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Molecular Membrane Biology
Gordon Research Conference

Regulation of Ways of Communication – From Molecules to Organisms

Dates

July 16-21, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chair:
Anne Spang

Vice Chair:
Ramanujan S. Hegde

Application Deadline

Applications for this meeting must be submitted by June 18, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Conference on Molecular Membrane Biology covers recent advances in membrane traffic and organelle biology with a focus on the regulation of trafficking pathways and the communication between organelles at contact sites. The topics that will be covered include protein translocation, exo- and endocytosis, unconventional secretion, autophagy, lipid biology, organelle biogenesis and contact sites. These will be put in the context of organismal development as well as health and disease, and aging. One session is reserved to breaking discoveries in these areas. The coverage of such a broad topic mandates multidisciplinary approaches combining classical cell biology and biochemistry, next generation genetics, super-resolution microscopy, structural biology and advanced biophysical methods.

In addition to invited speakers, 15 short talks will be selected based on submitted abstracts, and posters will be presented throughout the meeting covering the latest developments in the field and promoting intense discussions among all Conference attendees. Applicants are encouraged to submit a brief abstract describing their current studies and to indicate whether they wish to present a poster or to be considered for a talk. For full consideration, applicants interested in presenting a short talk should submit their application by April 15, 2017.

Prior to and in association with the Gordon Research Conference, there will be the Gordon Research Seminar (GRS) on Molecular Membrane Biology for students and postdoctoral researchers. In this forum, younger researchers will have the opportunity to present their work in talks and posters and to built collaborations and informal networks with their peers prior to the arrival of senior investigators. Interested trainees are encouraged to view the website and consider attending.

Related Meeting

This GRC will be held in conjunction with the "Molecular Membrane Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Communication Between Organelles and with the Outside
Discussion Leader: Anne Spang (Biozentrum, University of Basel, Switzerland)
7:40 pm - 8:20 pmJodi Nunnari (University of California, Davis, USA)
"Emerging Network of Membrane Contact Sites"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmRandy Schekman (University of California, Berkeley, USA)
"RNA Sorting and Secretion in Exosomes"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Biosynthesis and the Early Secretory Pathway
Discussion Leader: Akihiko Nakano (Graduate School of Science, University of Tokyo, Japan)
9:00 am - 9:20 amJochen Zimmer (University of Virginia School of Medicine, USA)
"ABC Transporters Implicated in Biopolymer Translocation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTom Rapoport (Harvard Medical School / Howard Hughes Medical Institute, USA)
"Mechanism of ER-Associated Protein Degradation (ERAD)"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amUlrike Kutay (Institute of Biochemistry, ETH Zurich, Switzerland)
"Targeting of Membrane Proteins from the ER to the Inner Nuclear Membrane"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amCatherine Rabouille (Hubrecht Institute, The Netherlands)
"Sec16: A Stress Response Protein"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amFranck Perez (Institut Curie, UMR144, CNRS, France)
"Exploring and Exploiting Intracellular Transport of Mammalian Cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of Golgi Function and Transport
Discussion Leader: Jennifer Lippincott-Schwartz (National Institutes of Health, USA)
7:30 pm - 7:50 pmSean Munro (MRC Laboratory of Molecular Biology, United Kingdom)
"Golgins and Tethering of Vesicles at the Golgi Apparatus"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBenjamin Glick (University of Chicago, USA)
"Kinetic Mapping of Secretory and Endocytic Traffic in Yeast"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmFrederick Hughson (Princeton University, USA)
"Know When to Hold ‘Em, Know When to Fold ‘Em: Chaperoning SNARE Assembly to Control Membrane Fusion"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRegulation of Exo- and Endocytosis
Discussion Leader: Francis Barr (University of Oxford, United Kingdom)
9:00 am - 9:20 amAxel Brunger (Stanford University, USA)
"Molecular Mechanisms of Synaptic Vesicle Priming"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amIan Macara (Vanderbilt University Medical Center, USA)
"Regulation of the Exocyst by Polarity Proteins"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amChristian Ungermann (University of Osnabrueck, Germany)
"Reconstitution of Endosomal Rab Delivery and Activation"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amFernando Martin-Belmonte (Spanish National Research Council (CSIC), Spain)
"Epithelial-Stromal Crosstalk in Tube Development"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRosa Puertollano-Moro (National Institutes of Health, USA)
"Emerging New Roles of Lysosomes in Cellular Homeostasis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCommunication in Disease, Infection and Immune Response
Discussion Leader: Chris Fromme (Weill Institute for Cell and Molecular Biology, USA)
7:30 pm - 7:50 pmThijn Brummelkamp (Netherlands Cancer Institute, The Netherlands)
"Haploid Genetic Screens to Study Pathogen Entry"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGillian Griffiths (Cambridge Institute for Medical Research, University of Cambridge, United Kingdom)
"Fine-Tuning Lysosomal Secretion"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPaul Lehner (University of Cambridge, United Kingdom)
"Forward Genetic Screens to Identify Novel Ubiquitin E3 Ligases in the Secretory Pathway"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlternative Ways of Communication
Discussion Leader: Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:20 amScott Emr (Weill Institute for Cell and Molecular Biology, Cornell University, USA)
"ESCRTs and Ubiquitin Function in Lysosomal Membrane Protein Turnover and Quality Control"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNatalie Strynadka (University of British Columbia, Canada)
"Structure-Based Analysis of the Type III Secretion System from Pathogenic Bacteria"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amClotilde Thery (INSERM U932, Institut Curie, France)
"Molecular Mechanisms of Biogenesis and Secretion of Exosomes and Other Extracellular Vesicles"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amChiara Zurzolo (Institut Pasteur, France)
"Differential Identity of Tunneling Nanotube and Filopodia and Revealed by the Opposite Functions of Actin Regulatory Complexes and Ultrastructural Analysis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKatharina Gaus (University of New South Wales, Australia)
"T Cell Receptor Clustering – A Mechanism of Signal Transduction"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRegulation of Transport by Lipids
Discussion Leader: Julie Brill (The Hospital for Sick Children, Canada)
7:30 pm - 7:50 pmTamas Balla (National Institute of Child Health and Human Development, NIH, USA)
"Phosphatidylinositol 4-Phosphate Gradients Shape the Lipid Landscape of Eukaryotic Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmElina Ikonen (University of Helsinki, Finland)
"Lipid Trafficking and Storage in the ER"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSuzanne Pfeffer (Stanford University School of Medicine, USA)
"Cholesterol Regulation of Lysosomes"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Degradation Pathways and Signalling
Discussion Leader: Maya Schuldiner (Weizmann Institute of Science, Israel)
9:00 am - 9:20 amDaniel Gottschling (Calico Life Sciences, LLC, USA)
"Lipid Droplet Accumulation in Old Cells: How Aging Affects Metabolism"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBeth Levine (University of Texas Southwestern Medical Center, USA)
"Crucial Role of an Inner Mitochondrial Membrane Receptor in Mitophagy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMichael Rape (University of California, Berkeley, USA)
"The Ubiquitin Code Meets Trafficking"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSharon Tooze (The Francis Crick Institute, United Kingdom)
"Trafficking to the Forming Autophagosome"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amNektarios Tavernarakis (IMBB, Foundation for Research and Technology - Hellas (FORTH), Greece)
"Regulation and Roles of Autophagy in the Mammalian Brain"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Frontiers in Molecular Membrane Biology
Discussion Leader: Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:50 pmRick Horwitz (Allen Institute for Cell Science, USA)
"Multi-Scale Spatial Temporal Cell Biology: A Next Step in the Post Genomic Era"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTomas Kirchhausen (Harvard Medical School, USA)
"Cellular Imaging from Molecules to Organisms"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLate-Breaking Topic
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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