SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Addresses |
| Dr. John Savill, Center for Inflammation Research, University of Edinburgh The importance of being eaten |
| Dr. Michael Hentgartner, University of Zurich Corpse disposal in C. elegans |
9:30 pm - 10:00 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Surface changes leading to recognition of apoptotic cells |
| Discussion Leader: Patrick Williamson, Amherst |
| David Daleke, Indiana University Molecular Control of Transmembrane Phosphatidylserine Distribution |
| Donna Bratton, National Jewish Medical and Research Center Regulation of membrane phospholipid scrambling in cellular activation and apoptosis |
| Yoshinobu Nakanishi, Kanazawa University Molecular link between clearance of apoptotic cells and innate immunity:a role for toll-like receptor 4 in phagosome/lysosome fusion in macrophages |
| Andrew Devitt, The University of Edinburgh
Requirements for engulfment of human apoptotic leukocytes by macrophages |
| Joseph Witztum, University California San Diego A role for phospholipid oxidation in uptake of apoptotic cells |
| Giovanna Chimini, INSERM-CNRS, Marseilles ABC transporters and membrane dynamics during engulfment of apoptotic cells |
12:30 pm | Group Photo / Lunch |
4:00 pm - 6:00 pm | Posters: (last names beginning A through K) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Surface changes leading to recognition of apoptotic cells II |
| Discussion Leader: Robert Schlegel, Pennsylvania State University |
| Valerian Kagan, University of Pittsburgh Appetizing rancidity of apoptotic cells for macrophages: oxidative signaling by phosphatidylserine |
| Bengt Fadeel, Karolinska Institut Programmed cell clearance: studies on the mechanism and importance of phosphatidylserine exposure and plasma membrane blebbing during fas-trigger apoptosis |
| Alan Schroit, MD Anderson, Houston, Texas Bridging proteins and lipid-directed phagocytosis |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Phagocytosis of dying cells: receptors and mechanics |
| Discussion Leader: John Savill, Center for Inflammation Research, University of Edinburgh |
| Peter Henson, National Jewish Medical and Research Center The role of collectins and CD91 in apoptotic cell engulfment |
| Akiko Shiratsuchi, Kanazawa University Expression pattern and function of SR-BI, a phosphatidylserine-binding phagocytosis receptor of testicular Sertoli cells |
| Christopher Gregory, University Edinburgh The role of CD14 in apoptotic-cell clearance by macrophages: in vitro and in vivo studies |
| Ray Birge, UMONJ-New Jersey Medical School A role for integrins in phagocytosis of of apoptotic cells |
| Kodi Ravichandran, University of Virginia Signalling to engulfment: the different courses of a good meal! |
| Robert Sclegel, Pennsylvania State University Dual role for phosphatidylserine on phagocyte and apoptotic cell target |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Posters: (last names beginning L through Z) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Apoptotic cell clearance and implications for autoimmunity |
| Discussion Leader: Dror Mevorach, Hadassah Hospital and the Hebrew University |
| Marco Radic, University of Tennessee Apoptotic cells as targets for autoreactive B cells |
| Keith Elkon, University of Washington The role of
natural antibodies in the opsonization of dead and dying cells |
| Marina Botto, Imperial College School of Medicine London Systemic lupus erythematosus: a disease of impaired disposal of apoptotic cells? |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clearance of apoptotic cells: invertebrates rule! |
| Discussion Leader: Ding Xue, University of Colorado, Boulder |
| Nathalie Franc, University College London Phagocytosis of apoptotic cells in Drosophila: Croquemort and beyond |
| Kristin White, MGH, Harvard Genetic analysis of apoptotic corpse clearance in Drosophila |
| Yi-chun Wu, University ofTaiwan Receptors that initiate clearance of apoptotic cells in C. elegans |
| Xiao-chen Wang, University of Colorado, Boulder New players that regulate cell corpse recognition and engulfment in C. elegans |
| Irene Tatischeff, Universite Paris Dictiostelium as a new model for studying clearance of apoptotic cells |
12:30 pm | Lunch |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Apoptotic cells and immunity |
| Discussion Leader: Valerie Fadok, National Jewish Medical and Research Center |
| Lynda Stuart, Centre for Inflammation Research, University of Edinburgh Effects of apoptotic cell uptake on dendritic cell maturation; lessons from the mouse |
| Thomas Ferguson, Washington University School Of Medicine Apoptotic cells and induction of tolerance in the immune system |
| Dror Mevorach, Hadassah University The immune response to apoptotic cells: mechanisms of tolerance and autoimmunity |
| Douglas Green, La Jolla Institute For Allergy And Immunology fFifteen minutes in the life and death of a cell |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Apoptotic cell clearance and inflammatory disease |
| Discussion Leader: Valerie Fadok |
| R. William Vandivier, University Of Colorado Health Sciences Center, Denver, Co Implications for defective apoptotic cell clearance in the pathogenesis of chronic airway inflammatory disease |
| Ian Dransfield, Centre for Inflammation Research, University of Edinburgh Strategies for
augmenting phagocyte clearance of apoptotic cells in inflammation |
| Yoshiro Kobayashi, Toho University Regulatory mechanisms of
macrophage response following phagocytosis of apoptotic cells |
| David Ucker, University of Illinois College of Medicine Mechanism of modulation of phagocyte inflammatory responses exerted by the corpse |
| Jen Monks, National Jewish Medical and Research Center, Denver Apoptotic cell clearance during mammary gland involution |
| Luciana Dini, University of Lecce Does T electromagnetic pollution influence clearance of apoptotic cells? |
12:30 pm | Lunch |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Consequences of apoptotic cell clearance |
| Discussion Leader: Peter Henson, National Jewish Medical and Research Center |
| Lars Holmgren, Cancer Center Karolinska Institute Horizontal gene transfer following engulfment of apoptotic cells |
| Zsuzsa Szondy, University of Debrecen Tissue transglutaminase is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity |
| Elizabeth Vernon-Wilson, Center for Inflammation Research, Edinburgh Macrophage discrimination of apoptotic cells: A novel role for CD31 |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |