Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Groundbreaking Discoveries in Organellar Channels and Transporters
Discussion Leader: Bruno Gasnier (Université Paris Cité, France)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Yuriy Kirichok (Washington University in St. Louis, United States)
"Mechanisms of Mitochondrial H+ Leak"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Barbara Ann Halkier (University of Copenhagen, Denmark)
"Identification of Specialized Metabolite Exporter Assigns a New Role to Transporter Family"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Douglas Wallace (Co-Organizer/Speaker, United States)
"A Heart Felt Tale of Two ANTS"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Dynamic Mitochondrion and Chloroplasts
Discussion Leader: Shey-Shing Sheu (Thomas Jefferson University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Dipayan Chaudhuri (University of Utah, United States)
"The Mitochondrial Calcium Uniporter Compensates for Complex I Dysfunction"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ildiko Szabo (University of Padova, Italy, Italy)
"Mitochondrial Potassium Channel-Linked Signaling Events Profoundly Alter Cancer Cell Behavior"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Eric Taylor (The University of Iowa, United States)
"The Liver Mitochondrial Dicarboxylate Carrier Regulates Whole-body Glucose Homeostasis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ute Armbruster (University of Düsseldorf, Germany)
"Synchronization of Photosynthetic Reactions by Thylakoid Ion Transport"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Markus Schwarzlander (University of Muenster, Germany)
"Management and Function of Mitochondrial Ca2+ Uptake in Plants"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Franz Hagn (Technical University of Munich, Germany)
"Structural Basis of Metabolite Transport by the Chloroplast Outer Envelope Channel OEP21"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Bogusz Kulawiak (Instytut Biologii Doswiadczalnej, Poland)
"The Relationship between the Mitochondrial BKCa Channel and the Cellular Redox State"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Shubha Gururaja Rao (Ohio Northern University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Mitochondrion and Chloroplasts
Discussion Leader: Markus Rapedius (Nanion Technologies, Germany)
6:00 pm - 6:20 pm
Erin Connolly (Pennsylvania State University, United States)
"Cellular Iron Compartmentalization Mechanisms in Plants"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Grace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, United States)
"Mitochondrial Dysfunction Mediated by ER-Calcium Dysregulation in Alzheimer’s Disease"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Isabella Grumbach (University of Iowa, United States)
"Ca2+ Exchange at the ER-Mitochondrial Interface and its Effect on Cell Proliferation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Piotr Bednarczyk (Warsaw University of Life Sciences - SGGW, Poland)
"The Role of the Mitochondrial Potassium Channels in Damage Caused by Urban Particulate Matters"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Katrin Philippar (Saarland University, Germany)
"Plant FAX Proteins - The Flow of Fatty Acids from Chloroplasts to ER (and Beyond?)"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Master Regulator of Membrane Trafficking and Cellular Calcium: Endoplasmic Reticulum and Golgi Apparatus
Discussion Leader: Evgeny Pavlov (New York University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Montserrat Samso (Virginia Commonwealth University, United States)
"Structure and Dynamics of the Ryanodine Receptor"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Klaus Groschner (Medical University of Graz, Austria)
"A New Look at Ca2+ Handling Within ER-PM Signaling Units"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Mariia Zeziulia (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany)
"Proton-Gated Anion Transport Governs Macropinosome Shrinkage"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Gyorgy Hajnoczky (Thomas Jefferson University, United States)
"IP3 Receptor-Mediated Calcium Signaling in Health and Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Edgar Peiter (Martin Luther University Halle-Wittenberg, Germany)
"Transport and Homeostasis of Calcium and Manganese in Compartments of the Plant Secretory Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Quentin Lejeune (Université Catholique de Louvain, Belgium)
"Structure-Function Analysis of the Yeast Golgi-Localized Ca2+-Mn2+/H+ Gdt1p Transporter"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Shouguang Huang (University of Wuerzburg, Germany)
"A Light-Gated ChannelRhodopsin Powers Proton-Induced Calcium Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Endoplasmic Reticulum and Golgi Apparatus
Discussion Leader: Amalia Dolga (Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands)
6:00 pm - 6:20 pm
Mohamed Trebak (University of Pittsburgh, United States)
"Non Canonical Functions of STIM Proteins in Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Qiu-Xing Jiang (Laoshan Laboratory / Hauptman-Woodward Med. Res. Inst./SUNY-Buffalo / UF, China)
"Irreversible Processes for Exquisite Temperature Sensitivity of TRP Channels"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Rainer Hedrich (Wuerzburg University, Germany)
"Optogenetics Provide New Insight into the Molecular Mechanism of Ca2+ Signaling in Stomatal Guard Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Viktor Belay (Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, United States)
"Structural Dynamics of Adenine Nucleotide Potentiation of Human IP3 Receptor Type 2"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Rajini Rao (Johns Hopkins University, United States)
"The Golgi Calcium ATPase in Health and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Concepts: Vesicle and Vacuoles
Discussion Leader: Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Zhaozhu Qiu (Johns Hopkins University, United States)
"Discovery of a New Proton-Activated Chloride (PAC) Channel and Its Surprising Role in Endosomes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Yi-Fang Tsay (Institute of Molecular Biology, Academia Sinica, Taiwan)
"Study of Vacuole Glycerate Transporter NPF8.4 Reveals a New Role of Photorespiration in N Flux"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Teresa Alonso (IBGM, Valladolid, Spain, Spain)
"Direct Measurements of Luminal Ca2+ with Endo-Lysosomal GFP-Aequorin (ELGA) Reveal Functional IP3 Receptors"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Karin Schumacher (Heidelberg University, Germany)
"The V-ATPase - a Proton Pump for Vesicles and Vacuoles"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Bruno André (Université Libre de Bruxelles (ULB), Belgium)
"Membrane Transporters of the Yeast Vacuole"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Rob Roelfsema (University of Wuerzburg, Germany)
"Role of the Vacuole on Ca2+ Homeostasis and Generation of Ca2+ Signals in Plant Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Melody Cools (Labiris, Belgium)
"Lysine Trafficking and Compartmentalization in the Yeast Vacuole"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Vesicle and Vacuoles
Discussion Leader: Michael Zhu (University of Texas Health Science Center at Houston, United States)
6:00 pm - 6:20 pm
Haoxing Xu (Liangzhu laboratory & Zhejiang University Medical Center, China)
"Proton Release Mechanisms in the Lysosome"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Lynette Nel (Aarhus University, Denmark)
"Sterol Homeostasis in Vacuoles of Saccharomyces Cerevisiae Mediated by Niemann-Pick Type C Related Protein 1"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Christian Grimm (Ludwig Maximilian University of Munich, Germany)
"TRPML3: An Endolysosomal Cation Channel in Lung Emphysema and COPD"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Rajan Sah (Washington University in St. Louis, United States)
"Lysosomal LRRC8 Complex Regulates Nutrient-Stimulated mTOR Signaling"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Marc Freichel (Institute of Pharmacology, University Heidelberg, Germany)
"Organellar Ca2+ Regulators (OCaRs) determining NAADP-Mediated Ca2+ Release from Acidic Intracellular Stores in Pancreatic Acinar Cells and Cardiomyocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Nuclear Ion Channels
Discussion Leader: Yamuna Krishnan (University of Chicago, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Michele Mazzanti (University of Milano, Italy, Italy)
"Chloride Intracellular Channel 1 as a Privilege Receptor Mediating Metformin Antiproliferative Action on Glioblastoma Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Vera Moiseenkova-Bell (University of Pennsylvania, United States)
"Structural and Functional Studies of TRPML1 in Situ"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Shridhar Sanghvi (The Ohio State University, United States)
"An Exosomal Large Conductance Calcium-Activated Potassium Channel Regulates its Cargo and Function"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Youxing Jiang (University of Texas Southwestern Medical Center, United States)
"Lysosomal pH Regulation by LAMP-1 and LAMP-2"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Mario Delmar (New York University School of Medicine, United States)
"The Nuclear Envelope Architecture in Arrhythmogenic Cardiomyopathy"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Evgeny Onishchenko (University of Bergen, Norway)
"Pulse-Labelling Mass Spectrometry Reveals Age-Dependent Compositional Plasticity of the Yeast Nuclear Pore Complex"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Arezu Jahani-Asl (University of Ottawa, Canada)
"OSMR Interactome Mapping Reveals the Significance of a Chloride Channel in Cytokine Regulation and Glioblastoma Progression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intracellular Ion Channel Physiology and Novel Techniques
Discussion Leader: Damian Bell (Sophion Bioscience, Denmark)
6:00 pm - 6:20 pm
Pinaki Talukdar (Indian Institute of Science Education and Research Pune, India)
"Development of Artificial Ion Channels to Target Cancer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Paul DeCaen (Northwestern University, Feinberg School of Medicine, United States)
"Primary Cilia Ion Channels as Regulators of Hippocampal Excitability"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Antonio Felipe (Universitat de Barcelona, Spain)
"The Mitochondrial Kv1.3 Channel"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
SOUMAVA PALIT (IIT BOMBAY, India)
"Structural Analysis and Aggregation of Proteins in Solution and Poration of Endosomal Membranes by a Comparative Study using Dissipative Particle Dynamics and Molecular Dynamics"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Menachem Moshelion (The Hebrew University of Jerusalem, Israel)
"Stress is Basic: The Role of Vascular Bundle Sheath Cells' V-H+ ATPase and P-H+ ATPase Pumps in Regulating Leaf Hydraulics via Blue Light and ABA Opposing Signals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure