SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:40 pm | Introductory Comments by Chairs: Martin Herrmann and Yoshinobu Nakanishi |
7:40 pm - 9:10 pm | The Beginnings: The Mechanisms and Consequences of Apoptotic Cell Clearance (Keynote Presentations) |
| Discussion Leader: Robert Schlegel (Pennsylvania State University) |
7:40 pm - 8:15 pm | John Savill (University of Edinburgh)
"The meaning of apoptotic cell phagocytosis" |
8:15 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Courtney Frasch (National Jewish Medical and Research Center)
"The mechanism of apoptotic cell phagocytosis" |
9:00 pm - 9:10 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Recognition: The Way Phagocytes Find Their Targets |
| Discussion Leader: David Ucker (University of Illinois) |
9:00 am - 9:25 am | Pat Williamson (Amherst College)
"The guts of the machine: Insights into the mechanism of lipid transport" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ding Xue (University of Colorado)
"PS externalization and cell corpse recognition in C. elegans" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:45 am | Coffee Break / Group Photo |
10:45 am - 11:10 am | Shige Nagata (Kyoto University, Japan)
"Tim4 as a phosphatidylserine receptor" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | In-San Kim (Kyungpook National University, Korea)
"Stabilin-2 as a phosphatidylserine receptor" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Kodi Ravichandran (University of Virginia)
"BAI1 as a phosphatidylserine receptor" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Response: Maintenance of Tissue Homeostasis through Removal of Dying Cells |
| Discussion Leader: Angelo Manfredi (DIBIT Milano, Italy) |
7:30 pm - 7:50 pm | Stefan Nierkens (La Jolla Institute for Allergy and Immunology)
"Cross-presentation of apoptotic cell antigens" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Patrizia Rovere-Querini (DIBIT Milano, Italy)
"Innate response to cell death: tissue remodeling and stem cell recruitment" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Kerstin Sarter (University of Erlangen-Nürnberg, Germany)
"Galectins as ligands for late apoptotic cells" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Udo S. Gaipl (University of Erlangen-Nürnberg, Germany)
"Annexins as immune modulators" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Masato Tanaka (RIKEN, Japan)
"Mechanism of tolerance induction to cell-associated antigens by apoptotic cell clearance" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Players: Newly Identified Molecules Working at the Onset of Clearance |
| Discussion Leader: Yoshiro Kobayashi (Toho University, Japan) |
9:00 am - 9:25 am | Nathalie Franc (University College London)
"Undertaker/Retinophilin, a Drosophila Junctophilin links Draper and drCed-6 to calcium homeostasis during phagocytosis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Zheng Zhou (Baylor College of Medicine)
"Phagocytic receptor CED-1 initiates a phagosome maturation pathway" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Lukas Neukomm (University of Zurich, Switzerland)
"Negative regulators of engulfment in C. elegans" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Marc Freeman (University of Massachusetts)
"Shark, a Draper adaptor" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Estee Kurant (Rockefeller University)
"Searching for Simu partners in phagocytosis" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Takayuki Kuraishi (Kanazawa University, Japan)
"Pretaporter, a Draper ligand" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Failure: Diseases Developed from Inefficient Removal of Apoptotic Cells |
| Discussion Leader: Chris Gregory (University of Edinburgh) |
7:30 pm - 7:55 pm | Reinhard E. Voll (University of Erlangen-Nürnberg, Germany)
"Failure of apoptotic cell clearance in patients with SLE" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alexander Gabibov (Russian Academy of Science)
"Catalytic anti-dsDNA autoantibodies in the clearance of apoptotic remnants" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Johan van der Vlag (Nijmegen, Netherlands)
"Apoptotic blebs and apoptosis-modified chromatin: killers of tolerance" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Kristin Fenton (University of Tromsö, Norway)
"Anti-nuclear immune response" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Alternatives: The Meaning of Apoptotic Cell Clearance in Physiologic State |
| Discussion Leader: Nathalie Franc (University College London) |
9:00 am - 9:25 am | Mike Overholtzer (Sloan-Kettering Cancer Center)
"Eaten alive: Modeling entosis in human cancers" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Nick Baker (Albert Einstein College of Medicine)
"The active role of corpse engulfment pathways during cell competition" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Silvia Finnemann (Cornell University)
"Diurnal engulfment of photoreceptor cell fragments in the retina" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Eric Baehrecke (University of Massachusetts)
"Genetic regulation of cell clearance during autophagic cell death" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Jason Mercer (ETH Zurich, Switzerland)
"Apoptosis mimicry: virus infection by PS-mediated macropinocytosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | The Consequences: The Meaning of Apoptotic Cell Clearance in Sub-Physiologic State |
| Discussion Leader: Adam Lacy-Hulbert (MIT) |
7:30 pm - 7:55 pm | Adam Lacy-Hulbert (MIT)
"Kiss and tell: contact with apoptotic cells and macrophages" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Chris Gregory (University of Edinburgh)
"Apoptosis and macrophages: the cancer connection" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Sandra Franz (University of Edinburgh)
"Phagocyte recognition of 'decorated' dead cells" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Effects: Positive and Negative Regulation of Apoptotic Cell Clearance |
| Discussion Leader: Kirsten Lauber (University of Tuebingen, Germany) |
9:00 am - 9:25 am | Xiaojing Ma (Cornell University)
"Transcription factors activated during phagocytosis of apoptotic cells that regulate cytokine production" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Kirsten Lauber (University of Tuebingen, Germany)
"Role of MFG-E8 in glucocorticoid-mediated enhancement of apoptotic cell removal" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Dennis Discher (University of Pennsylvania)
"CD47 inhibition of phagocytosis: species specificity, variants, and cytoskeleton" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Jerry Levine (University of Illinois)
"Signaling events in phagocytes taking up dead cells" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Luis E. Munoz (University of Erlangen-Nürnberg, Germany)
"Inflammation by misrouted secondarily necrotic remnants" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected Poster (TBA) |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 4 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Use: Clinical Application of Apoptotic Cell Clearance |
| Discussion Leader: Sandra Franz (University of Edinburgh) |
7:30 pm - 7:55 pm | Selected Poster (TBA) |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Adrian E. Morelli (University of Pittsburgh)
In situ-targeting of dendritic cells with apoptotic cells restrains the anti-donor response and ameliorates signs of acute and chronic rejection in cardiac allografts in mice" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Thomas Schwarz (University-Clinic Schleswig-Holstein, Germany)
"Mode of action in photopheresis: update on the role of regulatory T cells" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |