SUNDAY |
2:00 PM | Arrival and Registration |
6:00 PM | Dinner |
7:45 - 9:30 PM | Tyrosyl/Thiyl Radicals in Ribonucleotide Reductase |
| Discussion Leader: A. Graslund (Stockholm U.) |
7:45 PM | J. Stubbe (MIT)
"Radical chain initiation in ribonucleotide reductases" |
8:35 PM | B.M. Sjoberg (Karolinska)
"The evolution of ribonucleotide reductases revisited" |
MONDAY |
9:00 AM - 12:30 PM | Radicals in Catalysis |
| Discussion Leader: M. Bollinger (Penn State U.) |
9:00 AM | D. Logan (Lund U.)
"Metal binding and allosteric regulation in class III ribonucleotide reductases" |
9:45 AM | D. Dooley (Montana State University)
"Cofactor formation in galactose oxidase" |
10:30 AM | COFFEE |
11:00 AM | W. Van der Donk (U. of Illinois)
"Identification of radical intermediates in prostaglandin synthase" |
11:45 AM | N. Lewis (Washington State)
"Plant phenol coupling protein factors: dirigent proteins and dirigent sites" |
7:30 - 9:45 PM | Radicals/ Fe/S Biogenesis |
| Discussion Leader: J. Broderick (Michigan State) |
7:30 PM | M. Marletta (UCB)
"Pterin radical formation during nitric oxide synthase turnover" |
8:15 PM | D. Dean (Virginia Tech)
"Role of molecular scaffolds in Fe-S cluster biosynthesis" |
9:00 PM | R. Lill (U. of Marburg)
"Iron-sulfur protein biogenesis in eukaryotes: an essential role of mitochondria" |
TUESDAY |
9:00 AM - 12:30 PM | Quinones: Catalysis |
| Discussion Leader: F. S. Mathews (Washington U.) |
9:00 AM | M. McPherson (Leeds)
"Structure, function and mechanisms of amine oxidases" |
9:45 AM | P. Siegbahn (Uppsala)
"Quantum chemical studies of ribonucleotide reductase and amine
oxidase" |
10:30 AM | COFFEE |
11:00 AM | H. Gray (CalTech)
"Probing protein derived cofactors with electron tunneling wires" |
11:45 PM | K. Tanizawa (Osaka)
"A novel quinone cofactor, cysteine tryptophylquinone, encaged by multiple thioether crosslinks, in bacterial quinochemoprotein
amine dehydrogenases" |
7:30 - 9:45 PM | Quinones: Catalysis and Signaling |
| Discussion Leader: J. Stubbe (MIT) |
7:30 PM | V. Davidson (U. of Miss.)
"Probing the mechanisms of action and biosynthesis of tryptophan tryptophylquinone enzymes by site-directed mutagenesis" |
8:15 PM | S. Jalkanen (U. of Turku)
"A cell surface amine oxidase directly controls leukocyte trafficking" |
9:00 PM | S. Rhee (NIH)
"Intracellular messenger function of H2O2 and its regulation by peroxiredoxin" |
WEDNESDAY |
9:00 AM - 12:30 PM | PS II and Cytochrome Oxidase: A Tribute to Jerry Babcock |
| Discussion Leader: S. Ferguson-Miller (Michigan State U.) |
9:00 AM | D. Britt (U.C. Davis)
"The tyrosine-manganese complex of photosystem II, recent advances from EPR spectroscopy" |
9:45 AM | T. Kitagawa (Okazaki)
"Visible- and UV-Resonance Raman Characterization of the P intermediate of Bovine Cytochrome c Oxidase" |
10:30 AM | COFFEE |
11:00 AM | P. Brzezinski (Stockholm)
"Intermediate states during oxygen reduction by cytochrome c oxidase" |
11:45 AM | H. Michel (Frankfurt)
"Timing and mechanism of proton pumping by cytochrome c oxidase" |
7:30 - 9:45 PM | Non-Redox, Protein-Derived Cofactors |
| Discussion Leader: P. Knowles (U. of Leeds) |
7:30 PM | R. Tsien (UC San Diego)
"Fluorescent protein chromophores and synthetic replacements" |
8:15 PM | S. J. Remington (U. of Oregon)
"Investigation of cellular redox potentials and pH with ratiometric GFP
biosensors" |
9:00 PM | J. Retey (Karlsruhe)
"4-Methylidene-imidazol-2-one (MIO), an electrophilic prosthetic group and its function in the catalysis by histidine and phenylalanine ammonia lyases" |
THURSDAY |
9:00 AM - 12:30 PM | Sulfur-Containing Cofactors |
| Discussion Leader: S. Booker (Penn State U.) |
9:00 AM | A. Claiborne (Wake Forrest)
"Parameters for cysteine-sulfenic acid function in catalysis and regulation" |
9:45 AM | J. Jarrett (U. of Pennsylvania)
"Biotin synthase: a single -turnover self-destructing enzyme" |
10:30 AM | COFFEE |
11:00 AM | M. Fontecave (U. Joseph Fournier)
"Visiting biotin synthase again and again: more secrets disclosed" |
11:45 AM | T. Begley (Cornell)
"Mechanistic and structural studies on thiamin biosynthesis in bacteria" |
7:45 - 9:30 PM | B-12 and SAM as Radical Generators |
| Discussion Leader: M. Marletta (UCB) |
7:45 PM | R. Banerjee (U. of Nebraska)
"Vitamin mediated radical rearrangements" |
8:35 PM | P. Frey (U. of Wisc-Madison)
"The 5'-deoxyadenosyl radical in radical SAM and B12 reactions" |