knackstedt (University of Florida, United States)
"Using Translational Rodent Models of Polysubstance Use to Identify Novel Circuitry Underlying Drug Seeking"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Mark Andermann (Beth Israel Deaconess Medical Center, United States)
"Insular Cortex Contribution to Nicotine Addiction"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Karine Guillem (CNRS UMR 5287, France)
"Dysfunctions of the Ventromedial Prefrontal and Associated Attentional Deficits in Nicotine Addiction"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vulnerability Factors in Drug Addiction
Discussion Leader: Gavan McNally (University of New South Wales, Australia)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Karen Ersche (University of Cambridge, United Kingdom)
"Understanding Aberrant Learning and Decision-Making in Human Cocaine Addiction"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Stephanie Groman (Groman Lab, United States)
"Decision-Making Mechanisms Underlying Addiction Susceptibility"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
David Belin (University of Cambridge, United Kingdom)
"The Paths to Compulsion: New Insights into the Role of Negative Reinforcement in the Development of Addiction"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Caitlin Orsini (The University of Texas at Austin, United States)
"The Relationship Between Chronic Opioid Use and Changes in Risk Taking"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Leandro Vendruscolo (National Institute on Drug Abuse, United States)
"The Stress of Opioid Addiction: Neurobiological Systems Controlling Opioid-Related Behaviors"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reinforcement and Decision-Making Mechanisms in Drug Addiction
Discussion Leader: Megan Fox (Penn State College of Medicine, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Abraham Palmer (University of California San Diego, United States)
"Studying Intermediate Phenotypes to Elucidate the Genetic Basis of Substance Use Disorders"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Philippe Faure (CNRS, France)
"Nicotine, Dopamine, and Individuality: The Interplay of Factors"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Joseph Cheer (University of Maryland School of Medicine, United States)
"A Transcriptomic Program Controls Cue-Related Dopaminergic Vulnerability to Opioid Seeking Following Prenatal THC Exposure"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Animal Models: Novel Developments and Applications
Discussion Leader: Amy Janes (NIDA, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Leonie Koban (CNRS, France)
"An fMRI Neuromarker of Drug and Food Craving"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Rita Goldstein (Icahn School of Medicine at Mount Sinai, United States)
"Markers of Neural Recovery in Human Drug Addiction: What Does Language Have to Do with It?"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Ryan Bogdan (Washington University in St. Louis, United States)
"Neural Correlates of Substance Involvement: Cause and/or Consequence?"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Rainer Spanagel (CIMH, Germany)
"Molecular and Brain-Network Signatures of Cocaine Addiction: Data from Cocaine Addicted Rats and Humans"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Brenda Curtis (NIDA-IRP, United States)
"Digital Phenotypes of People Who Use Drugs"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroimaging-Based Markers of Drug Addiction
Discussion Leader: Nicholas Gilpin (LSU Health Sciences Center New Orleans, United States)
7:30 pm - 7:55 pm
Michael Taffe (University of California, San Diego, United States)
"The Self-Administration of Drugs by Vapor Inhalation in a Rat Model"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Anne-Noel Samaha (University of Montreal, Canada)
"Relapse After Intermittent Cocaine Use: Effects of Cues Signaling Drug Delivery Versus Cues Signaling Drug Availability"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Brandon Henderson (Joan C Edwards School of Medicine at Marshall University, United States)
"The Role of Flavors, Diet and Other Substances on the Reinforcement of Nicotine"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure