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Glycobiology
Gordon Research Conference

Glycans as Mediators of Interactions Between Molecules, Cells and Organisms

Dates

March 1-6, 2015

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Markus Aebi

Vice Chair:
Michael Tiemeyer

Meeting Description

The GRC "Glycobiology" is one of the leading meetings in the research area of glycoconjugates. It offers a collegial setting and provides a unique platform to present the newest developments in the field and to discuss the latest findings in our multidisciplinary area of research. Glycoconjugates carry biological information and are ideally suited to mediate interactions at the molecular and cellular level as well as between organisms. Complex biosynthetic pathways are devoted to the biosynthesis and the degradation of glycoconjugates and recent advances in analytical technologies made it possible to detect the high structural diversity of glycans in all species.

An exceptional and diverse group of international scientists will present at the meeting. Nine scientific sessions will cover diverse areas of the field, including the role of glycans in evolutionary processes, the glycobiology of prokaryotes and parasites, with a special focus on the glycobiology of the gut microbiota. The glycobiology of model organisms, chemical and structural glycobiology, the biosynthesis of glycoconjugates and the role of carbohydrates in health and in disease, the function of carbohydrate-binding proteins, the production of glycoconjugates and carbohydrate-based vaccines as well as the analytics of complex carbohadrates is in the main focus of the meeting. Approximately 30 invited talks, 24 short talks selected from poster abstracts and poster sessions represent the core of the Glycobiology GRC. After the big success of the first seminar in 2013, a Glycobiology Gordon Research Seminar will also be held in advance of the GRC that will foster interactions between graduate students, post-docs and established researchers as mentors.

Related Meeting

This GRC was held in conjunction with the "Glycobiology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGlycans and Evolution
Discussion Leader: Markus Aebi (ETH Zurich, Switzerland)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmSteven Ball (University of Lille, France)
"From Evil to Redemption: Turning an Intracellular Pathogen's Glycogen Metabolism Effectors into the Major Drivers of Plastid Endosymbiosis"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmPascal Gagneux (University of California, San Diego, USA)
"Convergent Glycan Evolution - Patterns in the Glycan Jungle?"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmAjit Varki (University of California, San Diego, USA)
"Human-Specific Evolution of Sialic Acids and Siglecs"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycobiology of Prokaryotes and Unicellular Organisms
Discussion Leader: Richard Cummings (Emory University School of Medicine, USA)
9:00 am - 9:25 amBarbara Imperiali (Massachusetts Institute of Technology, USA)
"Pathways and Processes of Prokaryotic N-Linked Glycosylation"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amGiulia Bandini (Boston University, USA)
"Glycoproteins with Fucosylated O-Glycans Are Present in a Structure Associated with the Nuclear Membrane of Toxoplasma gondii"
9:50 am - 9:55 amDiscussion
9:55 am - 10:20 amElizabeth Hartland (University of Melbourne, Australia)
"A Surprising Glycosylation Prevents Cell Death During E. coli Infection"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amMalcolm McConville (University of Melbourne, Australia)
"Dissecting Unusual Glycosylation Pathways in Microbial Pathogens"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amItamar Yadid (Migal - Galilee Research Institute, Israel)
"A Lectin Based Screen for the Identification of Genes Relevant to Bacterial Biosynthesis of Glycosphingolipids"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmRita Gerardy-Schahn (Hannover Medical School, Institute for Cellular Chemistry, Germany)
"Linkage Specificity Determinants of Bacterial Capsule Polymerases"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGlycobiology of the Microbiota
Discussion Leader: Rita Gerardy-Schahn (Hannover Medical School, Institute for Cellular Chemistry, Germany)
6:00 pm - 6:25 pmChristine Szymanski (University of Alberta, Canada)
"Interactions Between Campylobacter jejuni and the Gut Microbiome"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmHarry Gilbert (University of Newcastle, United Kingdom)
"Glycan Utilization by the Human Distal Gut Microbiota"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmYen-Lin Huang (University of Zurich, Switzerland)
"Sialic Acid Promotes Overgrowth of Intestinal E. coli and Intestinal Inflammation"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmLars Bode (University of California, San Diego, USA)
"Human Milk Oligosaccharides as Direct and Indirect Primers for the Infant Microbiome"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGlycobiology of Plants, Flies and Worms
Discussion Leader: Michael Tiemeyer (University of Georgia, USA)
9:00 am - 9:25 amHenrik Scheller (Lawrence Berkeley National Laboratory, USA)
"Nucleotide Sugar Transporters in Plants and Their Role in Glycan Biosynthesis"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amEls Van Damme (Ghent University, Belgium)
"Lectin Domains at the Frontiers of Plant Defense"
9:50 am - 9:55 amDiscussion
9:55 am - 10:20 amKelly Ten Hagen (National Institutes of Health, USA)
"Protein O-Glycosylation in Developmentally Regulated Secretion"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amHannes Buelow (Albert Einstein College of Medicine, USA)
"Heparan Sulfate Modification Patterns in Development and Disease"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmJoseph Yost (University of Utah, USA)
"HSPGs in Cardiovascular Development"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAnne Harduin-Lepers (CNRS, France)
"Integrative View of a 2,3-Sialyltransferases (ST3Gal) Molecular and Functional Evolution in Deuterostomes: Significance of Lineage Specific Losses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGlycobiology: A Molecular View
Discussion Leader: Karen Colley (University of Illinois, Chicago, USA)
6:00 pm - 6:25 pmGideon Davies (University of York, United Kingdom)
"Diverse Strategies for the Degradation of Mannosides"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmKelley Moremen (University of Georgia, USA)
"Structural Basis for Substrate Specificity Among N-Glycan (GH47) Processing Alpha-Mannosidases"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmCamilo Perez (ETH Zürich, Switzerland)
"Mechanism of Lipid-Linked Oligosaccharide Flipping by the ABC Exporter PglK"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmKatie Doores (King's College London, United Kingdom)
"HIV Envelope Glycosylation and Broadly Neutralizing Antibody Recognition."
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmChrista Litschko (Institute for Cellular Chemistry, Germany)
"The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyses the Formation of Glycosidic Bonds and the Transfer of GlcNAc-1-Phosphate"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiosynthesis of Carbohydrates; Carbohydrates in Disease
Discussion Leader: John Hanover (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
9:00 am - 9:25 amHans Bakker (Hannover Medical School, Germany)
"From Identification of the C-Mannosyltransferase Gene to Function of C-Mannosylation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSabine Strahl (University of Heidelberg, Germany)
"Protein O-Mannosylation: Cadherins and Beyond"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amHans Wandall (University of Copenhagen, Denmark)
"Molecular Dissection of Glycan Function by Simple Cells and Simplified Tissues"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amTaroh Kinoshita (Osaka University Research Institute for Microbial Disease, Japan)
"Shedding of Cripto-1 by PGAP6, a Membrane-Bound, GPI-Specific Phospholipase A2"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amMichelle Dookwah (University of Georgia, USA)
"Cell-Specific Glycomic and Signaling Alterations Associated with Human Ganglioside Deficiency"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmMichael Pierce (University of Georgia, USA)
"A Unique, Protein-Specific N-Glycan with High Sensitivity and Specificity for Pancreatic Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCarbohydrate-Binding Proteins
Discussion Leader: Anne Imberty (CERMAV-CNRS, Grenoble, France)
6:00 pm - 6:25 pmTakashi Angata (Academia Sinica, Taiwan)
"Siglec-14: From Molecular Evolution to Disease Susceptibility"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmGabriel Rabinovich (Laboratorio de Inmunopatologia, Argentina)
"Integrating Immune and Vascular Signaling Programs Through Galectin-Glycan Interactions"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmFelix Randow (MRC Laboratory of Molecular Biology, United Kingdom)
"Galectins as Danger Receptors for Cellular Damage and Pathogen Invasion"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmBirte Svensson (Technical University of Denmark, Denmark)
"Surface Binding Sites (SBS) in Carbohydrate-Active Enzymes"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmGlycobiology of Biopharmaceuticals and Vaccines
Discussion Leader: Irma Van Die (VU University Medical Center Amsterdam, The Netherlands)
9:00 am - 9:25 amRichard Cummings (Emory University School of Medicine, USA)
"Glycans As Antigens and Modulators of Immunity"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amFrancesco Berti (Novartis Vaccines and Diagnostics, Italy)
"In vitro Synthesized Capsular Polysaccharides: Towards a Novel Strategy for Production of Glycoconjugate Vaccines Against Neisseria meningitidis Infections"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 10:55 amSabina Gerber (GlycoVaxyn AG, Switzerland)
"A Novel Bioconjugate Vaccine to Prevent Staphylococcus aureus Infection"
10:55 am - 11:00 amDiscussion
11:00 am - 11:15 amFabrizio Chiodo (Leiden University Medical Center, The Netherlands)
"On the Dual Antigen/Adjuvant Role of Haemophilus influenzae Synthetic Polysaccharides in Carbohydrate-Based Vaccines"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amKuo-I Lin (Academia Sinica, Taiwan)
"Vaccination with Monoglycosylated Hemagglutinin Induced Cross-Strain Immunity Against Influenza Virus Infections"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amSusanna Fleurkens (ETH Zurich, Switzerland)
"Glycoengineering in Insect Cells to Produce Carbohydrate-Based Vaccines Against Haemonchus contortus"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmIrma Van Die (VU University Medical Center Amsterdam, The Netherlands)
"Immunomodulation by Glycans of the Whipworm Trichuris suis: Implications for Multiple Sclerosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAnalytical Tools and Big Data
Discussion Leader: Nicolle Packer (Macquarie University, Australia)
6:00 pm - 6:25 pmBernard Henrissat (CNRS, France)
"The Power of Glycogenomics (How Carbohydrate-Active Enzymes Link Glycobiology to Genomics)"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmManfred Wuhrer (Vrije University Amsterdam, The Netherlands)
"Mass Spectrometry for Revealing Disease-Associated Glycosylation Changes"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmWilliam York (University of Georgia, USA)
"A Major Challenge of Glycoinformatics: Resolving the Significance of Incomplete Analytical Information"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13GM105060 - 01 from National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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