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Conference Program
 
Mammalian DNA Repair
Controlling Traffic on the Streets and at the Crossroads of DNA Repair Pathways
February 8-13, 2015
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Orlando D. Scharer

Vice Chair:
Wei Yang

Related Meeting Information
The Mammalian DNA Repair Gordon Research Conference was held in conjunction with the Mammalian DNA Repair Gordon Research Seminar. Please refer to the Mammalian DNA Repair GRS web page for more information.

The Mammalian DNA Repair Gordon Research Conference has met biannually since 1986 and covers recent highlights in research from DNA repair and related areas. The conference is known for its friendly and informal atmosphere and provides ample opportunities for informal discussions among students, postdocs, PIs and researchers from industry. DNA repair processes are essential for preventing carcinogenesis in humans, as evidenced by a large number of cancer-prone hereditary disorders resulting form defects in DNA repair genes. Conversely, DNA repair proteins are increasingly sought after drug targets in antitumor therapy, as evidenced by the recent success of PARP inhibitors. The 2015 conference will feature recent highlights from all areas of DNA repair and a number of cutting edge topics, such as single molecule and structural approaches to study damage recognition, the emerging area of ribonucleotide repair, non-coding RNAs in the DNA damage response, the connection of DNA repair defects with inflammation and infectious disease or the role of DNA repair enzymes in epigenetic regulation. There will also be a session of how DNA repair can be targeted for cancer therapy.

Presentation of unpublished results will be strongly emphasized in instructions to all speakers, and interactive discussions involving all conferees will be actively encouraged. The conference will involve a number of development opportunities for students, postdocs and early career scientists, including the possibility to submit abstracts for short talks, activities to foster social interaction between PIs and junior researchers, and the possibility to attend the associated Gordon Research Seminar. This conference has frequently been over-subscribed in the past, so early application with submission of abstracts is strongly encouraged to aid in selection of conference participants and short platform talks. We look forward to your active participation at the 2015 Mammalian DNA Repair GRC in Ventura!


Contributors

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: DNA Repair and Genome Dynamics
Discussion Leader: Orlando Scharer (Stony Brook University)
7:40 pm - 8:20 pmKeynote: Simon Boulton (Cancer Research, United Kingdom)
"Genome Stability and the Control of Recombination"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmKeynote: Mark O'Connor (AstraZeneca, United Kingdom)
"Lynparza (Olaparib): The Story of the Science and Development Behind the First Approved Medicine Targeting the DNA Damage Response"
9:15 pm - 9:30 pmDiscussion
Monday
8:30 amGroup Photo
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Responses to Endogenously Generated DNA Damage
Discussion Leader: Bruce Demple (Stony Brook University School of Medicine)
9:00 am - 9:20 amThomas Kunkel (NIEHS, NIH)
"Using Ribonucleotides to Track DNA Polymerization In Vivo"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBruce Demple (Stony Brook University School of Medicine)
"Preventing Genomic Erosion Through Base Excision Repair"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amZachary Nagel (Massachusetts Institute of Technology)
"Using High-Throughput Assays to Measure Inter-Individual Differences in DNA Repair Capacity and to Understand Mechanisms of Cancer Therapy Resistance"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amPatricia Opresko (University of Pittsburgh)
"Telomeres Are Proficient for Removal of UV Photoproducts by Nucleotide Excision Repair"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amChuan He (University of Chicago)
"Studies of the AlkB Family Demethylases"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amLi Lan (University of Pittsburgh Cancer Institute)
"A Novel Method for Site-Specific Induction of Oxidative DNA Damage Reveals Differences in Recruitment of Repair Proteins to Heterochromatin and Euchromatin"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSamuel Wilson (NIEHS, NIH)
"Pathway Coordination in BER of Oxidative Lesions"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDamage Recognition and Ubiquitin Signaling in Nucleotide Excision Repair
Discussion Leader: Bennett Van Houten (University of Pittsburgh)
7:30 pm - 7:50 pmBennett Van Houten (University of Pittsburgh)
"NER Damage Recognition: 'Kicking the Tires' During Conformational Proofreading"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJung-Hyun Min (University of Illinois, Chicago)
"Twist-Open Mechanism of DNA Damage Recognition by Rad4/XPC Nucleotide Excision Repair Complex"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKaoru Sugasawa (Kobe University, Japan)
"In Vivo Regulation of Mammalian Nucleotide Excision Repair"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmWim Vermeulen (Erasmus Medical Center, The Netherlands)
"Ubiquitin-Mediated Control of NER Initiation"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiverse Mechanisms of Double Strand Break Repair
Discussion Leader: Tanya Paull (University of Texas, Austin)
9:00 am - 9:20 amStephen Kowalczykowski (University of California, Davis)
"Roles of BRCA2 and RAD51 Paralogs in Recombinational DNA Repair"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTanya Paull (University of Texas, Austin)
"Regulation of DNA Double-Strand Break Repair"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPetr Cejka (Univeristy of Zurich, Switzerland)
"Human MMS22-TONSL Complex Promotes Homologous Recombination"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amJoseph Loparo (Harvard Medical School)
"Bridging the Gap: Single-Molecule Studies of Non-Homologous End-Joining"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amXiaohua Wu (The Scripps Research Institute)
"CtIP and Mre11 Prevent Genome Instability at Common Fragile Sites and Inverted Repeats"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amClaire Wyman (Erasmus University Medical Center, The Netherlands)
"Dynamic Nanomachines of DNA Break Repair"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmStephen West (London Research Institute, United Kingdom)
"Regulation and Mechanisms of Recombinational Repair"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExploiting Genome Instability for Anticancer Therapy
Discussion Leader: Mark O'Connor (AstraZeneca, United Kingdom)
7:30 pm - 7:50 pmYves Pommier (National Cancer Institute)
"Topoisomerase-Induced DNA Damage and Tyrosyl-DNA-Phosphodiesterases-Mediated DNA Repair in the Nuclear and Mitochondrial Genomes of Cancer Cells and Neurons"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmKyungjae Myung (IBS, South Korea)
"Identification of a Potential Chemotherapeutic Agent to Treat Mismatch Repair Deficient Tumors"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmSharon Cantor (University of Massachusetts Medical School)
"A Novel Mechanism of Therapy Resistance in BRCA2-Mutant Cells"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJohn Pascal (Thomas Jefferson University)
"Structural Biology of DNA-Damage Dependent PARPs"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmKeith Wilcoxen (TESARO Inc.)
"The Challenges of Precision Medicine in the Development of PARP Inhibitors"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmXavier Jacq (MISSION Therapeutics, United Kingdom)
"Development of Selective DUB Inhibitors Targeting DDR Deficient Tumours"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage Signaling at Double Stand Breaks and Replication Forks
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine)
9:00 am - 9:20 amJohn Tainer (Lawrence Berkeley National Laboratory)
"Controlling MRE11-RAD50: DNA Conformations and Pathway Choice at dsDNA Breaks"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKarlene Cimprich (Stanford University School of Medicine)
"Mechanisms for Maintaining Genome Stability"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDipanjan Chowdhury (Dana Farber Cancer Institute)
"Non-Coding RNAs in the DNA Damage Response"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amAlessandro Sartori (Institute of Molecular Cancer Research, Switzerland)
"CtIP Ubiquitination: New Insights into the Regulation of DNA-End Resection"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSumita Bhaduri-McIntosh (Stony Brook University)
"STAT3 Interrupts ATR-Chk1 Signaling to Allow Oncovirus-Mediated Cell Proliferation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amNiels Mailand (University of Copenhagen, Denmark)
"New Players in the Ubiquitin-Dependent Signaling Response to DNA Damage"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmDaniel Durocher (Lunenfeld-Tananbaum Research Institute, Canada)
"Cell Cycle Regulation of DNA Double-Strand Break Repair"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDisease Phenotypes Resulting from DNA Repair Defects
Discussion Leader: Laura Niedernhofer (The Scripps Research Institute)
7:30 pm - 7:50 pmLaura Niedernhofer (The Scripps Research Institute)
"Unanticipated Consequences of Nuclear DNA Damage"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmWinfried Edelmann (Albert Einstein College of Medicine)
"Cancer Stem Cell Niche Structures Accumulate in Response to mTOR Inhibition in MMR-Deficient Intestinal Tumors"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRichard Wood (University of Texas MD Anderson Cancer Center)
"DNA Damage Sensitivity Associated with DNA Polymerase Defects"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJan Hoeijmakers (Erasmus University, The Netherlands)
"The Overwhelming Impact of DNA Damage on Aging and Prospects for Intervention"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmResponding to Obstacles at Replication Forks
Discussion Leader: Roger Woodgate (National Institutes of Health)
9:00 am - 9:20 amDavid Cortez (Vanderbilt University Medical Center)
"Using iPOND to Understand the Replication Stress Response"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAlan D'Andrea (Dana-Farber Cancer Institute)
"Novel Regulators of the Fanconi Anemia/BRCA Pathway"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amAgnel Sfeir (New York University Langone Medical Center)
"Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amEvert-Jan Uringa (University Medical Center Groningen, The Netherlands)
"Single-Molecule Imaging of RTEL1 in Embryonic Stem Cells"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amRoger Woodgate (National Institutes of Health)
"Posttranslational Regulation of DNA Polymerase Iota"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amZvi Livneh (Weizmann Institute of Science, Israel)
"Novel Regulators of DNA Damage Tolerance by Translesion DNA Synthesis: The Leukemia Connection"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmFumio Hanaoka (Gakushuin University, Japan)
"Functional Roles of TLS Polymerases in Mouse Skin upon UV Irradiation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFanconi Anemia-Dependent and -Independent Repair of DNA Crosslinks
Discussion Leader: Johannes Walter (Harvard Medical School)
7:30 pm - 7:50 pmJohannes Walter (Harvard Medical School)
"Mechanisms of Vertebrate Cross-Link Repair"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPierre-Henri Gaillard (Cancer Research Center of Marseille CNRS, France)
"The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmLei Li (M. D. Anderson Cancer Center)
"UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPeter McHugh (University of Oxford, United Kingdom)
"The Nucleases of Replication-Dependent and -Independent ICL Repair"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJohn Rouse (University of Dundee, United Kingdom)
"Dissecting the Repair of Interstrand DNA Crosslinks"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA192553-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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