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Nucleosides, Nucleotides and Oligonucleotides
Gordon Research Conference

Exploring the Interface of Biology, Function, Chemistry and Drug Development

Dates

June 28 - July 3, 2015

Location

Salve Regina University
Newport, RI

Organizers

Chair:
Vern L. Schramm

Vice Chair:
Cynthia J. Burrows

Meeting Description

The Nucleosides, Nucleotides and Oligonucleotides Gordon Research Conference is dedicated to understanding the chemistry and biology of its title compounds. A majority of cellular process involve components of these metabolites. Analogues of nucleosides, nucleotides and oligonucleotides are finding increased applications in biotechnology, biology, and medicine. Over thirty compounds in this class are FDA-approved agents to treat cancer, virus infections, metabolic disorders and to interfere with oligonucleotide function. More than thirty new compounds of the conference focus are in the pipeline of preclinical or clinical trials. Finally, many nanotechnology tools depend on oligonucleotides and their chemical analogues to probe structure, function and mechanism.

The 2015 Nucleosides, Nucleotides, and Oligonucleotides Gordon Research Conference will bring together chemists, molecular biologists, biochemists, biologists, medicinal chemists and others interested in understanding all aspects of the enzymes involved in nucleic acid metabolism. Deeper understanding of these pathways is vital to understand related disease processes. New agents, their synthesis and use are expected to be useful in disease treatments. The program will feature a keynote lecture and eight sessions that broadly address current issues in nucleic acid chemistry, DNA repair, discovery of anticancer and antiviral agents, synthetic biology, nucleotide signaling molecules, enzymology of purine and pyrimidine metabolism, and RNA structure and function. An important focus of the meeting is the understanding the chemistry associated with the enzymes of nucleic acid metabolism. Presentations at the Nucleosides, Nucleotides and Oligonucleotides Gordon Conference are designed to increase our basic and applied understanding of related targets in order to exploit them for the creation of new drugs. Academic and industrial researchers will find common ground for productive interactions at this conference. Enhanced participation of science trainees is anticipated by the proximity of this conference to a Gordon Research Seminar on the same topic.

