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Epithelial Differentiation & Keratinization
Gordon Research Conference

Epithelial Interactions in Development, Homeostasis, Disease and Therapy

Dates

May 7-12, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy Site Information

Organizers

Chair:
Carien M. Niessen

Vice Chair:
Valentina Greco

Application Deadline

The application deadline for this meeting was April 9, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

In 2017 the Gordon Research Conference on Epithelial Differentiation and Keratinization will return to Italy's beautiful Tuscany with close by old and charming villages such as Luca and the very comfortable Renaissance Tuscany Il Ciocco Resort and Spa. This will provide the perfect setting to stimulate discussions on the latest developments presented in this leading epithelial biology meeting.

The goal of the conference entitled, "Epithelial interactions in development, homeostasis, disease and therapy", is to bring together word class leading experts, young and upcoming PIs, students and postdocs in an open atmosphere that promotes the exchange and dissemination of new research concepts and opportunities at the forefront of epithelial biology. The aims of the 2017 Conference are to define the most important scientific problems in our field, further the development of young investigators, promote interactions and discussions at posters and throughout the meeting and introduce and incorporate new concepts and advances from other fields. To accomplish these goals, the 2017 program for 2017 will focus on novel and emerging concepts in epithelial function and in epithelial-based therapeutics emphasizing. The meeting will start with a keynote session on dynamic interactions in tissue homeostasis and disease. Subsequent sessions will focus on presentations from leading scientists and young investigators at the forefront of investigation in: homeostatic growth of epithelia, the development and evolution of skin and its appendages, mechanisms of epithelial carcinogenesis, advances in epithelial homeostasis and regeneration, current ideas on cellular cross talk within epithelial tissues, novel discoveries in the regulation of cell and tissue architecture, new insights into stress responses and epithelial aging, and novel epithelial based therapies for cancer, tissue regeneration, and autoimmune disorders.

Attending will be an outstanding cadre of interactive and dynamic speakers including basic researchers and clinicians, young and established scientists, and scientists from academia and industry. At least half of this year's speakers will differ from the last meeting and approximately 30% of the talks will be selected from submitted abstracts, ensuring that the latest conceptual and technical developments will be presented in the program. Importantly, the Conference continues to feature an associated Gordon Research Seminar starting the day prior to the meeting, providing an outstanding opportunity for young scientists to network and present their research, in addition to attending the main Conference.

GRC Short Talk Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for one of the Short Talk presentation slots should submit their application by March 1, 2017.

