SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Introduction to Integrins and the SIBLING Family |
7:30 pm - 7:40 pm | Discussion Leader: William T. Butler (Univ. Texas-Houston) Welcome |
7:40 pm - 8:20 pm | Dwayne Stupack (University of California, San Diego)
"Integrins: Signal Transduction and Other Functions" |
8:35 pm - 9:15 pm | Tyra Wolfsberg (NHGRI/NIH, Bethesda, Maryland)
"Genetic Relationship of SIBLING genes" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Shared Functions of SIBLINGs |
| Discussion Leader: Adele Boskey (Hospital for Special Surgery, New York) |
9:00 am - 9:25 am | Harvey Goldberg (University of Western Ontario, Canada)
"SIBLINGs in Matrix Mineralization" |
9:35 am - 10:00 am | Vincent Castronovo (University of Liege, Belgium)
"SIBLING Expression in Cancer" |
10:00 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Neal Fedarko (Johns Hopkins University, Baltimore, MD)
"MMP Activation by SIBLINGs" |
11:15 am - 11:40 am | Kalu Ogbureke (Medical College of Georgia)
"SIBLING & MMP Co-localization in Soft Tissues" |
11:50 am - 12:30 pm | Short Poster Talks I |
| Laila Huq "Conformational and genetic similarities within proteins involved in biomineralisation and calcium phosphate stabilization encoded on human chromosome 4" |
| Gregory Johnson "Osteopontin Contributes to Conceptus Attachment and Decidual Angiogenesis" |
| Luc Malaval " BSP -/- mice display lower turnover, higher bone mass and slower bone repair, and lose bone after tail suspension or ovariectomy" |
| Lauren Pachman "Characterization of Pathological Calcification in active Juvenile Dermatomyositis (JDM) Following Invasion of Soft Tissues by Sandworms (Ancylostoma Braizilense)" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Osteopontin & Mineral Metabolism |
| Discussion Leader: Esben Sorensen (University of Aarhus, Denmark) |
7:30 pm - 7:50 pm | Cecilia Giachelli (University of Washington, Seattle)
"OPN: Roles in Vascular Calcification & Disease" |
8:00 pm - 8:20 pm | Masaki Noda (Tokyo Medical & Dental University)
"OPN Function in Bone Biology" |
8:30 pm - 8:50 pm | Keith Hruska (Washington University School of Medicine, St. Louis, MO)
"OPN Function in Osteoclasts" |
9:00 pm - 9:30 pm | Short Poster Talks II |
| Goran Andersson "Distinct phosphorylation sites regulate adhesion and migration of macrophages on human milk osteopontin" |
| Christian Kazanecki "Differences in Post-Translational Modifications of Murine OPN" |
| Keiko Suzuki "Immunocytochemical Analysis of Osteopontin Function in Osteoclast Formation and Activation" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | OPN in Cancer, Inflammation & Immunity |
| Discussion Leader: Susan Rittling (Rutgers University) |
9:00 am - 9:20 am | David Denhardt (Rutgers University)
"Osteopontin Signaling" |
9:30 am - 9:50 am | Ann Chambers (University of Western Ontario, Canada)
"The Role of OPN in Cancer" |
10:00 am - 10:30 am | Coffee break |
10:30 am - 10:50 am | Toshimitsu Uede (Hokkaido University, Japan)
"OPN in Tissue Remodeling & Fibrosis" |
11:00 am - 11:20 am | Mari Shinohara (Harvard Medical School)
"Osteopontin Expression in Dendritic Cells Regulates Type I Immunity" |
11:30 am - 12:30 pm | Short Poster Talks III |
| Hongbin Cao "Relationship between Osteopontin Expression and Radiation Resistance in Head and Neck Squamous Cell Carcinomas" |
| Hongyan Diao (presented by Shigeyki Kon) "Osteopontin as a Mediator of NKT Cell Function in T Cell-mediated Liver Diseases" |
| Yu-Hua Hsieh "Tumor Promotion is Delayed in Osteopontin Null Mice" |
| Lotte Schack "Osteopontin in milk - implications in neonate immunity?" |
| Andre Paes Da Silva "Role of Osteopontin in Inflammatory Colitis" |
| Johannes Weiss "Recombinant Eukaryotic Osteopontin (OPN) Induces Dendritic Cell Migration and Activation: Distinct Effects of Full Length OPN, N- and C-Terminal Fragments" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1B |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bone Sialoprotein & Dentin Matrix Protein 1 |
| Discussion Leader: Marc McKee (McGill University) |
7:30 pm - 8:00 pm | Jaro Sodek (University of Toronto)
"BSP: an Overview and Update" |
8:10 pm - 8:40 pm | Jane Aubin (University of Toronto)
"Phenotype of the BSP Null Mouse" |
8:50 pm - 9:20 pm | Anne George (University of Illinois at Chicago)
"DMP1: Overview & New Ideas" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The CCN Family |
| Discussion Leader: Stephen Lam (University of Illinois at Chicago) |
9:00 am - 9:10 am | Stephen Lam (University of Illinois at Chicago)
"Introduction to the CCN Family" |
9:10 am - 9:40 am | Lester Lau (University of Illinois at Chicago)
"CNN-Integrin Interactions and Cell Signaling" |
9:50 am - 10:20 am | Karen Lyons (University of California, Los Angeles)
"Genetic Analysis of CCN1 & CCN2 in Skeletal Development" |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | David Brigstock (Children's Research Inst., Columbus, Ohio)
"CCN2 in Fibrosis" |
11:40 am - 12:30 pm | Short Poster Talks IV |
| Colette Inkson "Wnt induced secreted protein 1 (WISP-1) Splice Variants and Possible Relationship with BMP Signalling" |
| Cecile Martinerie "Role of NOV/CCN3 in myoblasts and chondrocytes adhesion and differentiation" |
| Masaharu Takigawa "CCN2 promotes expression of the differentiated phenotype of auricular chondrocytes in addition to those of growth and articular cartilage cells" |
| Zhen-Yeu Tong "Hepatic inflammation and fibrosis in transgenic mice that over-produce hepatocyte connective tissue growth factor (CTGF)" |
| Diego Butera "Disintegrin-based biomarkers for glanzmann thrombastenia diagnosis" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2A |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | DMP1 and Dentin Sialophosphoprotein |
| Discussion Leader: Lynda Bonewald (Univ. of Missouri, Kansas City) |
7:30 pm - 7:55 pm | Jian Feng (Univ. of Missouri, Kansas City)
"Phenotype of the DMP1 Null Mouse" |
8:05 pm - 8:30 pm | Mary MacDougall (Univ. of Texas Health Science Center, San Antonio)
"DSPP Mutations in Human Diseases" |
8:40 pm - 8:55 pm | Chunlin Qin (Univ. Texas-Houston)
"Post-translational Modifications of DMP1 & DSPP" |
9:00 pm - 9:30 pm | Short Poster Talks V |
| Stephen Harris "The Cis-Regulatory Regions of the SIBLING Proteins, DMP1 and MEPE: Use In Studying Osteocyte Function and Response of Bone to Mechanical Signaling" |
| Abdullah Karadag "Dentin Matrix Protein 1, Matrix Metalloproteinase-9, Integrins, CD44, and signalling in Colon Cancer Cells Invasion" |
| David Waltregny "Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DSPP, Matrix Extracellular Phosphoglycoprotein & Hot Topics |
| Discussion Leader: Michel Goldberg (Universite Paris V) |
9:00 am - 9:25 am | Taduru Sreenath (NIDCR/NIH, Bethesda, MD)
"Phenotype of the DSPP Null Mouse" |
9:35 am - 10:00 am | Peter Rowe (Univ. of Kansas Medical Center)
"Update of MEPE Biochemistry & Function" |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Thomas Brown (Pfizer, Groton, Connecticut)
"Phenotype of the OF45/MEPE Null Mouse" |
11:15 am - 11:30 am | Kristian P. Doyle (Oregon Health & Science University)
"Osteopontin: A Novel Neuroprotectant for Stroke Therapy" |
11:40 am - 11:55 am | Susie K. Nilsson (Australian Stem Cell Centre)
"Osteopontin Regulates Haemopoietic Stem Cells via Beta-1-Alpha-4 & Beta-1-Alpha-9" |
12:05 pm - 12:20 pm | Gopal C. Kundu (Pune University Campus, Maharashtra, India)
"Deciphering the Molecular Mechanism Involved in Tumor Progression by Metastatic Gene, Osteopontin" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2B |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Special Banquet Speaker |
| Discussion Leader: Larry Fisher (NIDCR/NIH) |
7:30 pm - 8:30 pm | Jay W. Fox (University of Virginia)
"Snake Venoms: Integrins, Disintegrins and MMPs" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |