Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Structure, Activity and Regulation
Discussion Leader: Blessing Ogboo (University at Buffalo, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Sigrid Noreng (Genentech, United States)
"Structure of the Core Human Phagocyte NADPH Oxidase NOX2"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Marta Massari (University of Pavia, Italy)
"Building a Platform for Enzymatic and Biophysical Characterization of NOXs"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
How Oxidants Cross-Talk
Discussion Leaders: Maleka Stewart (St. John's University, United States) and Yongzhong Wu (NIH, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Xena Marie Williams (West Virginia University School of Medicine, United States)
"Indirect Antioxidant Effects of the Nitrite Anion: Focus on Xanthine Oxidase"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Shambhu Yadav (Brigham and Women’s Hospital, Cardiovascular Division, Harvard Medical School, United States)
"Selective Sensory Ataxia Caused by Chemogenetic Oxidative Stress"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mosi Lin (St. John's University, United States)
"Mechanisms of a7 Nicotinic Acetylcholine Receptor Agonists in Supplemental Oxygen-Induced Inflammatory Lung Injury and Pulmonary Infection"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Rut Espinosa-Sotelo (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"Role of the NADPH Oxidase NOX4 in the Liver Tumor Microenvironment"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Opportunity NOX, NADPH Oxidases as Novel Therapeutic Targets
Discussion Leader: Marta Massari (University of Pavia, Italy)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Mariana de Oliveira (University of Campinas, Brazil)
"Pharmacological Inhibition of NAPDH Oxidase NOX2 Improves Bladder Dysfunction in Murine Cyclophosphamide-Induced Cystitis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yongzhong Wu (NIH, United States)
"Exogenous DNA Upregulates DUOX2 Expression and Function in Human Pancreatic Cancer Cells by Activating the cGAS-STING Signaling Pathway"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Irene Peñuelas-Haro (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Spain)
"The NADPH Oxidase NOX4 Inhibits c-Myc and Nrf2 Activation and Protects Cells from Oxidative Stress in Hepatocellular Carcinoma"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Victor Thannickal (Tulane University School of Medicine, United States)
"Targeting NOX Enzymes in Pulmonary Fibrosis"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Driving Your Research Career Forward
Discussion Leader: Carmen Veith (CureVac AG, Germany)
1:30 pm - 2:30 pm
Panel Discussion
Career Panel
Victor Thannickal (Tulane University School of Medicine, United States)
Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
Albert Van Der Vliet (University of Vermont, United States)
Louise Hecker (Emory University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes