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Glycobiology
Gordon Research Conference

Glycan Function and Structure from Nucleus to Niche

Dates

March 19-24, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Michael Tiemeyer

Vice Chair:
Rita Gerardy-Schahn

Meeting Description

The Glycobiology Gordon Research Conference is one of the leading meetings in glycoconjugate function and structure. It offers a collegial setting and provides a unique platform to present the newest developments in the field and to discuss the latest findings in this multidisciplinary area of research. Glycoconjugates carry biological information and are ideally suited to mediate interactions at the molecular and cellular level as well as between organisms. Elaborate biosynthetic pathways have evolved to regulate the biosynthesis and degradation of glycoconjugates, emphasizing their biological importance. This meeting marks the 20th iteration of the biennial Glycobiology GRC and will focus on glycan function and structure in a variety of living systems and processes, including human physiology and pathology.

An exceptional and diverse group of international scientists will present at the meeting. The scientific sessions will cover diverse areas of the field, including the role of glycans in cell-cell and cell-microbe interactions, evolutionary pressures that influence glycan diversity, the glycobiology of prokaryotes and parasites, the cellular basis for regulated glycan expression, the glycobiology of neural development and neural function, therapeutic approaches that leverage glycoconjugates, and novel human diseases and disease models. Approximately 30 invited talks and 20 short talks (selected from poster abstracts), along with highly interactive poster sessions, define the core of the Glycobiology GRC. For the third time, a Glycobiology Gordon Research Seminar (GRS) will also be held in advance of the GRC, designed to foster interactions between graduate students, post-docs, and established researchers as mentors.

Related Meeting

This GRC was held in conjunction with the "Glycobiology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Interdisciplinary Glycobiology
Cross-cutting topics from leading glycobiologists.
Discussion Leader: Kelly Ten Hagen (National Institutes of Health, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:15 pmPamela Stanley (Albert Einstein College of Medicine, USA)
"Glycans that Regulate Cell Fate Decisions in Mammals"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmJeffrey Esko (University of California, San Diego, USA)
"The Iron-y of the Lipoprotein Receptor, Syndecan-1"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmMarkus Aebi (ETH Zurich, Switzerland)
"Precisely Heterogeneous - The Biogenesis of N-Linked Protein Glycosylation"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycans in Niche Communities and Innate Immunity
Glycan mediators of cell-cell and cell-biome interactions, innate immune responses, and regulated glycosylation of immune cells and tissues.
Discussion Leaders: Anne Imberty (CERMAV, CNRS, France) and Fikri Avci (Center for Molecular Medicine, University of Georgia, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader: Glycans in Niche Communities
9:05 am - 9:30 amHiutung Chu (California Institute of Technology, USA)
"Gene-Microbiota Interactions Contribute to the Pathogenesis of Inflammatory Bowel Disease"
9:30 am - 9:35 amDiscussion
9:35 am - 10:00 amAlisdair Boraston (University of Victoria, Canada)
"The Destruction of Host Glycoconjugates by Microbial Commensals and Pathogens"
10:00 am - 10:05 amDiscussion
10:05 am - 10:15 amMario Feldman (Washington University School of Medicine, USA)
"PglC, a Short Bacterial Phospho-Glycosyltransferase with Tunable Specificity"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 10:55 amIntroduction by Discussion Leader: Innate Immunity
10:55 am - 11:20 amVictor Nizet (University of California, San Diego, USA)
"Glycan Modulation of Pathogen-Phagocyte Interactions"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amRonald Schnaar (Johns Hopkins School of Medicine, USA)
"Siglec Ligands in Human Airway Inflammation"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmMichal Stanczak (University Hospital Basel, Switzerland)
"Upregulation of Self-Associated Molecular Patterns and Siglec Receptors on T Cells Facilitate Cancer Immune Evasion"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmLubor Borsig (University of Zurich, Switzerland)
"Alteration in Mucin Glycosylation and Bacterial Colonization During Colitis"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Karen Colley (University of Illinois at Chicago, USA) and Nicolle Packer (Macquarie University, Australia)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycosylation and Signaling
Nucleocytoplasmic glycosylation and the role of cell surface signaling receptors in regulating glycan expression.
Discussion Leader: John Hanover (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
7:30 pm - 7:55 pmGerald Hart (Johns Hopkins School of Medicine, USA)
"Nutrient Regulation of Transcription and Signaling by O-GlcNAcylation: A Fundamental Mechanism of Glucose Toxicity in Diabetes"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmKay Grobe (University of Muenster, Germany)
"Extracellular Heparan Sulfate in Hedgehog Morphogen Processing and Function"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmWilliam Sessa (Yale University, USA)
"Cis-Prenyltranferase: From Polyprenols to Human Glycosylation Disorders"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmCasey Daniels (National Institutes of Health, USA)
"ADP-Ribosylation in the Innate Immune Response"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmKevin Chandler (Boston University, USA)
"N-Glycosylation Regulates Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Activation and Signaling"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGlycobiology of HIV, Evolution, and Development
Glycan modulation of HIV virus antigenicity, evolutionary pressures on glycan diversity, and developmental roles for glycan elaboration.
Discussion Leaders: Thierry Hennet (University of Zurich, Switzerland) and Robert Haltiwanger (University of Georgia, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader: HIV Glycobiology
9:05 am - 9:30 amMax Crispin (University of Oxford, United Kingdom)
"The HIV Glycan Shield and Immunogen Design"
9:30 am - 9:35 amDiscussion
9:35 am - 10:00 amGalit Alter (Ragon Institute, Harvard Medical School, USA)
"Antibody Glycosylation as a Key Predictor of Protective Humoral Immunity Against Infection"
10:00 am - 10:05 amDiscussion
10:05 am - 10:15 amGiulia Bandini (Boston University, USA)
"Toxoplasma gondii Has Distinct Nucleocytosolic and Secretory O-Fucosylation Pathways"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 10:55 amIntroduction by Discussion Leader: Evolutionary and Developmental Glycobiology
10:55 am - 11:20 amPascal Gagneux (University of California, San Diego, USA)
"Ecology and Evolution of Glycans"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amHamed Jafar-Nejad (Baylor College of Medicine, USA)
"Regulation of BMP Signaling by Drosophila NGLY1"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmNaazneen Khan (University of California, San Diego, USA)
"New Insights into Host Adaptation of Yersinia pestis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmJoao Rodrigues (Instituto de Medicina Molecular, Portugal)
"Plasmodium Short N-Glycans Are Critical for Parasite Survival and Development"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLeveraging Glycoscience for Developing Therapeutics
Leveraging glycoknowledge to design therapeutics and to understand human disease or disease model pathophysiology.
Discussion Leader: Michael Pierce (University of Georgia, USA)
7:30 pm - 7:55 pmJames Paulson (The Scripps Research Institute, USA)
"Targeting Siglecs to Modulate Immune Cell Responses"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmStephen Withers (University of British Columbia, Canada)
"Novel Pharmacophores for Glycosidase Inhibition"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmThomas Clausen (University of Copenhagen, Denmark)
"Chasing the Structure of Oncofetal Chondroitin Sulfate"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmHeinz Laubli (University Hospital Basel, Switzerland)
"Targeting Sialic Acid-Mediated Interactions to Reverse Cancer-Associated Immune Suppression"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmIrina Alymova (Centers for Disease Control and Prevention, USA)
"Effects of a Novel Inhibitor of N-Linked Glycosylation, NGI-1, on Influenza Immunogenicity"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular and Molecular Pathways for Glycoprotein Trafficking and the Glycobiology of Microbes and Parasites
Molecular and cellular pathways that modulate glycosylation and glycoprotein trafficking as well as glycans produced by microbes, and parasites, and the host glycofactors that modulate pathogenicity.
Discussion Leaders: Richard Steet (University of Georgia, USA) and Richard Cummings (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader: Glycoprotein Trafficking
9:05 am - 9:30 amTadashi Suzuki (RIKEN Global Research Cluster, Japan)
"Toward Curing NGLY1-Deficiency"
9:30 am - 9:35 amDiscussion
9:35 am - 10:00 amHans Wandall (University of Copenhagen, Denmark)
"Galectin Secretion Directed by the Cellular Glycosylation State and Controlled by Autophagy"
10:00 am - 10:05 amDiscussion
10:05 am - 10:15 amYanzhuang Wang (University of Michigan, USA)
"GRASP55 Senses Energy Deprivation Through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 10:55 amIntroduction by Discussion Leader: Microbes and Parasites
10:55 am - 11:20 amMichael A. Ferguson (University of Dundee, United Kingdom)
"Novel Bio-Conversions and Nucleotide Sugar Transport Mechanisms in Trypanosomatid Parasites"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amChristine Szymanski (Complex Carbohydrate Research Center, University of Georgia, USA)
"Multiple Roles for Campylobacter Glycoconjugates"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmAitor Casas-Sanchez (Liverpool School of Tropical Medicine, United Kingdom)
"Understanding the Glycocalyx of the Infectious Trypanosoma brucei Metacyclic Forms"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmMarta Cova (ISGlobal, Spain)
"Biochemical and Evolutionary Characterization of the GNA Gene Family in Apicomplexa"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmStructural Biology of Glycogene Products
Motif specific glycosylation and protein structural determination of important glycoenzymes and complexes.
Discussion Leader: Karen Colley (University of Illinois at Chicago, USA)
7:30 pm - 7:55 pmMario Schubert (University of Salzburg, Austria)
"Structural Insights into Sulfation-Dependent Self-Glycan Recognition by the Human Immune-Inhibitory Receptor Siglec-8"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmJochen Zimmer (University of Virginia School of Medicine, USA)
"Commonalities and Differences Among Membrane-Embedded Processive Glycosyltransferases"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmKelley Moremen (University of Georgia, USA)
"Structural Basis of GlcNAc Transferase Substrate Specificity"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMaja Napiorkowska (ETH Zurich, Switzerland)
"Structural Studies of Bacterial Oligosaccharyltransferase PglB"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmChristopher West (University of Georgia, USA)
"Glycosylation Associated with O2-Sensing Modulates the F-Box Combining Site in Dictyostelium Skp1"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOmics, Informatics, and the Pathobiochemistry of Glycosylation Diseases
Advances in omics, integrated omics, bioinformatics for glycobiology and the impact of altered glycosylation for human disorders of glycosylation.
Discussion Leaders: Nicolle Packer (Macquarie University, Australia) and Linda Baum (University of California, Los Angeles, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader: Omics and Informatics
9:05 am - 9:30 amAnne Dell (Imperial College London, United Kingdom)
"High Sensitivity Glycomics: Windows to Glycan Function"
9:30 am - 9:35 amDiscussion
9:35 am - 10:00 amMichael Snyder (Stanford University, USA)
"Glycomics, Personal Profiling and Prediabetes"
10:00 am - 10:05 amDiscussion
10:05 am - 10:15 amKiyoko Aoki-Kinoshita (Soka University, Japan)
"Analyzing Glycans and Glycogenes with Web Resources: RINGS, FlyGlycoDB and GlyTouCan"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 10:55 amIntroduction by Discussion Leader: Glycosylation Diseases
10:55 am - 11:20 amLance Wells (University of Georgia, USA)
"Whoa Man: Regulating Functional O-Mannosylation"
11:20 am - 11:25 amDiscussion
11:25 am - 11:50 amNancy Dahms (Medical College of Wisconsin, USA)
"Glycosphingolipid Expression in a New Animal Model of Fabry Disease"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmBernadette Holdener (Stony Brook University, USA)
"Deletion of B3GLCT Disrupts Craniofacial, Skeletal, and Cardiac Development in Mice"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmElsenoor Klaver (University of Georgia, USA)
"Insights into Neuromuscular Pathogenesis of CDGs Using a Novel PMM2 Zebrafish Mutant"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycobiology of Neural Function and Disease
Glycan functions in neural development, neurophysiology, and neural disease.
Discussion Leader: Rita Gerardy-Schahn (Institute for Cellular Chemistry, Hannover Medical School, Germany)
7:30 pm - 7:55 pmMaria Lehtinen (Boston Children's Hospital, USA)
"Cerebrospinal Fluid-Based Signaling in the Mammalian Brain"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmHerbert Hildebrandt (Hannover Medical School, Germany)
"The Role of Polysialic Acid in Myelin Repair"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmVlad Panin (Texas A&M University, USA)
"Mechanisms Regulating Sialylation and Its Effect on Neural Transmission in Drosophila"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMariska Davids (National Institutes of Health, USA)
"GPI-Anchor Synthesis Deficiency Caused by Homozygous Splice-Variants in Human ARV1"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmStephanie Olivier-Van Stichelen (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Nutrient-Driven O-GlcNAc Cycling Impacts Neurodevelopmental Timing and Metabolism"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by DE026693-01 from the National Institute of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Institute of Allergy and Infectious Diseases. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Heart, Lung, and Blood Institute. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Center for Advancing Translational Sciences, the National Institute of Child Health and Human Development, the National Cancer Institute, and the National Eye Institute.
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