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Barrier Function of Mammalian Skin
Gordon Research Conference

Defining, Investigating and Surmounting the Barrier

Dates

August 16-21, 2015

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Dennis R. Roop & Reinhard H. H. Neubert

Vice Chairs:
Samir S. Mitragotri & Joachim W. Fluhr

Application Deadline

The application deadline for this meeting was July 19, 2015. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

The 14th Barrier Function of Mammalian Skin Gordon Research Conference is scheduled for August 16-21st, 2015 at the Waterville Valley Resort in New Hampshire, USA. This conference represents the primary international research forum on the mammalian barrier, and is focused on biophysical, biological, and clinical aspects of barrier formation and function in health and disease. To highlight important and novel perspectives, the organizers have assembled an outstanding list of speakers, and will again highlight a "Late-Breaking Topics / Young Investigators" session, wherein six-to-seven presentations will be given by young scientists, describing their most-recent research.

This popular conference is generally fully- to-over-subscribed, which makes it possible to accept an optimal mix of attendees from academics, industry and government, as well as a mix of young and established scientists. Submitted abstracts will be used not only to assist with consideration for conference participation, but also for the selection of presenters for the "Late-Breaking Topics" session. The organizers have made a concerted effort to recruit speakers and encourage attendees from around the world.

This Barrier Gordon Conference will provide new insights into the origin, function, maintenance, and repair of the mammalian skin barrier, including the penetration of drugs and exclusion of toxins and pathogens. An array of important topics has been selected, with sessions and/or presentations devoted to: Normal and Pathological Responses to Barrier Disruption, Overcoming the Barrier in Delivering Therapeutics, Regulating Barrier Formation and Maintenance, New Technology Platforms for Investigating the Barrier, Itch and the Epidermal Barrier, Stratum Corneum Structure and Function, and Skin Barrier in Health and Disease. To complement these diverse themes, four evening poster sessions are scheduled, with up to 30 presentations each. In addition, a stimulating and entertaining Discussion Forum, on the topic "In Vitro vs. In Vivo Models of Barrier Function” is scheduled for the final evening.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Progress in Defining, Investigating and Surmounting the Barrier
Discussion Leaders: Theodora Mauro (University of California, San Francisco, USA) and Philip Wertz (University of Iowa, USA)
7:40 pm - 8:05 pmPeter Elias (Veterans Administration Medical Center / University of California, San Francisco, USA)
"Epidermal Protective Functions: An Integrated View of Skin Defense"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRichard Guy (University of Bath, United Kingdom)
"Imaging Drug Delivery to Skin and Nail with Micro(spectro)scopic Techniques"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmLars Norlen (Karolinska Institute, Sweden)
"Molecular Organization of Skin Barrier Formation"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNormal and Pathological Responses to Barrier Disruption
Discussion Leaders: Steven Hoath (University of Cincinnati, USA) and Maria Morasso (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
9:00 am - 9:30 amAllan Balmain (University of California, San Francisco, USA)
"Genetic Control of Skin Barrier Function, Inflammation and Carcinogenesis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amFiona Watt (Kings College London, United Kingdom)
"How Differentiated Epidermal Cells Influence Cancer Susceptibility"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:30 amIrwin McLean (University of Dundee, United Kingdom)
"Filaggrin in Health and Disease"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmFrank Nestle (King's College London, United Kingdom)
"Factors Influencing the Balance Between Skin Immune Homeostasis and Pathology"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOvercoming the Barrier in Delivering Therapeutics
Discussion Leaders: Gerald Kasting (University of Cincinnati, USA) and Erwin Tschachler (Medical University of Vienna, Austria)
7:30 pm - 7:50 pmAdrian Davis (Limeway Pharma Design Ltd., United Kingdom)
"Improved Patient Adherence by Taking Back Control from the Skin Barriers"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMike Farwick (Evonik Industries, Germany)
"Compositions of Cosmetic Formulations and Their Influence on the Bioavailability of Active Ingredients"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAmy Paller (Northwestern University, USA)
"Nanoconstructs as Topical Gene Therapy for Skin Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSamir Mitragotri (University of California, Santa Barbara, USA)
"Ionic Liquids for Transdermal and Topical Drug Delivery"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulating Barrier Formation and Maintenance
Discussion Leaders: Nava Dayan (Dr. Nava Dayan L.L.C., USA) and Cristina De Guzman Strong (Washington University School of Medicine, USA)
9:00 am - 9:30 amMasayuki Amagai (Keio University School of Medicine, Japan)
"Dissecting Skin Barrier Dysfunction as a Cause of Dermatitis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amThomas Magin (University of Leipzig, Germany)
"Keratins as Integrators of Cornified Envelope Regulation and Function"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amCarien Niessen (University of Cologne, Germany)
"Metabolic Regulation of Skin Barrier Formation and Function"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSabine Werner (ETH Zurich, Switzerland)
"Cytoprotective Signaling Pathways in the Control of Barrier Function"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Technology for Investigating / Penetrating the Barrier
Discussion Leaders: Marek Haftek (University of Lyon / CNRS, France) and Michael Roberts (University of South Australia / University of Queensland, Australia)
7:30 pm - 7:50 pmRoger Kaspar (TransDerm, USA)
"Overcoming the Barrier – Development of Delivery Technologies for Potential Pachyonychia Congenita Therapeutics"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKevin Mills (Procter and Gamble Company, USA)
"Molecular Profiling in Health and Disease: Utility in Discovery of Agents to Improve Skin Condition"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmXiao-Jing Wang (University of Colorado, Denver, USA)
"Smad7-Based Therapeutics for Chronic Wound Healing"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGabriel Wittum (Goethe Center for Scientific Computing, Goethe University Frankfurt, Germany)
"In Silico Modeling the Barrier Function of Human Skin"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmItch and the Epidermal Barrier
Discussion Leaders: Lisa Beck (University of Rochester Medical Center, USA) and Ellen Lumpkin (Columbia University, USA)
9:00 am - 9:30 amEthan Lerner (Harvard University School of Medicine, USA)
"Understanding Itch: Are We There Yet?"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amSarah Ross (University of Pittsburgh, USA)
"The Neural Basis for Itch and Its Inhibition by Counter Stimuli"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amGiuseppe Lauria (Foundation I.R.C.C.S., Institute of Neurology, Milano, Italy)
"The Skin as a Nociceptor"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmRichard Anderson (Wellman Center for Photomedicine, USA)
"A Novel Therapeutic Approach for Itch"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics / Young Investigator Presentations
This session will have eight presentations (10 minutes duration, 5 minute discussion) to be selected from the abstracts received.
Discussion Leaders: Joachim Fluhr (Charité - Universitätsmedizin Berlin, Germany) and Reinhard H. Neubert (Martin Luther University Halle-Wittenberg, Germany)
7:30 pm - 8:30 pmLate-Breaking Topics
8:30 pm - 9:30 pmShort Talks Selected from Poster Abstracts
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStratum Corneum Structure and Function: What Is New?
Discussion Leaders: Joke Bouwstra (Leiden Academic Centre for Drug Research (LACDR), The Netherlands) and Juergen Lademann (Charité - Universitätsmedizin Berlin, Germany)
9:00 am - 9:30 amGerald Brezesinski (Max Planck Institute, Potsdam-Golm, Germany)
"Interaction of Ceramides and Their Mixtures with Penetration Enhancers: A Monolayer Approach"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAlain Hovnanian (INSERM UMR1163, Imagine Institute, France)
"Protease-Mediated Signaling Cascades and Their Regulation in the Skin"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amDaniel Huster (University of Leipzig, Germany)
"Investigation of the Structure and Phase Bahavior of Stratum Corneum Models by Solid-State NMR Spectroscopy"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmAndrzej Slominski (University of Alabama at Birmingham, USA)
"Cutaneous Melatoninergic and Secosteroidogenic Systems as Protectors of Epidermal Integrity"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSkin Barrier in Health and Disease / In Vitro vs. In Vivo Models of Barrier Function
Discussion Leaders: Heidi Kong (National Cancer Institute, NIH, USA), Birgit Lane (Institute of Medical Biology, Singapore), Walter Holleran (Veterans Administration Medical Center / University of California, San Francisco, USA) and Gopinathan Menon (ASI Corporation, USA)
7:30 pm - 8:00 pmMatthew Hardman (University of Manchester, United Kingdom)
"The Host-Microbiota Axis in Skin Wound Repair"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSpiro Getsios (Northwestern University, USA)
"Perspectives on a Top-Down Approach"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJonathan Garlick (Tufts University, USA)
"Perspectives on a Bottom-Up Approach"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmArup Indra (Oregon State University / Oregon Health and Science University, USA)
"Epidermal Lipids in Barrier Integrity : From Animal Models to Humans"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJerrold Turner (The University of Chicago, USA)
"Tight Junctions in Regulation of Epithelial Barrier and Pathogenesis of Crohn’s Disease"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (I1 R13AR068231-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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