Related Meeting

This GRC will be held in conjunction with the "Epithelial Differentiation & Keratinization" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmVisualizing Interactions in Epithelial Homeostasis and Disease
Discussion Leaders: Kathleen Green (Northwestern University, USA) and Aaron Mertz (Rockefeller University, USA)
7:40 pm - 8:20 pmRonald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Using Advanced Dynamic and Multiplex Static Imaging to Understand Tissue Organization and Function"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmAngela Christiano (Columbia University, USA)
"Therapeutic and Genetic Approaches to Alopecia Areata and Skin Blistering Diseases"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHomeostatic Growth and Regeneration of Epithelia: Novel Concepts in Cell Death and Renewal
Discussion Leaders: Valerie Horsley (Yale University, USA) and Maria Morasso (National Institutes of Health, USA)
9:00 am - 9:20 amJay Rajagopal (Massachusetts General Hospital, USA)
"Plasticity and Epithelial Regeneration"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPhilip Jones (The Wellcome Trust Sanger Institute, United Kingdom)
"Clonal Competition in Squamous Carcinogenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amKim Jensen (University of Copenhagen, Denmark)
"Cellular Reprogramming by Defined Factors Drives Tissue Repair Following Injury of the Intestinal Epithelium"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amPantelis Rompolas (University of Pennsylvania, USA)
"Eye to Eye: Visualizing Stem Cell Activity and Regeneration of the Live Corneal Epithelium"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amEugenia Piddini (University of Cambridge, United Kingdom)
"Mechanisms and Function of Cell Competition in Health and Disease"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amAron Jaffe (Novartis Institutes for BioMedical Research, USA)
"Single Cell RNA-Seq Reveals a Novel Cell Type in Airway Epithelium"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSarah Millar (University of Pennsylvania, USA)
"Distinct Functions for Class I HDACs in Epithelial Progenitor Cell Self-Renewal and Differentiation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Angela Christiano (Columbia University, USA) and Valentina Greco (Yale University, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmEvolution and Morphogenesis of Skin and Its Appendages
Discussion Leaders: Cristina De Guzman Strong (Washington University School of Medicine, USA) and Bogi Andersen (University of California, Irvine, USA)
6:00 pm - 6:20 pmChristiane Nuesslein-Volhard (Max Planck Institute for Developmental Biology, Germany)
"The Development and Evolution of Colour Patterns in Fishes"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmLeopold Eckhart (Medical University of Vienna, Austria)
"Diversification of Epidermal Differentiation Proteins During the Evolution of the Skin in Mammals, Reptiles and Birds"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmCheng-Ming Chuong (University of Southern California, USA)
"Evo-Devo of Skin Stem Cells and Their Regulation"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmElena Ezhkova (Icahn School of Medicine at Mount Sinai, USA)
"Diverse Roles of Polycomb Repressive Complexes in Epidermal Stem Cell Maintenance and Differentiation"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmAnthony Oro (Stanford University, USA)
"Chromatin Dynamics During Epithelial Commitment"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCancerous Growth, Migration and Invasion of Epithelia
Discussion Leaders: Pritinder Kaur (Curtin University, Australia) and Scott Atwood (University of California, Irvine, USA)
9:00 am - 9:20 amPeter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Plasticity of Collective Invasion in Epithelial and Mesenchymal Cancer Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amElaine Fuchs (Rockefeller University, USA)
"Skin Stem Cells and Their Niche Interactions in Homeostasis and Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAllan Balmain (University of California, San Francisco, USA)
"Target Genes and Target Cells in Skin Cancer"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amShort Talk Selected from Poster Abstracts
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amAndrzej Dlugosz (University of Michigan, USA)
"Molecular Basis of Merkel Cell Carcinoma"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amBrian Capell (University of Pennsylvania, USA)
"Epigenetic Enhancers and SCC"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmCedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Cancer Cell of Origin, Multipotency and Tumor Heterogeneity in the Mammary Gland"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenetic and Epigenetic Determinants of Cell Fate
Discussion Leaders: Xiaomin Bao (Northwestern University, USA) and Jennifer Zhang (Duke University, USA)
6:00 pm - 6:20 pmDouglas Winton (Cancer Research UK Cambridge Institute, United Kingdom)
"Distinguishing Plasticity from Fate During Intestinal Self Renewal"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmPaul Khavari (Stanford University, USA)
"RNA and Protein Regulators of Ras Pathway and Signaling"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmTing Chen (National Institute of Biological Sciences, Beijing (NIBS), China)
"Hox Demarcates Regional Regeneration of Skin"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmVladimir Botchkarev (University of Bradford, United Kingdom / Boston University, USA)
"Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Cell Fate Maintenance and Suppresses Inflammatory Responses in the Epithelium of Developing and Adult Skin"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmTudorita Doina Tumbar (Cornell University, USA)
"Genetic and Epigenetic Regulation of Skin Epithelial Stem Cell Lineages in and out of Their Niches"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Cell- and Tissue-Architecture Control
Discussion Leaders: Birgit Lane (Institute of Medical Biology, A*STAR, Singapore) and Srikala Raghavan (Institute for Stem Cell Biology and Regenerative Medicine, India)
9:00 am - 9:20 amRoberto Mayor (University College London, United Kingdom)
"Collective Cell Migration in Development"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amMatthias Ruebsam (University of Cologne, Germany)
"Cadherins Are Key Determinants of Epidermal Polarity and Tension"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amCory Simpson (University of Pennsylvania, USA)
"The Mitophagy Receptor NIX Is Unregulated During Epidermal Differentiation and Drives Mitochondrial Fragmentation via Drp1"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amSara Wickstrom (Max Planck Institute for Biology of Aging, Germany)
"Biomechanics of Stem Cell Fate Regulation"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amScott Williams (University of North Carolina at Chapel Hill, USA)
"Rugged Terrain: The Search for Oral Epithelial Stem Cells"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amPierre Coulombe (Johns Hopkins Bloomberg School of Public Health, USA)
"Interplay Between Intermediate Filaments and Redox Balance in Disease"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amOxana Nekrasova (Northwestern University, USA)
"Desmosomal Cadherin Association with Tctex-1 and Contraction-Arp2/3 Drives Perijunctional Actin Polymerization to Promote Epidermal Stratification"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmTerry Lechler (Duke University Medical Center, USA)
"Novel Functions for Desmosomes in the Epidermis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCellular Stress Responses in Homeostasis and Degeneration
Discussion Leaders: Markus Schober (New York University School of Medicine, USA) and Marina Mapelli (European Institute of Oncology, Italy)
6:00 pm - 6:20 pmPekka Katajisto (Karolinska Institutet, Sweden / University of Helsinki, Finland)
"Age-Selective Segregation of Organelles During Stem Cell Division"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmCarlos Clavel (A*Star-Institute of Medical Biology, Singapore)
"Regulation of the Hair Follicle Stem Cell Niche During Hair Growth, Pigmentation and Aging"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmMichaela Frye (University of Cambridge, United Kingdom)
"Translating Epitranscriptome in Skin Stem Cells"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmKiarash Khosrotehrani (University of Queensland, Australia)
"Bimodal Evolution of Clone Size Variation in the Interfollicular Epidermis Persists upon UVB Irradiation: Implications for Carcinogenesis"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmManolis Pasparakis (University of Cologne, Germany)
"Epithelial Cell Death Pathways in Inflammatory Diseases"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmEpithelia Micro-Environment in Homeostasis and Disease
Discussion Leaders: Michael Rendl (Icahn School of Medicine at Mount Sinai, USA) and Chloe Feral (INSERM, France)
9:00 am - 9:20 amJan Philipp Junker (Max Delbruck Center for Molecular Medicine, Germany)
"Spatial Transcriptomics and Single-Cell Lineage Tracing"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFiona Watt (King's College London, United Kingdom)
"Fibroblast Heterogeneity in Skin Homeostasis and Disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amShort Talk Selected from Poster Abstracts
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amValentina Greco (Yale University, USA)
"Principles of Skin Tissue Regeneration by Live Imaging"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amHironobu Fujiwara (Center for Developmental Biology, RIKEN, Japan)
"Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amEllen Lumpkin (Columbia University, USA)
"Neurobiology of Touch"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmGeorge Cotsarelis (University of Pennsylvania, USA)
"Hair Follicle Stem Cells in Androgenetic Alopecia"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNovel Translational Concepts in Epithelial Based Disease
Discussion Leaders: Dennis Roop (University of Colorado Anschutz Medical Campus, USA) and Sunny Wong (University of Michigan, USA)
6:00 pm - 6:20 pmGraziella Pellegrini (University of Modena and Reggio Emilia, Italy)
"Stem Cell Therapy for Corneal Burns"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmAkiharu Kubo (Keio University, Japan)
"Causative Gene Identification and Pathogenesis-Based Therapies in Genodermatoses"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmCaterina Missero (CEINGE - Biotecnologie Avanzate / University of Naples Federico II, Italy)
"Novel Approaches to Target p63-Associated Genodermatoses"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:35 pmJulie Segre (National Human Genome Research Institute, NIH, USA)
"Translating Human Skin Microbiome Research for Primary Immune Deficiency and Atopic Dermatitis Patients"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSalvador Aznar Benitah (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"Epigenetic Control of CD36+ Metastasis Initiating Cells by Dietary Fatty Acids"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (1 R13AR71766-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS) and all co-funding support provided by the National Center for Advancing Translational Sciences (NCATS).The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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