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Quantitative Genetics & Genomics
Gordon Research Conference

Deciphering the Genetic Basis of Complex Phenotypes for the Benefit of Mankind

Dates

February 22-27, 2015

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Michel A. Georges

Vice Chair:
Ann E. Stapleton

Meeting Description

Genome Wide Association Studies have yielded unprecedented insights in the genetic and molecular architecture of complex traits of medical, agronomic and biological importance. However, the identified loci typically account for only a fraction of the heritability, and - for the majority of them - causative variants and genes remain unknown. By bringing together leading experts in genetics of human, animal, plant, model organism, and natural populations, the 15th conference on Quantitative Genetics and Genomics aims at creating a vibrant forum for the exchange of ideas on (i) the latest advances in the development and application of methods to further improve our comprehension of the genetic basis of multifactorial traits and the evolutionary forces that shape them, as well as (ii) how to translate this new knowledge in improved schemes for personalized medicine in human and for genomic selection in plants and animals.

Related Meeting

This GRC was held in conjunction with the "Quantitative Genetics & Genomics" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGenomic Architecture of Complex Traits - Uncovering Missing Heritability
Discussion Leader: Ed Buckler (Cornell University Institute for Genomic Diversity, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmAlkes Price (Harvard School of Public Health, USA)
"Functional Interpretation of Hidden Heritability of Complex Traits"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmVineeta Agarwala (Broad Institute, USA)
"A Quantitative Population Genetic Framework to Constrain the Range of Genetic Architectures Underlying Complex Human Traits"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJian Yang (The University of Queensland, Australia)
"Estimating Dominance Variance for Human Complex Traits Using Genome-Wide SNPs"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFrom Correlation to Causation - Identifying Causative Variants Underlying Complex Traits
Discussion Leader: Manolis Dermitzakis (University of Geneva Medical School, Switzerland)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amJames Holland (USDA-ARS / North Carolina State University, USA)
"GWAS and Genomic Prediction in Maize"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amHailiang Huang (Massachusetts General Hospital, USA)
"Fine Mapping of Inflammatory Bowel Disease Risk Loci Using Immunochip"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:35 amGil McVean (University of Oxford, United Kingdom)
"Fine-Mapping the Genetic and Mechanistic Basis of Risk of Multiple Sclerosis"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmManolis Dermitzakis (University of Geneva Medical School, Switzerland)
"Population and Personalized Genomics for Human Biology"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmFrom Correlation to Causation - Identifying Causative Genes Underlying Complex Traits
Discussion Leader: Manolis Dermitzakis (University of Geneva Medical School, Switzerland)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:40 pmJonathan Pritchard (Stanford University, USA)
"Effects of Regulatory Variation from Chromatin to Proteins to Complex Traits"
6:40 pm - 6:55 pmDiscussion
6:55 pm - 7:25 pmMichael Calderwood (Dana Farber Cancer Institute, USA)
"Interactome Networks and Human Disease"
7:25 pm - 7:40 pmDiscussion
7:40 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmFrom Correlation to Causation - Identifying Networks Underlying Complex Traits
Discussion Leader: Ann Stapleton (University of North Carolina at Wilmington, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amStig Omholt (Norwegian University of Life Sciences (NMBU), Norway)
"Causally Cohesive Genotype-Phenotype Modelling"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amInes Thiele (Luxembourg Centre for Systems Biomedicine, Luxembourg)
"Investigation of Host-Microbe Interactions Using Computational Modeling"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:20 amNa Cai (Wellcome Trust Centre for Human Genetics, United Kingdom)
"The Mitochondria Genome's Response to Stress"
11:20 am - 11:25 amDiscussion
11:25 am - 11:45 amLior David (The Hebrew University of Jerusalem, Israel)
"Epistatic Interactions Hide and Change the Additive Contribution of QTLs and QTGs to Growth at High Temperature of Yeast"
11:45 am - 11:50 amDiscussion
11:50 am - 12:20 pmGuilherme Rosa (University of Wisconsin, USA)
"Modeling Networks for Prediction and Causal Inference"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPopulation Genomics of Complex Traits
Discussion Leader: Bruce Walsh (University of Arizona, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:40 pmPiter Bijma (Wageningen University, The Netherlands)
"Social Genetics: Theoretical Foundations, Empirical Results and Future Challenges"
6:40 pm - 6:55 pmDiscussion
6:55 pm - 7:10 pmMashaal Sohail (Harvard University, USA)
"Synergistic Epistasis in the Human Genome"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:45 pmMolly Przeworski (Columbia University, USA)
"An Evolutionary Perspective on Human Germline Mutation"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolutionary Genomics of Complex Traits
Discussion Leader: Bruce Walsh (University of Arizona, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amLeif Andersson (Uppsala University, Sweden)
"Population Structure and Genetic Adaptation in Atlantic Herring Explored Using Whole Genome Resequencing and Experimental Pedigrees"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amKathleen Donohue (Duke University, USA)
"Genetic Variation in Seed Dormancy and Annual Plant Life Cycles"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:35 amPeter Andolfatto (Princeton University, USA)
"Admixture Mapping Reveals Genetic Incompatibilities and Genes Underlying Sexually Selected Traits in Xiphophorus Fish"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmDavid Stern (Howard Hughes Medical Institute, USA)
"The Genetic Causes of Courtship Behavior Evolution in the Genus Drosophila"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenomics of Host Pathogen Interactions
Discussion Leader: Daniel Pomp (University of North Carolina, School of Medicine, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:40 pmJeroen Raes (University of Leuven, Belgium)
"Studying the Human Microbiome Using Metagenomics"
6:40 pm - 6:55 pmDiscussion
6:55 pm - 7:10 pmAndrea Doeschl-Wilson (Roslin Institute, United Kingdom)
"Do Genetic Superspreaders of Infections Exist and How to Identify Them?"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:45 pmRan Blekhman (University of Minnesota, USA)
"Genomics of Host-Microbe Interactions in the Tumor Microenvironment"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmEpigenomics of Complex Traits
Discussion Leader: Vincent Colot (Institut de Biologie de l'Ecole Normale Supérieure, France)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amRichard Mott (Wellcome Trust Centre for Human Genetics, United Kingdom)
"Epigenetics and Complex Traits"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amErik Miska (University of Cambridge, United Kingdom)
"The Impact of Transgenerational Epigenetic Inheritance in Nematodes"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:35 amFrank Johannes (University of Groningen, The Netherlands)
"In Search for the Epigenetic Basis of Complex Traits"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmAllan McRae (Queensland Brain Institute, Australia)
"Genetic and Environmental Control of DNA Methylation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTranslational Genomics for Complex Traits
Discussion Leader: Chris Schoen (Technische Universitat Munchen, Germany)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:40 pmMike Goddard (University of Melbourne, Australia)
"Integrated Prediction of Phenotype and Mapping of Causal Variants"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:10 pmLaurence Moreau (Institut National de la Recherche Agronomique (INRA), France)
"Optimizing the Calibration Population for Genomic Selection - Application in Maize"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmAtul Butte (Stanford University School of Medicine, USA)
"Clinical Interpretation of Individuals and Populations Presenting with Whole Genome Sequences"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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