SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
5:00 pm | Welcome Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Opening |
| Discussion Leader: David Klein (National Institutes of Health) |
7:30 pm - 8:10 pm | Keynote address: Tony Hunter (The Salk Institute)
"Signaling by protein phosphorylation in the age of genomics" |
8:10 pm - 8:50 pm | Keynote address: John Scott (HHMI/Vollum Institute)
"The Molecular Architecture of Signaling Complexes" |
8:50 pm - 9:30 pm | Alastair Aitken (University of Edinburgh, UK)
"A historical perspective on 14-3-3: a date to remember?" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structure and ligand recognition |
| Discussion Leader: Andrey Shaw (Washington University) |
9:00 am - 9:20 am | Andrey Shaw (Washington University)
"14-3-3 recognition Motifs" |
9:20 am - 10:00 am | Fred Dyda (NIH)
"A molecular scaffold: conformational modulation
by the 14-3-3 proteins" |
10:00 am - 10:30 am | Conference photo & Coffee Break |
10:30 am - 11:10 am | Claudia Oecking (Universitat Tubingen, Germany)
"A fungal toxin and its action on a 14-3-3 regulatory complex" |
11:10 am - 11:50 am | Michael Yaffe (Massachusetts Institute of Technology)
"Proteomic approaches to protein kinase signaling pathways mediated by phosphoserine/threonine-binding domains" |
11:50 am - 12:30 pm | Deborah Morrison (NIH)
"Role of 14-3-3 proteins in Ras signaling" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mitogenic and oncogenic signal transduction |
| Discussion Leader: Deborah Morrison (NIH) |
7:30 pm - 8:10 pm | Satoshi Inoue (University of Tokyo, Japan)
"The role of 14-3-3sigma proteolysis in breast cancer growth" |
8:10 pm - 8:50 pm | Kun-Liang Guan (University of Michigan)
"Function of the TSC2 tumor suppressor protein
in cell growth and cell size" |
8:50 pm - 9:30 pm | Guri Tzivion (Texas A&M University)
"14-3-3 proteins as potential proto-oncogenes: insights from a 14-3-3 transgenic mouse model" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell cycle control and survival signaling |
| Discussion Leader: Yukiko Gotoh (University of Tokyo, Japan) |
9:00 am - 9:45 am | Keynote address: Helen Piwnica-Worms (HHMI/Washington University)
"14-3-3 proteins in cell cycle- and checkpoint-control" |
9:45 am - 10:25 am | Azad Bonni (Harvard Medical School)
"Cdc2 regulation of BAD-14-3-3 interaction in neuronal apoptosis" |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:30 am | Erinn H. Goldman (Emory University)
"Prosurvival function of 14-3-3 proteins" |
11:30 am - 12:10 pm | Angel Lopez (Hanson Center for Cancer Research, Australia)
"14-3-3 integrates phosphoserine and phosphotyrosine signals to
promote cell survival and proliferation" |
12:10 pm - 12:30 pm | Yukiko Gotoh (University of Tokyo, Japan)
"JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetics and development |
| Discussion Leader: Elizabeth Yang |
7:30 pm - 8:10 pm | Paul van Heusden (Leiden University, The Netherlands)
"Genetic analysis of 14-3-3 function in the yeast
Saccharomyces cerevisiae" |
8:10 pm - 8:50 pm | Anthony Muslin (Washington University)
"Differential function of 14-3-3 isoforms in vertebrate development" |
8:50 pm - 9:30 pm | Anthony Wynshaw-Boris (University of California-San Diego)
"The role of 14-3-3epsilon in mammalian brain development" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolic regulation I |
| Discussion leader: Alison Hickman (NIH) |
9:00 am - 9:40 am | David Klein (NIH)
"Role of 14-3-3 protein in biological time keeping" |
9:40 am - 10:20 am | Tohru Ichimura (Tokyo Metropolitan University, Japan)
"Metabolic control by 14-3-3 proteins" |
10:20 am | Coffee Break |
10:50 am - 11:30 am | Min Li (Johns Hopkins University)
"Receptor forward trafficking: a role of 14-3-3?" |
11:30 am - 12:10 pm | Carol MacKintosh (University of Dundee, UK)
"14-3-3s as integrators of cellular metabolism and survival in plant
and human cells" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hot topics I: Novel functions and regulation |
| Discussion Leader: Alastair Aitken (University of Edinburgh, UK) |
| Topic: Novel function and mechanism of regulation |
| Maria Zannis-Hadjopoulos (McGill University, Canada)
"Mammalian 14-3-3 proteins and their S. cerevisiae homologues are binding to cruciform DNA and associate with origins of DNA Replication" |
| Nam-On Ku (Stanford University)
"Keratins as modulators of 14-3-3 proteins and vice versa" |
| Aziz Ghahar (University of Alberta, Canada)
"14-3-3 functions as a potent collagenase stimulating factor" |
| Topic: Role of dimerization and phosphorylation |
| Jo M Woodcock (Hanson Center for Cancer Research, Australia)
"Regulation of 14-3-3 dimerisation and function by lipid-activated kinases" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolic regulation II |
| Discussion leader: Bert de Boer (Vrije University, The Netherlands) |
9:00 am - 9:40 am | Steve C. Huber (University of Illinois)
"Divalent cations and the binding of 14-3-3s to nitrate reductase" |
9:40 am - 10:20 am | Jan Szopa (University of Wroclaw, Poland)
"14-3-3 gene expression level affects potato metabolism" |
10:20 am | Coffee Break |
10:50 am - 11:30 am | Robert Ferl (University of Florida)
"Localization and target affinities - 14-3-3 interaction specificities
in Arabidopsis" |
11:30 am - 11:50 am | Michael Roberts (Lancaster University, UK)
"Pollen 14-3-3 proteins are required for fertilisation in tobacco" |
11:50 am - 12:30 pm | Bert de Boer (Vrije University, The Netherlands)
"14-3-3 function in plant embryonic root growth and Xenopus embryo
development" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hot topics II - Therapeutic implications |
| Discussion Leader: Bengt Hallberg (Umea University, Sweden) |
| Topic: Vascular inflammation |
| Wang Min (Yale University)
"14-3-3 in shear stress and vascular inflammation" |
| Topic: Neurodegenerative disorders |
| Rene Anand (Louisiana State University)
"14-3-3 proteins regulate the biogenesis of nicotinic receptors deficient in Alzheimer's Disease: therapeutic implications" |
| Helen Baxter (University of Edinburgh, UK)
"14-3-3 as a diagnostic marker for CJD" |
| Topic: Cancer |
| Mong-Hong Lee (UT MD Anderson Cancer Center)
"Regualtion of p53 by 14-3-3 in breast cancer" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |