Gordon Research Conferences
Meeting Details
Search:
  GO

Fertilization and Activation of Development
Gordon Research Conference

Where Basic Meets Clinical Meets Mechanism

Dates

July 19-24, 2015

Location

Holderness School
Holderness, NH

Organizers

Chair:
Gary Wessel

Vice Chair:
Mariana F. Wolfner

Meeting Description

One of the most dramatic transitions in the life history of an organism occurs with the union of egg and sperm. Used by all sexually reproducing organisms, fertilization begins with fusing these two highly specialized cells – from different individuals – and successfully reprogramming the embryo for early development. The study of fertilization and the activation of development requires integration of broad molecular, physiological, and evolutionary aspects that all intersect on the "reproductive niche" of the organism. Moreover, these processes are highly susceptible to the influences of gamete maturation, the environment, the age of the gametes and of the adults, and clinical intervention is needed to address the infertility in over 50 million people worldwide, annually. The awarding of the 2010 Nobel Prize in Physiology or Medicine to Dr. Robert G. Edwards for development of in vitro fertilization underscores this significance and the benefits from the integrative approach to biomedical research.

This is the 21st successive Gordon Research Conference on Fertilization and Activation of Development. Its participants will explore the latest advances in the field that render the gametes "fertilization-competent," and the transition into embryonic development. An emphasis of this conference is to provide broad perspectives from different organisms – plants and animals – using different technologies and research approaches, through an evolutionary lens.

The scientific program for the 2015 Gordon Conference brings together researchers from basic, veterinary, and clinical perspectives to share scientific advances and future plans in reaching our goals of understanding this important transitional period in an organism’s life history. The Conference also provides a link with a Gordon Research Seminar - a forum for graduate students, post-doctoral fellows, and early career scientists to present their work in the field immediately preceding the Conference. Topics to be discussed in these gatherings include sperm and oocyte maturational processes and aging; gamete union, competition and evolution; early embryogenesis; and reproductive epigenetics and the environmental impacts on fertility. Approximately half of the presentations will be from invited speakers whereas other talks will be selected from the abstract submissions, with a focus on exciting late-breaking results. Keynote talks will address broad topical considerations in the field and unique experimental approaches to stimulate future research. Please join us for these exciting forums of discussion and discovery.

