Gordon Research Conferences
Meeting Details
Search:
  GO

Proteoglycans
Gordon Research Conference

The Proteoglycan Arc - From Molecular Mechanisms to Therapeutic Exploitation

Dates

July 10-15, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Jeremy E. Turnbull & Sarah M. Knox

Vice Chair:
Anthony J. Day

Meeting Description

In recent years the proteoglycan community has experienced translation of basic science and understanding of mechanisms regulated by proteoglycans into potential diagnostics, devices, commercial products and therapeutics. The PG Gordon has been fertile ground for instigation of many of these advances. The 2016 program will focus on research areas at the forefront of the field, covering basic aspects of PG research (including new technologies and tools) which provide a foundation to understand their mechanisms of action, and underpin advances in translation to applications. The selected topics will cover several broad areas including new roles of PGs in bioengineering, chronic disease and aging; deciphering the molecular mechanisms of tissue homeostasis, regeneration and inflammation; and defining the role of PGs on intra- and extracellular trafficking and cellular signaling.

The 19th PG GRC will follow the broad format established for the previous highly successful meetings, but with innovations including new session topics, younger investigators as co-leaders of session discussions, and poster previews. A high proportion of invited speakers will be new to the conference, promoting diversity of scientific interactions. Short talks will be selected from submitted abstracts, based on criteria including novelty, fit with session topics and promoting the work of graduate students, postdocs and new investigators. The Chairs are also raising funds with the goal of providing travel bursaries to support the participation of young scientists. The conference will bring together investigators at all career levels and provide a relaxed and exceptionally collegial environment to promote multi-disciplinary collaborations. The outstanding camaraderie of the proteoglycan community provides an unparalleled opportunity for young scientists to network with senior investigators. Open dissemination of ideas between all participants will be maximized, identifying new research directions to advance development of the field.

