SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:30 pm | Welcome Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | B12: NEW DEVELOPMENTS IN MEDICINE & BIOLOGY |
| Discussion Leader: Wilfred van der Donk (University of Illinois, Urbana, USA) |
7:40 pm - 8:20 pm | Roy Gravel (University of Calgary, Alberta, Canada)
"Human Disorders of Vitamin B12 Utilization: Eight Complementation Groups, Eight Genes" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Martin Warren (University of Kent, Canterbury, UK)
"Biosynthesis of the Corrin Ring" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | B12: TRANSPORT & UPTAKE IN HUMANS |
| Discussion Leader: Ebba Nexø (Aarhus University Hospital, Denmark) |
9:00 am - 9:30 am | David Alpers (Washington University School of Medicine, St. Louis, USA)
"Gastric Intrinsic Factor: Lessons from its Biology and Structure" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Roger Schibli (ETH Hönggerberg, Zürich, Switzerland)
"Development of B12 Derivatives for Selective Cancer Cell Targeting" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break / Group Photo |
11:00 am - 11:30 am | Søren Moestrup (University of Aarhus, Denmark) "Membrane Proteins Determining the Transport of Cbl between the Intracellular and Extracellular Compartments" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Edward Quadros (SUNY Downstate Medical Center, Brooklyn, USA)
"The Transcobalamin Receptor Mediated Cellular Uptake of Vitamin B12" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session (Group A) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | B12-UPTAKE AND USE IN BACTERIA |
| Discussion Leaders: Charles Grissom (University of Utah, Salt Lake City, USA) and Helga Refsum (University of Oslo, Norway) |
7:30 pm - 7:55 pm | Christof Holliger (École Polytechnique Fédéral de Lausanne, Switzerland)
"Maturation and Export of the Corrinoid-Containing Tetrachloroethene Reductive Dehalogenase" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Michael Wiener (University of Virginia, Charlottesville, USA)
"Active Transport of Corrinoids Across the Gram-Negative Bacterial Outer Membrane: New Structural and Functional Results" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Atica Moosa (University of the Witwatersrand) "The metabolism of vitamin B12 in Mycobacterium tuberculosis: role of alternate B12 cofactors" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Katrine Hygum (Aarhus University Hospital) "In mice transcobalamin stands in for haptocorrin" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | B12 IN MEDICINE & TOXICOLOGY |
| Discussion Leader: Ralph Green (University of California, Sacramento, USA) |
9:00 am - 9:30 am | Frank Rutsch (Universitätsklinikum Münster, Germany)
"New Insights into Lysosomal Cobalamin Trafficking: Lessons Learned from CbIF Disease" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Joshua Miller (University of California, Davis) "Physiological doses of cyanocobalamin are modified or degraded in the gastrointestinal tract" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Jacob Selhub (Tufts University, Boston, USA)
"Folic Acid Intake and the Exacerbation of B12 Deficiency" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Lawrence Solomon (Yale University, New Haven, USA)
"Oxidant Stress as a Cause of 'Functional' Cobalamin Deficiency and its Possible Clinical Significance" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session (Group A) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | B12: STRUCTURES, SPECTROSCOPY AND THEORY |
| Discussion Leader: Tetsuo Toraya (University of Okayama, Japan) |
7:30 pm - 7:55 pm | Sergey Fedosov (University of Aarhus, Denmark)
"Exotic Blue Corrinoid - the Major Product of Near Physiological Hydrolysis of Vitamin B12" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Alex Jones (University of Manchester, UK) "Catalysis in Adenosylcobalamin-Dependent Ethanolamine
Ammonia Lyase - a Magnetic Field Effects Study" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | David Smith (Rudjer Boskovic Institute, Zagreb, Croatia)
"A Computational Perspective on Glycerol Dehydration: To B12 or not to B12" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Kazunari Yoshizawa (Kyushu University, Fukuoka, Japan)
"Computational Mutation of the Structure and Reactivity of B12- Dependent Diol
Dehydratase" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | MECHANISMS OF B12-ENZYMES I: MUTASES |
| Discussion Leader: Wolfgang Buckel (University of Marburg, Germany) |
9:00 am - 9:30 am | Bernard T. Golding (University of Newcastle, UK)
"The Evolution of Mechanistic Ideas for Coenzyme B12" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Antonio Pierik (Philipps University, Marburg, Germany)
"Chasing and Catching Radicals by EPR" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Naoki Shibata (University of Hyogo, Japan)
"Crystal Structure Analysis and Insight into the Reaction Mechanism of Ethanolamine Ammonia-Lyase" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Kurt Warncke (Emory University, Atlanta, USA)
"Molecular Mechanistic Features of Coenzyme B12-Dependent Enzyme Catalysis Revealed by Time-Resolved Electron Paramagnetic Resonance (EPR) and Optical Absorption Spectroscopy" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session (Group B) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MECHANISMS OF B12-ENZYMES II: RIBONUCLEOTIDE REDUCTASE |
| Discussion Leader: Kenneth Brown (Ohio University, Athens, USA) |
7:30 pm - 8:10 pm | Catherine L. Drennan (Massachusetts Institute of Technology, Cambridge, USA)
"Crystallographic Snapshots of a Class II Ribonucleotide Reductase" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Gary J. Gerfen (Yeshiva University, New York, USA)
"Studies of Allostery and Inhibition in B12-Dependent Ribonucleoside Triphosphate Reductase" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm -9:20 pm | Derek Logan (Lund University, Sweden)
"Structural Studies on B12 Bond Cleavage in Class II Ribonucleotide Reductases" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | CORPHINS |
| Discussion Leaders: Rudolf K. Thauer (University of Marburg, Germany) and Yoshio Hisaeda (Kyushu University, Fukuoka, Japan) |
9:00 am - 9:30 am | Bernhard Jaun (ETH Zürich, Switzerland)
"New Insights into the Catalytic Mechanism of Methyl-Coenzyme M Reductase" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Stephen Ragsdale (University of Michigan, Ann Arbor, USA)
"Evidence for Organometallic and Radical Intermediates in Corphin-Dependent Methane Synthesis" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:05 am | Michael Gray (University of Wisconsin, Madison) "CbiZ is required for salvaging of pseudocobalamin in Rhodobacter sphaeroides" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Yan Kung (MIT, Cambridge, USA) "Crystal structure of a protein complex involved in B12-dependent methyl transfer" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Keishiro Tahara (Kyushu Univeristy) "A New B12 Catalytic System Using Organic Polymeric Scaffold" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Kirsten Wolthers (University of Manchester) "Catalysis linked to domain dynamics in adenosylcobalamin dependent ornithine 4,5-aminomutase" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 5:30 pm | Poster Session (Group B) |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | PERSPECTIVE & PROSPECTS |
| Discussion Leader: Bernhard Kräutler (University of Innsbruck, Austria) |
7:30 pm - 8:15 pm | Robert Doyle (Syracuse University, Syracuse, USA)
"Exploring the Implications of Vitamin B12 Conjugation to Insulin on Insulin Receptor Binding and Cellular Uptake" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Ruma Banerjee (University of Michigan, Ann Arbor, USA)
"The Tinkers, Tailors and Mailmen in Mammalian Vitamin B12 Assimilation" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Depart |