SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | New Developments in B12 Chemistry and Biology |
| Discussion Leader: Bernhard Kräutler (University of Innsbruck, Austria) |
7:45 pm - 8:15pm | Bernard Golding (University of Newcastle upon Tyne, United Kingdom)
"Coenzyme B12 mechanisms: a done deal or back to the drawing board?" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 9:05 pm | Michael Wiener (University of Virginia, USA) "Active transport of cobalamin across the outer membrane of Gram-negative bacteria: structural answers and mechanistic questions" |
9:05 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Mechanisms of B12-dependent enzymes
(Tribute to Martha Ludwig) |
| Discussion Leaders: Rowena Matthews (University of Michigan, USA) and Cathy Drennan (MIT, USA) |
9:00 am - 9:30 am | Ruma Banerjee (University of Nebraska, USA)
"B12 trafficking in mammals" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Angela Fleischhacker (University of Michigan, USA)
"The ligand trans effect governs conformation in cobalamin-dependent methionine synthase" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | George Reed (University of Wisconsin, USA)
"Isotopic probes of the kinetic mechanisms and of structures of radical intermediates in adenosylcobalamin-dependent eliminases" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Tom Bobik (Iowa State University, USA) "Microcompartments for B12-dependent enzymes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Spectroscopy and Theory |
| Discussion Leader: Neil Marsh (University of Michigan, USA) |
7:30 pm - 8:00 pm | David Smith (Rudjer Boskovic Institute Zagreb, Croatia) "Theoretical Studies of Coenzyme B12-Dependent Reactions: What Can Small Models Tell Us?" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Roseanne Sension (University of Michigan, USA)
"The influence of environment on the electronic structure and dynamics of cob(III)alamins" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Thomas Brunold (University of Wisconsin, USA) "Spectroscopic and computational insights into the mechanism of enzymatic Cob(II) -> Cob(I)alamin reduction" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | B12 in Medicine and Toxicology I |
| Discussion Leader: Søren Moestrup (University of Ärhus, Denmark) |
9:00 am - 9:35 am | David Rosenblatt (McGill University, Canada)
"Combined homocystinuria and methylmalonic aciduria: lessons from MMACHC" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Brian Fowler (University of Basel, Switzerland)
"Homocystinuria and methylmalonic aciduria: MMADHC, one gene, three phenotypes" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Joshua Miller (University of California, Davis, USA)
"Synthesis of 14C-Cyanocobalamin for Assessment of Vitamin B12 Absorption and Bioavailability in Humans" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Mette Madsen (University of Ärhus, Denmark)
"Structural findings illustrating important functional aspects of the vitamin B12-intrinsic factor receptor proteins; cubilin and amnionless" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Corphins |
| Discussion Leader: Bernhard Jaun (ETH-Zürich) |
7:30 pm - 8:00 pm | Stephen Ragsdale (University of Nebraska, USA)
"Methyl-nickel or methyl radical? Nuts, bolts, and wires to trap intermediates involved in the anaerobic oxidation and biosynthesis of methane" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Marc Zimmer (Connecticut College, USA)
"F430 a tetrapyrrole in the entatic state" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Evert Duin (Auburn University, USA)
"Probing the reactivity of Ni in the active site of methyl-coenzyme M reductase" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biosynthesis and uptake (Tribute to Ian Scott) |
| Discussion Leader: Tetsuo Toraya (Okayama University) |
9:00 am - 9:30 am | Martin Warren (University of Kent, United Kingdom) "Aspects of corrin ring biosynthesis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Michi Taga (MIT, USA)
"Biosynthesis of cobalamin's lower ligand by the 'flavin destructase' enzyme BluB" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee break |
11:00 am - 11:30 am | Alison Smith (Cambridge University, United Kindom)
"Algae need vitamins too: the role of vitamin B12 in algae, and how they acquire it from bacteria" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Poster talk 1: Markos Koutmos (University of Michigan, USA) "Structures of the C-terminal Half of Methionine Synthase in the Reactivation Conformation Reveal His759 Environment" |
12:05 pm - 12:25 pm | Poster talk 2: Narayanasami Sukumar (Argonne National Laboratory, USA) "Structural Studies on Human Intrinsic Factor - Cobalamin Complex" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | B12 in Medicine and Toxicology I |
| Discussion Leader: Ralph Green (UC Davis, USA) |
7:30 pm - 8:00 pm | Andrew McCaddon (Univ. of Wales College of Medicine, United Kingdom)
"Vitamin B12 and cognition in the elderly" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Chuck Grissom (University of Utah, USA)
"Cobalamin the Hormone: How we Overlooked the 800 Pound Gorilla in the Room" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Wolfgang Herrmann (Hospital of the Saarland, Germany) "Cobalamin in non-traditional body fluids; relation to blood cobalamin" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Model systems |
| Discussion Leader: Ken Brown (Ohio University, USA) |
9:00 am - 9:30 am | Rudi van Eldik (Erlangen University, Germany)
"Mechanistic information on the interaction of Vitamin B12 and model complexes with NO and nitrite" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Kris McNeill (University of Minnesota, USA)
"Cobalamin-inspired dechlorination catalysts" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee break |
11:00 am - 11:30 am | Roger Alberto (University of Zürich, Switzerland)
"B12 as a carrier for metal complexes" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Poster talk 3: Luciana Hannibal (Kent State University, USA) "Synthesis and x-ray crystal structure of nitroxylcobalamin: The elusive nitric oxide derivative of vitamin B12" |
12:05 pm - 12:25 pm | Poster talk 4: Sofia Gallo (University of Zürich, Switzerland) "Structural rearrangement of the btuB riboswitch of E. coli upon binding to different B12 derivatives" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Perspective and Prospects |
| Discussion Leader: Wilfred van der Donk (University of Illinois, USA) |
7:30 pm - 8:15 pm | John Roth (UC Davis, USA) "Some biological thoughts on B12 use and synthesis" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Ebba Nexo (Ärhus University Hospital, Denmark)
"An incomplete roadmap for vitamin B12 in the human body" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |