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Proteins
Gordon Research Conference

Exploring the Role of Proteins as Cellular Organizers by Combining Experiment and Theory

Dates

June 18-23, 2017

Location

Holderness School
Holderness, NH Site Information

Organizers

Chairs:
Catherine A. Royer & Vijay S. Pande

Vice Chairs:
Charles L. Brooks & Elizabeth M. Meiering

Application Deadline

Applications for this meeting must be submitted by May 21, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Proteins Gordon Research Conference has been conceived with two underlying leitmotifs. The first is to highlight proteins as cellular organizers, while the second and equally central theme of the meeting is the interplay between experiment and theory and modeling in modern protein research. Recent major advances in electron and optical microscopy have revealed amazing structural and spatial organization at the level of protein complexes and protein interactions. These advances will be featured by Andre Hoelz of CalTech who will describe the structure of the nuclear pore complex in the opening Keynote address. Our closing Keynote speaker, Carol Post of Purdue University, will address a combined computational and experimental approach to understanding the regulation of a tyrosine kinase. Several sessions will follow up on the theme of proteins as cellular organizers. Session 3 will address new super-resolution imaging of nuclear organization, while Session 4 will speak to the dynamic aspects of proteins as organizers in vesicle sorting and membrane remodeling. Two other sessions, one on the role of intrinsically disordered proteins and the other on protein biogenesis and interactions in vivo will weave in this leitmotif, as well. Given the ever increasing level of integration of experimental and theoretical approaches in protein science, both theory and experiment have been included in each session. In several cases, individual invited speakers will address both experimental and computational aspects of protein research. In other sessions, a combination of talks, some theoretical and others experimental, will address similar topics. Of the 24 invited speakers, we have worked to achieve a near complete balance between theoretical and experimental protein science. The topics for each session correspond to very exciting areas of protein research, in which major advances are currently being achieved. We believe that the combination of these crucial topics and combined approaches, with outstanding scientists who will speak to their work in these areas will make for a very stimulating conference.

Related Meeting

This GRC will be held in conjunction with the "Proteins" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Structure of the Nuclear Pore Complex
Discussion Leader: Catherine Royer (Rensselaer Polytechnic Institute, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:50 pmAndre Hoelze (California Institute of Technology, USA)
"Structure of the Nuclear Pore Complex"
8:50 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmShape-Shifters – Functional Mechanisms of Intrinsically Disordered Proteins
Discussion Leader: Julie Forman-Kay (Hospital for Sick Children, Canada)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMartin Blackledge (Institute for Structural Biology, CNRS, France)
"NMR Studies of the Role of Protein Dynamics in Molecular Recognition - From Fundamental Biophysics to Biological Function"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amShort Talk Selected from Poster Abstracts
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amJoan-Emma Shea (University of California, Santa Barbara, USA)
"Regulation and Aggregation of Intrinsically Disordered Proteins"
10:25 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amJane Dyson (The Scripps Research Institute, USA)
"Interaction Champions: Intrinsically Disordered Viral Proteins"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmRohit Pappu (Washington University in St. Louis, USA)
"Regulation of Protein Function Through Intrinsically Disordered Regions"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHigh Resolution Visualization of Nuclear Organization
Discussion Leader: Jacqueline Cherfils (ENS Cachan, CNRS, France)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmMarcelo Nollmann (Centre de Biochimie Structurale (CBS), CNRS, France)
"Chromosome Structure and Remodelling at Super-Resolution"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmShort Talk Selected from Poster Abstracts
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmElizabeth Villa (University of California, San Diego, USA)
"Opening Windows into the Nucleus: Bringing Structure to Cellular Biophysics"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Protein Functions by Design or Evolution
Discussion Leader: Joan-Emma Shea (University of California, Santa Barbara, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBrian Kuhlman (University of North Carolina at Chapel Hill, USA)
"Computer-Based Design of Protein Interfaces and Switches"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amShort Talk Selected from Poster Abstracts
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amTanja Kortemme (University of California, San Francisco, USA)
"Reshaping and Reprogramming Proteins for New Functions"
10:25 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amLynne Regan (Yale University, USA)
"Novel Supra-Molecular Structures and Materials from Proteins"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmMichael Harms (University of Oregon, USA)
"'Marty, You're Not Thinking Fourth Dimensionally!', High-Order Epistasis in Protein Evolution"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVesicle Sorting and Membrane Remodeling
Discussion Leader: Lila Gierasch (University of Massachusetts Amherst, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJacqueline Cherfils (ENS Cachan, CNRS, France)
"Allosteric Regulation of Small GTPases at the Membrane-Cytosol Interface"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmShort Talk Selected from Poster Abstracts
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmGregory Voth (University of Chicago, USA)
"Membrane Remodeling by Proteins: Insights and Surprises from Multiscale Computer Simulation"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms Underlying Protein Dynamics and Allostery
Discussion Leader: K.C. Huang (Stanford University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBryan Roth (University of North Carolina at Chapel Hill, USA)
"New Insights into the Role of Allosteric Sodium in GPCR Structure and Function"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amShort Talk Selected from Poster Abstracts
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amRommie Amaro (University of California, San Diego, USA)
"Multi-Scale Dynamics: Molecules to Cells"
10:25 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amLiskin Swint-Kruse (University of Kansas Medical Center, USA)
"Rheostats and Toggle Switches for Modulating Protein Function"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmJosh Wand (University of Pennsylvania, USA)
"Dynamics and Entropy in Protein Function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmStructural Modeling and Sparse Data
Discussion Leader: Martin Blackledge (Institute for Structural Biology, CNRS, France)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJulie Forman-Kay (Hospital for Sick Children, Canada)
"Characterization of Disordered Proteins and Their Dynamic Complexes by Combined Experimental and Computational Approaches"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmShort Talk Selected from Poster Abstracts
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmNikolas Sgourakis (University of California, Santa Cruz, USA)
"Modelling the Structures of Protein Complexes Using Sparse NMR Data"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Biogenesis and Interactions In Vivo
Discussion Leader: Jane Dyson (The Scripps Research Institute, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amLila Gierasch (University of Massachusetts Amherst, USA)
"The Hsp70 Allosteric Chaperone Machine"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amShort Talk Selected from Poster Abstracts
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amBerndt Bukau (University of Heidelberg, Germany)
"Chaperone-Assisted Folding and Assembly of Newly Synthesized Proteins"
10:25 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amK.C. Huang (Stanford University, USA)
"Cytoskeletal Coordination of Bacterial Growth"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmMarina Rodnina (Max Planck Institute for Biophysical Chemistry, Germany)
"Co-Translational Protein Folding on the Ribosome"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Understanding Regulation of Syk Tyrosine Kinase Interaction with Receptor ITAM, from Solution NMR to Computer Simulation
Discussion Leader: Vijay Pande (Stanford University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:40 pmCarol Post (Purdue University, USA)
"Understanding Regulation of Syk Tyrosine Kinase Interaction with Receptor ITAM: From Solution NMR to Computer Simulation"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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