Related Meeting

This GRC was held in conjunction with the "Proteoglycans" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmLate-Breaking Topics
Discussion Leaders: Lena Kjellen (Uppsala University, Sweden) and Thomas Neill (Thomas Jefferson University, USA)
7:40 pm - 7:50 pmJeffrey Esko (University of California, San Diego, USA)
"Ups and Downs of Heparan Sulfate"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmLaura Kiessling (University of Wisconsin-Madison, USA)
"Glycosaminoglycans and Human Pluripotent Stem Cells"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmRogier Reijmers (VU University Medical Center Amsterdam, The Netherlands)
"Dermatan Sulfate Expression in the Lymph Node Determines Efficacy of the Adaptive Immune Response"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmAaron Petrey (Cleveland Clinic, USA)
"Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmClaire Reynolds (The Pennsylvania State University, USA)
"Heparan Sulfate Proteoglycans Negatively Regulate Autophagy"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmRandy Schekman (University of California, Berkeley, USA)
"Membrane Assembly and Vesicular Transport"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteoglycans: Partners in Cell Signaling and Trafficking
Discussion Leaders: Pascale Zimmermann (Centre de Recherche en Cancérologie de Marseille, France / Katholieke Universiteit Leuven, Belgium) and Lianchun Wang (University of Georgia, USA)
9:00 am - 9:20 amMattias Belting (Lund University, Sweden)
"Proteoglycan Mediated Endocytosis - Implications in Tumor Development"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amShyam Bandari (University of Alabama at Birmingham, USA)
"Chemoexosomes Secreted by Myeloma Cells Deliver Heparanase that Regulates the Behavior of Tumor and Host Cells"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amSarah Haeger (University of Colorado Anschutz Medical Campus, USA)
"Heparan Sulfate Is Shed into the Alveolus After Intratracheal Lung Injury and Facilitates Alveolar Epithelial Growth Factor Signaling and Lung Repair"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amThomas Kornberg (University of California, San Francisco, USA)
"Paracrine Signaling Requires Specific HSPGs in a Structured ECM"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amTatjana Piotrowski (Stowers Institute for Medical Research, USA)
"Signaling Interactions that Control Sensory Lateral Line Development in Zebrafish"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amYingjie Shen (Ohio State University, USA)
"Role of PTPsigma in Alzheimer's Disease"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amHerbert Geller (National Heart, Lung and Blood Institute, NIH, USA)
"Identification of Novel GAG Chain Binding Characteristics in Type IIa Receptor Protein Tyrosine Phosphatases: Implications for Proteoglycan Signaling"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amThomas Neill (Thomas Jefferson University, USA)
"A Novel Mechanistic Link Between Decorin-Evoked Peg3 and TFEB for Endothelial Cell Autophagy"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKarthikeyan Mythreye (University of South Carolina, USA)
"Beyond TGF-β Coreception: Proteoglycan State Dependent Regulation of Signaling by TβRIII/Betaglycan"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTechnology Advances and State-of-the-Art Methods for Proteoglycan Research
Discussion Leaders: Robert Linhardt (Rensselaer Polytechnic Institute, USA) and Matthew Nugent (University of Massachusetts Lowell, USA)
7:30 pm - 7:50 pmGeert-Jan Boons (University of Georgia, USA)
"An Integrated Approach to Uncover Ligands of Heparan Sulfate Binding Proteins"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLinda Hsieh-Wilson (California Institute of Technology, USA)
"Chemical Approaches to Studying Glycosaminoglycans and Their Roles in Axon Regeneration and Neural Circuit Formation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmJennifer Ashworth (University of Nottingham, United Kingdom)
"Multicellular 3D Models of Human Breast Tissue to Replace Rodent Xenograft Models in Breast Cancer Research"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmBradley Whitehead (Cardiff University, United Kingdom)
"Targeting Proteoglycan Metabolites for Increased Nanoparticle Retention in Articular Cartilage Models of Osteoarthritis"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmRalf Richter (CIC biomaGUNE, Spain)
"Single Molecule Force Probe Assays Reveal Distinct Unbinding Mechanics of Hyaluronan from Its Vascular and Lymphatic Endothelial Receptors CD44 and LYVE-1"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJoseph Zaia (Boston University Medical Campus, USA)
"Comprehensive Glycoproteomics of Glioblastoma Biospecimens"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDevelopment and Stem Cells
Discussion Leaders: Natasza Kurpios (Cornell University, USA) and Yu Yamaguchi (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:20 amMolly Shoichet (University of Toronto, Canada)
"Defined Hyaluronan Hydrogels to Emulate the Cell Microenvironment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amVaishali Patel (National Institutes of Health, USA)
"Characterization of Hs3st3a1 and Hs3st3b1 Double Knockout Mice to Study Salivary Gland Development"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amLarisa Haupt (Queensland University of Technology, Australia)
"Proteoglycans and Neural Lineage Commitment: Can We Control Neural Fate?"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amKarin Forsberg-Nilsson (University of Uppsala, Sweden)
"Role of Heparan Sulfate in Differentiation of Embryonic Stem Cells to the Neural Lineage"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amRoger Pocock (Monash University, Australia)
"Non-Canonical TGF-Beta Signalling Drives Neuronal Guidance"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amXiaofang Wang (Texas A&M University Baylor College of Dentistry, USA)
"FAM20B-Catalyzed Proteoglycans Are Critical Regulators of the Signaling Cascades that Control Tooth Number"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmAndrew Chisholm (University of California, San Diego, USA)
"Neural Development in C. elegans"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAgeing and Chronic Diseases
Discussion Leaders: Eri Hirasawa-Arikawa (Juntendo University, Japan) and Dada Pisconti (University of Liverpool, United Kingdom)
7:30 pm - 7:50 pmDulce Papy-Garcia (Université Paris-Est Créteil Val-de-Marne, France)
"Heparan Sulfate 3-O-Sulfotransferases in Ageing and Alzheimer's Disease-Related Tauopathy"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmTaihei Yamada (Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Japan)
"Age-Associated Changes in Heparan Sulfate Structures Impair FGF-2 Signaling in Neurogenesis"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmMaurizio Pacifici (Children's Hospital of Philadelphia, USA)
"Roles of Heparan Sulfate Deficiency in the Pathogenesis of Hereditary Multiple Exostoses, a Pediatric Disorder"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmTarsis Ferreira (University of Cincinnati, USA)
"Gene Therapy of Mucopolysaccharidosis with CRISPR/Cas9-Mediated Genomic DNA Editing"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmVincent Hascall (Cleveland Clinic, USA)
"The Non-Reducing Terminal Trisaccharide of Heparin Blocks Glucose Uptake in Hyperglycemic Dividing Cells"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBioengineering and Regenerative Medicine
Discussion Leaders: Catherine Merry (University of Nottingham, United Kingdom) and John Whitelock (University of New South Wales, Australia)
9:00 am - 9:20 amKaren Christman (University of California, San Diego, USA)
"ECM-Based Hydrogels for Regenerative Medicine"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGlenn Prestwich (University of Utah, USA)
"HA or Not HA? Clinical Paths for Chemically-Modified Hyaluronan"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amMegan Lord (University of New South Wales, Australia)
"Bioengineering Proteoglycan-Based Biomaterials for Vascular Applications"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amChristine Kern (Medical University of South Carolina, USA)
"Three-Dimensional Reconstructions of Extracellular Matrix Remodeling and Lineage-Traced Cells Give Insight into Outflow Tract Development"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amValerie Weaver (University of California, San Francisco, USA)
"Forcing Form and Function"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amJohn Couchman (University of Copenhagen, Denmark)
"Syndecan-4, TRPC Channels and the Interplay Between Cell-ECM and Cell-Cell Adhesion"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmAlyssa Panitch (University of California, Davis, USA)
"Functional Proteoglycan Mimetic: Targeting the Extracellular Matrix for Regenerative Medicine"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMusculoskeletal Biology and Disease
Discussion Leaders: Andrea Vortkamp (University of Duisburg-Essen, Germany) and Marian Young (National Institutes of Health, USA)
7:30 pm - 7:50 pmNancy Schwartz (University of Chicago, USA)
"Proteoglycans in Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmDada Pisconti (University of Liverpool, United Kingdom)
"Syndecan-3 in the Musculoskeletal System: A Double-Edged Sword"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmClare Hughes (Cardiff University, United Kingdom)
"Degradation of Aggrecan by Exosomes Isolated from HEK293 Cell Lines Stably Transfected with Truncated ADAMTS4 Constructs and Its Two Isoforms"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBrendan Lee (Baylor College of Medicine, USA)
"Bone Mass and Collagen-Small Leucine Rich Proteoglycan Interactions"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmDavid Briggs (Imperial College London, United Kingdom)
"Laminin Binds to a Novel GAG-Like Polysaccharide on the Dystroglycan Matrix Receptor"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAnthony Day (University of Manchester, United Kingdom)
"TSG-6 Protects Cartilage and Bone Matrix: Its Development as a Biological for Musculoskeletal Disease"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer and Infectious Diseases
Discussion Leaders: Joanna Phillips (University of California, San Francisco, USA) and Ralph Sanderson (University of Alabama at Birmingham, USA)
9:00 am - 9:20 amAlan Rapraeger (University of Wisconsin-Madison, USA)
"Syndecans and Synstatins: Targeting Receptor Tyrosine Kinases in Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amNikos Karamanos (University of Patras, Greece)
"Estrogen Receptors, EGFR and IGFR Cross-Talk and Syndecan-4 Are Key Regulators of Breast Cancer Cells"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amKatalin Dobra (Karolinska Institute, Sweden)
"Signaling Pathways Regulated by Nuclear Syndecan-1 in Malignancy"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amJoji Iida (Windber Research Institute, USA)
"Role for Chondroitin Sulfate in NEDD9-Mediated Promoting Breast Cancer Cell Growth"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amYeojung Kim (Cleveland Clinic Lerner Research Institute, USA)
"Hyaluronan 35 kDa Treatment Induces Epithelial Tight Junction Protein ZO-1 In Vivo and May Be a Mechanism of Protection in Mice from Citrobacter Infection"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amEric Schmidt (University of Colorado School of Medicine, USA)
"Urinary Glycosaminoglycans as Predictors of Septic Shock Outcomes"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmUlf Lindahl (Uppsala University, Sweden)
"Heparin - Past, Present and Future"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCardiovascular Disease and Inflammatory Processes
Discussion Leaders: Carol De La Motte (Cleveland Clinic, USA) and Jin-Ping Li (Uppsala University, Sweden)
7:30 pm - 7:50 pmPaul Bollyky (Stanford University, USA)
"Regulation of Adaptive Immunity by Proteoglycans and Hyaluronan"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmJens Fischer (Heinrich-Heine-Universitat Dusseldorf, Germany)
"Hyaluronan Synthesis in Cardiovascular Disease"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmLiliana Schaefer (University of Frankfurt, Germany)
"Bimodal Signaling of Biglycan in Inflammation"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmMari Strand (Institute for Experimental Medical Research (IEMR), University of Oslo / Oslo University Hospital, Norway)
"The Heparanase-Syndecan-4 Axis in the Heart: Upregulation in Response to Immune Activation Indicates a Role in Cardiac Inflammation"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmPrem Raj Joseph (University of Texas Medical Branch, USA)
"Structural Basis of GAG-Chemokine Interactions: Implications for In Vivo Neutrophil Trafficking"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRashmin Savani (University of Texas Southwestern Medical Center, USA)
"The Hyaluronan Receptor CD44 Is Necessary for TLR4 Activation of the NLRP3 Inflammasome and the Development of Bronchopulmonary Dysplasia (BPD)"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter