SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ATP and oxygen consumption of the working brain |
| Discussion leader: Albert Gjedde
(Pathophysiology and Experimental Tomography Center, Aarhus University Hospitals, Center of Functionally Integrative Neuroscience, DK) |
| Rolf Gruetter (Department of Radiology and Neuroscience University of Minnesota Center for MR Research, Minneapolis, MN)
Energy metabolism of neurons and glia in vivo: The enigma of lactate, glycogen and uncoupling |
| Fahmeed Hyder (Magnetic Resonance Research Center,Yale University School of Medicine, New Haven, CT)
Oxygen consumption in relation to localized brain activity in vivo |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Astrocytes in neurometabolic coupling |
| Discussion leader: Leif Hertz (Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada) |
| Maiken Nedergaard (Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, USA) Glia-to-glia, and glia-to-neuron signaling |
| Coffee Break / Group Photo |
| Ursula Sonnewald (Department of Clinical Neurosciences, Norwegian Institue for Science and Technology, Trondheim, Norway)
Glial-neuronal interaction in neurotransmitter synthesis |
| Marianne Fillenz (University Laboratory of Physiology, Oxford, UK)
Glutamate released from astrocytes as the source of lactate |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session ("Metabolism", "MR", "Ischemia") |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Energetic costs of neuro-transmission |
| Discussion leader: Pierre Magistretti (Institut de Physiologie, Universite de Lausanne, Lausanne, Switzerland) |
| Douglas Rothmann (Magnetic Resonance Research Center, Departments of Diagnostic Radiology, Biomedical Engineering, and Molecular Biophysics and Biochemistry, and Section of Bioimaging Sciences, Yale University School of Medicine, New Haven, USA) Energetic costs of neurotransmitter turn-over |
| Luc Pellerin (Institut de Physiologie, Universite de Lausanne, Lausanne, Switzerland)
Neuron-glia interaction in the regulation of brain glucose utilization |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neurovascular coupling I |
| Discussion leader: Wolfgang Kuschinsky
(Department of Physiology, University of Heidelberg, Germany) |
| Edith Hamel (Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC, Canada) Innervation of brain microvessels in the integration of local vasomotor responses |
| Robert V. Harrison (Auditory Science Laboratory, Department of Otolaryngology and Brain and Behaviour Division, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada)
Blood capillary distribution correlates with hemodynamic-based functional imaging in cerebral cortex |
| Steven Segal (The John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT , USA)
Cell-to-cell conduction in microvascular networks during blood flow control |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session ("Metabolism", "MR", "Ischemia") |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neurovascular coupling II |
| Discussion leader: Ulrich Dirnagl
(Department of Experimental Neurology, Humboldt University Berlin) |
| Timothy McMahon (Duke University Medical Center, Durham, NC, USA)
Vascular regulation and nitric oxide/oxygen delivery by hemoglobin |
| David R. Harder (Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA)
Astrocytes function in matching blood flow to metabolic activity |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neural underpinnings of BOLD and vascular signals used in functional neuroimaging |
| Discussion leader: Robert Turner (Wellcome Dept Imag Neurosci, FIL, London, UK) |
| Marcus Raichle (Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St. Louis, USA)
Searching for a baseline: functional imaging and the resting human brain
|
| Nikos Logothetis (Max Planck Institute for Biological Cybernetics, Tübingen, Germany)
Neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal.
|
| Martin Lauritzen (Department of Clinical Neurophysiology, Glostrup Hospital and University of Copenhagen, Glostrup, Denmark)
Relationship of spikes, synaptic activity, and local changes of cerebral blood flow
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session ("Blood Flow and Oxygenation") |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methodological frontiers |
| Discussion leader: Bruce Rosen
(Department of Radiology, Massachusetts General Hospital, Boston, Mass. USA) |
| David Kleinfeld (Dept. of Physics, University of California, La Jolla, USA)
Imaging and perturbing blood flow in cortical microvessels with ultrashort pulsed laser light: Insights from a new rodent model for flow in normal and diseased vasculature |
| Alan P. Koretsky (Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda , USA)
Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging
|
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clinical aspects of neurovascular coupling |
| Discussion leader: Costantino Iadecola
(Division of Neurobiology, Weill Medical College, Cornell University, New York, USA) |
| Stanley Rapoport (NIH Natl Inst Aging, Bethesda, USA)
Quantifying brain phospholipid metabolism involving fatty acids in vivo: Energy consumption, neurotransmitter-initiated signaling and modulation by lithium and diet
|
| David Eidelberg (North Shore University Hospital, New York University School of Medicine, Manhasset, New York, USA)
Functional brain imaging of movement disorders
|
| Arno Villringer (Department of Neurology, Humboldt Universtity, Berlin, Germany)
Vascular response during inhibition, synchronized brain activity and disturbed neurovascular coupling |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session ("Blood Flow and Oxygenation") |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hot topics: Last minute breakthroughs and selected presentations from posters |
| Discussion leader: Kamil Ugurbil (Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis , USA) |
| Keynote lecture: Rodolfo Llinas (Department of Physiology, New York University School of Medicine, New York, NY, USA)
Consciousness and the electrophysiology of mammalian neurons and circuits |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |