Applications for this meeting must be submitted by January 11, 2015. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
The Mammalian DNA Repair Gordon Research Conference will be held in conjunction with the Mammalian DNA Repair Gordon Research Seminar
. Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Please refer to the Mammalian DNA Repair GRS web page for more information.
The Mammalian DNA Repair Gordon Research Conference has met biannually since 1986 and covers recent highlights in research from DNA repair and related areas. The conference is known for its friendly and informal atmosphere and provides ample opportunities for informal discussions among students, postdocs, PIs and researchers from industry. DNA repair processes are essential for preventing carcinogenesis in humans, as evidenced by a large number of cancer-prone hereditary disorders resulting form defects in DNA repair genes. Conversely, DNA repair proteins are increasingly sought after drug targets in antitumor therapy, as evidenced by the recent success of PARP inhibitors. The 2015 conference will feature recent highlights from all areas of DNA repair and a number of cutting edge topics, such as single molecule and structural approaches to study damage recognition, the emerging area of ribonucleotide repair, non-coding RNAs in the DNA damage response, the connection of DNA repair defects with inflammation and infectious disease or the role of DNA repair enzymes in epigenetic regulation. There will also be a session of how DNA repair can be targeted for cancer therapy.
Presentation of unpublished results will be strongly emphasized in instructions to all speakers, and interactive discussions involving all conferees will be actively encouraged. The conference will involve a number of development opportunities for students, postdocs and early career scientists, including the possibility to submit abstracts for short talks, activities to foster social interaction between PIs and junior researchers, and the possibility to attend the associated Gordon Research Seminar. This conference has frequently been over-subscribed in the past, so early application with submission of abstracts is strongly encouraged to aid in selection of conference participants and short platform talks. We look forward to your active participation at the 2015 Mammalian DNA Repair GRC in Ventura!
A list of preliminary session topics and speakers is displayed below (discussion leaders are noted in italics). The detailed program is currently being developed by the Conference Chair and will be available by October 8, 2014. Please check back for updates.
Keynote Session: DNA Repair and Genome Dynamics
(Orlando Scharer / Simon Boulton / Tom Mistelli)
Cellular Responses to Endogenously Generated DNA Damage
(Leona Samson / Bruce Demple / Chuan He / Thomas Kunkel / Samuel Wilson)
Damage Recognition and Ubiquitin Signaling in Nucleotide Excision Repair
(Bennett Van Houten / Jung-Hyun Min / Kaoru Sugasawa / Wim Vermeulen)
Diverse Mechanisms of Double Strand Break Repair
(Tanya Paull / Stephen Kowalczykowski / John Tainer / Stephen West / Claire Wyman)
Exploiting Genome Instability for Anticancer Therapy
(Mark O'Connor / John Pascal / Yves Pommier)
DNA Damage Signaling at Double Stand Breaks and Replication Forks
(Karlene Cimprich / Dipanjan Chowdhury / David Cortez / Daniel Durocher / Niels Mailand)
Disease Phenotypes Resulting from DNA Repair Defects
(Bevin Engelward / Winfried Edelmann / Jan Hoeijmakers / Laura Niedernhofer)
Responding to Obstacles at Replication Forks
(Roger Woodgate / Dana Branzei / Fumio Hanaoka / Josef Jiricny / Antoine Van Oijen)
Fanconi Anemia-Dependent and -Independent Repair of DNA Crosslinks
(Johannes Walter / Alan D'Andrea / Peter McHugh / John Rouse)