Related Meeting

This GRC was held in conjunction with the "Nucleosides, Nucleotides and Oligonucleotides" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Educating the Genome
Discussion Leader: Vern Schramm (Albert Einstein College of Medicine, USA)
7:40 pm - 8:40 pmAndrew Fire (Stanford University School of Medicine, USA)
"On the Job Training: How Genomes Handle Their Continuing Education"
8:40 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNucleic Acid Therapeutics, Diagnostics and Materials
Discussion Leader: Muthiah Manoharan (Alnylam Pharmaceuticals, USA)
9:00 am - 9:30 amDanzhou Yang (University of Arizona, USA)
"Structure and Function of DNA G-Quadruplex and Its Potential as Drug Target"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amThomas Carell (Ludwig-Maximilians-Universitat Muenchen, Germany)
"New DNA Bases for Epigenetic Control"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amChad Mirkin (Northwestern University, USA)
"Programmable Materials and the Nature of the DNA Bond"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmDavid Giljohann (AuraSense Therapeutics LLC, USA)
"Spherical Nucleic Acids: A New Paradigm in Gene Regulation and Immunomodulatory Therapies"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmGeneral Discussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Patrick Hrdlicka (University of Idaho, USA)
"Invader Probes: Exploiting the Energy of Intercalation to Facilitate Recognition of Chromosomal DNA for Diagnostic Applications"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRNA Metabolism
Discussion Leader: Robert Reenan (Brown University, USA)
7:30 pm - 7:55 pmChuan He (University of Chicago, USA)
"The N6-Methyladenosine (m6A) Modification in Gene Expression Regulation"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmSquire Booker (Pennsylvania State University, USA)
"Radical-Dependent Mechanisms of Post-Transcriptional Modification"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJennifer Heemstra (University of Utah, USA)
"Small-Molecule Detection and Enantiopurity Measurement Using DNA-Based Sensors"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Erika Taylor (Wesleyan University, USA)
"Thoughts About Adenosine: Efforts in Drug Discovery of Nucleoside Utilizing Enzymes"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPurine Metabolism and Polypurine Assembly
Discussion Leader: Karen Anderson (Yale University, USA)
9:00 am - 9:30 amLizbeth Hedstrom (Brandeis University, USA)
"IMP Dehydrogenase: Antimicrobial Discovery and Mechanism"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amWilliam Parker (PNP Therapeutics Inc, USA)
"Use of E. coli Purine Nucleoside Phosphorylase in Cancer Therapy"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amBruce Armitage (Carnegie Mellon University, USA)
"Invasion of G-Quadruplexes by Complementary and Homologous PNA"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmJean-Louis Mergny (Institut Européen de Chimie et Biologie (IECB), France)
"Quadruplexes Are Everywhere"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmGeneral Discussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Beth Stroupe (Florida State University, USA)
"G4s and Nucleoside Diphosphate Kinase in Maize"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNucleotides, Signaling and Probes
Discussion Leader: Donald Ronning (University of Toledo, USA)
7:30 pm - 7:55 pmHerman Sintim (University of Maryland, USA)
"Cyclic Dinucleotide-Mediated Host-Pathogen Interactions Present Opportunities for Novel Anti-Infectives"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmHening Lin (Cornell University, USA)
"Sirtuins and NAD Regulate RAS Family GTPases"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJohn Kozarich (ActivX Biosciences, Inc, USA)
"NT(D)P Acyl Phosphates: Grand Chemoproteomic Inquisitors of Nucleotide Binding Space"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Melanie Etheve-Quelquejeu (Université Paris Descartes, France)
"Synthesis of Modified-RNA to Explore Biological Targets: Application to the Study of Fem Transferase in Bacteria"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNucleic Acid Chemistry and Structure
Discussion Leader: Dipankar Sen (Simon Fraser University, Canada)
9:00 am - 9:30 amShankar Balasubramanian (University of Cambridge, United Kingdom)
"Chemical Biology on the Genome"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMatthew Disney (The Scripps Research Institute, USA)
"Sequence-Based Design of Selective and Potent Small Molecules Targeting RNA"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amPeng Yin (Harvard University, USA)
"Molecular Programming with DNA/RNA"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmCatherine Drennen (Massachusetts Institute of Technology, USA)
"Crystallographic Snapshots of Protein: Nucleic Acid Interactions"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmGeneral Discussion
12:15 pm - 12:25 pmAaron Fleming (University of Utah, USA)
"Effects of Oxidative Stress on the Chemistry and Biology of G-Quadruplexes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNucleoside Analog Chemistry and Functions
Discussion Leader: Peter Tyler (Victoria University of Wellington, New Zealand)
7:30 pm - 7:55 pmMichal Hocek (Academy of Sciences of the Czech Republic, Czech Republic)
"Enzymatic Synthesis of Base-Modified DNA: New Methods and New Applications"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmGary Evans (Victoria University of Wellington, New Zealand)
"Iminosugar Based Nucleoside Analogues: Their Design, Synthesis, Structure and Function"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmKatherine Seley-Radtke (University of Maryland, Baltimore County, USA)
"Flex-Nucleosides - A Strategic Approach to Antiviral Therapeutics"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Lei Li (Indiana University Purdue University Indianapolis, USA)
"Reactivity of Damaged Pyrimidines: A Case Study with 5,6-Dihydro-2'-Deoxyuridine"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAntiviral and Anticancer Approaches
Discussion Leader: Varsha Gandhi (MD Anderson Cancer Center, USA)
9:00 am - 9:30 amTravis Warren (US Army Medical Research Institute of Infectious Diseases, USA)
"Searching for Ebola Virus Therapeutics"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAdrian Ray (Gilead Sciences, Inc., USA)
"On- and Off-Target Pharmacology of HCV NS5B Polymerase Inhibitors"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amGeorge Painter (Emory University, USA)
"The Development of Broadly Active Ribonucleotide Analogs for the Treatment of RNA Viral Infections"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmRonald Raines (University of Wisconsin-Madison, USA)
"Ribonuclease: From Kcat/Km to the Clinic"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:15 pmGeneral Discussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Yimon Aye (Weill Cornell Medical College, USA)
"No Rest for the Reductase: Interrogating RNRs Moonlighting Role"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRNA Enzymology
Discussion Leader: Cynthia Burrows (University of Utah, USA)
7:30 pm - 8:00 pmBrenda Bass (University of Utah, USA)
"Recognition of dsRNA Termini by Dicer's Helicase Domain"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmVahe Bandarian (University of Utah, USA)
"Uncovering the Enzymology of tRNA Hypermodification"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJoanne Stubbe (Massachusetts Institute of Technology, USA)
"The Complexity of Ribonucleotide Reductases: Multiple Mechanisms of Inhibition"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI118204-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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