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Phagocytes
Gordon Research Conference

The Yin and Yang of Phagocytes: Regulators of Human Health and Disease

Dates

June 11-16, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chair:
Dianne Cox

Vice Chair:
John H. Brumell

Application Deadline

Applications for this meeting must be submitted by May 14, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Phagocytes, including neutrophils, monocyte/macrophages and dendritic cells, are defined by their ability to ingest other cells or particles. These cells play a central role in innate and adaptive immunity. However, it is now apparent that phagocytes are also critical for maintaining tissue homeostasis, and when thrown out of balance their activities can cause pathological changes that contribute to some of the most prevalent diseases seen globally, including chronic inflammatory diseases such as atherosclerosis and diabetes. Reflecting this, the theme of the 2017 Phagocytes GRC is "The Yin and Yang of Phagocytes: Regulators of Human Health and Disease" and it will be a forum for in depth discussions of the most recent discoveries in phagocyte biology. The meeting will highlight the latest advances in our understanding of inflammation and its resolution, host-pathogen interactions with insight into the mechanisms of infectious disease, elucidating critical underlying mechanisms of phagocyte function in obesity, HIV mediated neuropathies and in cancer. The translational value and the development of new therapies for phagocyte-related diseases will also be discussed. The conference draws from a world-wide group of scientists with diverse backgrounds in cell biology, molecular genetics, microbiology, immunology, bioengineering, and clinical medicine and has been an important venue for disseminating information and facilitating communication between investigators studying different facets of phagocyte function. The program includes sessions, chaired by discussion leaders who are experts in the field, where speakers will present their latest and most exciting unpublished findings. As participation of junior scientists is a key goal of the meeting, the conference will also include ~100 posters, and additional speakers will be chosen from among the submitted abstracts.

To further promote the participation and professional development of students and postdoctoral fellows, the conference will preceded by a Gordon Graduate Research Seminar (GRS).

Related Meeting

This GRC will be held in conjunction with the "Phagocytes" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Balancing Inflammation
Discussion Leader: Steven Greenberg (Celgene, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:10 pmIntroduction by Discussion Leader
8:10 pm - 9:10 pmAnna Huttenlocher (University of Wisconsin-Madison, USA)
"Imaging inflammation and Its Resolution"
9:10 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHost-Pathogen Interactions
Discussion Leader: Michelle Lennartz (Albany Medical College, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amLee-Ann Allen (University of Iowa, USA)
"Neutrophil Plasticity in Helicobacter pylori Infection"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amJoan Berman (Albert Einstein College of Medicine, USA)
"The Devil of HIV Neuropathogenesis: The Macrophage"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amGroup Photo / Coffee Break
10:55 am - 11:15 amJennifer Philips (Washington University School of Medicine, USA)
"Mycobacterium tuberculosis Inhibits the NADPH Oxidase and LC3-Associated Phagocytosis"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amLarry Schlesinger (Ohio State University, USA)
"The Lipid-Filled Alveolar Macrophage and Tuberculosis"
11:50 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Michelle Lennartz (Albany Medical College, USA) and Alison Criss (University of Virginia, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInflammation and Its Resolution
Discussion Leader: Mary Dinauer (Washington University School of Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmJulian G. Cambronero (Boonshoft School of Medicine, Wright State University, USA)
"Macrophage Polarity Switch by PLD Explains the Mechanism of Resolution of Inflammation for Novel Resolvins"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmDaniel Irimia (Harvard Medical School, USA)
"Neutrophil Swarming - Start and Stop Signals"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Invasion
Discussion Leader: Daniel Irimia (Harvard Medical School, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amAttila Mocsai (Semmelweis University, Hungary)
"Neutrophils and Neutrophil Signaling in Inflammatory Disease Models"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amDaniel Hammer (University of Pennsylvania, USA)
"The Forces and Mechanisms of Phagocyte Migration"
10:10 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk Selected from Poster Abstracts
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amStefan Linder (University Medical Center Hamburg-Eppendorf, Germany)
"Actomyosin Contractility and Mechanosensing at Macrophage Podosomes"
11:35 am - 11:45 amDiscussion
11:45 am - 12:10 pmIsabelle Maridonneau-Parini (University of Toulouse, France)
"Macrophage 3D Mesenchymal Migration Requires Mechanosensory Podosomes"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Migration
Discussion Leader: John Brumell (Hospital for Sick Children, Canada)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmCarole Parent (National Cancer Institute, NIH, USA)
"Exosomes as Key Regulators of Neutrophil Signal Relay During Chemotaxis"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmTim Laemmermann (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Neutrophil Swarming at Sites of Inflammation, Infection and Anaphylaxis"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhagocytosis, Macropinocytosis and Exocytosis
Discussion Leader: Joel Swanson (University of Michigan Medical School, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amRobert Kay (MRC Laboratory of Molecular Biology, United Kingdom)
"What Our Cousin Tells Us About Macropinocytosis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amNobukazu Araki (Kagawa University, Japan)
"Control of Macropinosome and Phagosome Formation by Rac1 ON-OFF Switching both in Space and Time"
10:10 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk Selected from Poster Abstracts
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amSergio Catz (The Scripps Research Institute, USA)
"Trafficking of Neutrophil Vesicles: From Mechanism to Translation"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmWill Wood (University of Bristol, United Kingdom)
"Detecting Death and Damage: Understanding Macrophage Migration in Drosophila"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSpecialized Phagocytes
Discussion Leader: Lee-Ann Allen (University of Iowa, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmGustavo Menezes (Federal University of Minas Gerais, Brazil)
"Functional and Spatial Repopulation of Liver Phagocytes During Inflammation"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmClaudia Jakubzick (National Jewish Medical Research Center, USA)
"Double-Edged Sword of Mononuclear Phagocytes in Host Defense and Transplantation"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhagocytes and Human Diseases
Discussion Leader: Anna Huttenlocher (University of Wisconsin-Madison, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJohn Condeelis (Albert Einstein College of Medicine, USA)
"Identification and Inhibition of Specialized Subpopulations of Macrophages Involved in Cancer Metastasis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amFiona Pixley (University of Western Australia, Australia)
"Src Family Kinases in Macrophage Migration in Tumor Spheroids"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amShort Talk Selected from Poster Abstracts
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amStephanie Cherqui (University of California, San Diego, USA)
"Role of Phagocytic Cells in Tissue Repair: Model of Lysosomal and Mitochondrial Genetic Disorders"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmAnthony Ferrante (Columbia University, USA)
"Macrophage Lipid Uptake and Metabolic Health"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMoving Phagocyte Biology from Academic to Industrial Settings
Discussion Leader: Samuel Silverstein (Columbia University Medical Center, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:05 pmSteven Greenberg (Celgene, USA)
"Academia and Industry: Different Oculars, Same Objectives"
6:05 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmMeera Ramanujam (Boehringer Ingelheim Pharmaceuticals, USA)
"Understanding Phagocyte Biology: At the Cross Roads of Academic and Industry Research"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmShort Talk Selected from Poster Abstracts
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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