Related Meeting

This GRC was held in conjunction with the "Fertilization and Activation of Development" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTransgenerational Considerations in Reproduction
Discussion Leader: Carmen Williams (National Institute of Environmental Health Sciences, NIH, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmMary Patti (Joslin Diabetes Center, USA)
"Intergenerational Nutrition and Metabolism"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmJennifer Wood (University of Nebraska-Lincoln, USA)
"The Female Obese Phenotype: Increased Ovarian Inflammation and Changes in the Gut Microbiome Regulate the Transcription of Maternal Effect Gene mRNAs"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAntony Jose (University of Maryland, College Park, USA)
"Messages from Ancestors: Inheritance of RNA from Somatic Cells to Progeny in C. elegans"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKatsuhiko Hayashi (Kyushu University, Japan)
"Reconstitution of the Female Germline in a Dish"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMolecular Mechanisms of Male Gamete Function
Discussion Leader: Pablo Visconti (University of Massachusetts, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amJean-Ju Chung (Children's Hospital Boston / Harvard Medical School, USA)
"Novel Components of Ca2+ Signaling in Sperm Hyperactivation"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amHaruhiko Miyata (Osaka University, Japan)
"Ca2+-Dependent Phosphatase and Sperm Motility"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amMartin Matzuk (Baylor College of Medicine, USA)
"Genetic and Drug Discovery Approaches for Male Infertility and Contraception"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amDario Krapf (IBR - CONICET, Argentina)
"cSrc Is the Connecting Player Between PKA Activation and Hyperpolarization in Mouse Sperm"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amChristophe Arnoult (CNRS, France)
"Calcium-Independent iPLA2b and Group X sPLA2 Are Successively Activated During Progesterone-Induced Acrosome Exocytosis"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmJoel Drevet (University Blaise Pascal, France)
"Mouse Sperm Chromosome Susceptibility to Post-Testicular Oxidative DNA Damage: Why, Where, and Consequences"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMeiosis Resumption in the Oocyte
Discussion Leader: Lisa Mehlmann (University of Connecticut Health Center, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmRong Li (Stowers Institute for Medical Research, USA)
"Symmetry Breaking and Asymmetric Meiotic Cell Division in Mouse Oocytes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmTeresa Woodruff (Northwestern University, USA)
"Zinc Regulation of Oocyte Maturation and Early Fertilization Events"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDavid Keefe (New York University Langone Medical Center, USA)
"Chromosome Ends at the Beginning of Life - Telomeres and Reproductive Function"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiversity in Sperm-Egg Interaction Molecules
Discussion Leader: Mark Johnson (Brown University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amGavin Wright (Wellcome Trust Sanger Institute, United Kingdom)
"Sperm Meets Egg: Using Extracellular Protein Interaction Screens to Identify Receptor-Ligand Pairs Involved in Mammalian Gamete Recognition"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amWilliam Snell (University of Texas Southwestern Medical Center, USA)
"Species-Specific Adhesion Receptors Act Prior to a Conserved Putative Fusion Protein During the Gamete Membrane Fusion Reaction in Chlamydomonas"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amKhurts Shilagardi (Johns Hopkins University, USA)
"Novel Function of ABC Transporters in Cell Fusion"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAndrew Singson (Rutgers University, USA)
"Fertilization and Gamete Activation: Gene Discovery in C. elegans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amStefanie Sprunck (University of Regensburg, Germany)
"Gamete Interactions During Double Fertilization in Plants"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmTetsuya Higashiyama (Nagoya University, Japan)
"New Mechanisms and Key Molecules of Plant Double Fertilization Identified by Live-Cell Analyses"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEvolving Views on Sperm and Egg Function
Discussion Leader: Janice Evans (Johns Hopkins University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmLuca Jovine (Karolinska Institutet, Sweden)
"A Molecular Regulator of ZP Domain Protein Polymerization"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmGail Cornwall (Texas Tech University Health Sciences Center, USA)
"Amyloid Properties of the Mouse Zona Pellucida: Implications for Mechanism of Sperm-ZP Binding"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmAlberto Darszon (Universidad Nacional Autonoma de Mexico, Mexico)
"Real Time Monitoring of the Acrosomal Reaction in Human Sperm"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmMatthew Marcello (Pace University, USA)
"Mapping the Interactome of C. elegans Sperm Proteins"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Egg-to-Embryo Transition
Discussion Leader: Karl Swann (Cardiff University School of Medicine, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amToshiro Aigaki (Tokyo Metropolitan University, Japan)
"Molecular Basis of Egg Activation in Drosophila"
9:35 am - 9:45 amDiscussion
9:45 am - 9:55 amJunaid Kashir (Cardiff University, United Kingdom)
"PLCzeta or PAWP? Characterization of Two Sperm Factor Candidates in Mammalian Gametes"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amYuhkoh Satouh (Osaka University, Japan)
"Functional Significance of Sperm Post Acrosomal WW-Domain Protein in Mouse Egg Activation"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amTim Weil (Cambridge University, United Kingdom)
"Do Changes in Intracellular Calcium Concentration Regulate mRNA?"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amEli Arama (Weizmann Institute of Science, Israel)
"Paternal Mitochondrial Destruction in Drosophila"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmAntonio Giraldez (Yale University, USA)
"Gene Regulation During the Maternal to Zygotic Transition"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmThinking Outside the Box with New Technological Advances
Discussion Leader: Gary Wessel (Brown University, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:20 pmRon Weiss (Massachusetts Institute of Technology, USA)
"Synthetic Biological Approaches to Study Real Biological Problems"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmVera Jansen (Center of Advanced European Studies and Research, Germany)
"Controlling cAMP Signaling in Sperm Using Optogenetics"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmAlexander J. Travis (Cornell University, USA)
"From Sperm to Stroke - New Diagnostic Approaches Based on Biomimicry and Nanotechnology"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInfluences of the Reproductive Tract on Fertilization
Discussion Leader: Harvey Florman (University of Massachusetts Medical School, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amSylvie Breton (Massachusetts General Hospital / Harvard Medical School, USA)
"Regulation of Epithelial Cells in the Epididymis"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSusan Suarez (Cornell University, USA)
"Sperm Interactions with the Female Reproductive Tract"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amMichael Miller (University of Alabama at Birmingham, USA)
"Neurosensory Control of Sperm Motility Within the Oviduct"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amGillian Stanfield (University of Utah, USA)
"Sperm and the Female Reproductive Tract Communicate to Influence Sperm Competition and Cryptic Female Choice in C. elegans"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmTodd Macfarlan (National Institute of Child Health and Human Development, NIH, USA)
"Exploring Parental Impacts on Zygotic Genome Activation with RNA-seq"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSperm Competition and Evolution of Reproductive Mechanisms
Discussion Leader: Mariana Wolfner (Cornell University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmHeidi Fisher (University of Maryland, USA)
"The Causes and Consequences of Sperm Competition in Deer Mice"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmWillie Swanson (University of Washington, USA)
"Adaptive Evolution and Coevolution of Sperm - Egg Recognition Molecules"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmSimone Immler (Uppsala University, Sweden)
"The Causes and Consequences of Selection at the Gametic Level in Animals"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by Gran 1R13HD085557-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Sciences; nor does mention by trade names, commercial practices or organizations imply endorsement by the U.S. Government.
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter