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Calcium Signalling
Gordon Research Conference

Intracellular Calcium Signals: Generation, Function and Therapeutic Intervention

Dates

June 18-23, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Anant B. Parekh

Vice Chairs:
Gary St. John Bird & Mohamed Trebak

Meeting Description

Ca2+ signaling is an evolutionarily conserved pathway that plays prominent roles in cellular function from primitive eukaryotic uni-cellular organisms all the way to humans. Cytoplasmic Ca2+ is a remarkably versatile second messenger - essentially every cell in the body has vital processes controlled by intracellular free Ca2+. These processes include neurotransmission, muscle contraction, metabolism, immune cell activation as well as fertilization and cell death. Given its central role in cell physiology, it is no surprise that aberrant Ca2+ signaling is increasingly recognized as a crucial mechanism underlying cell damage associated with pathophysiology in numerous diseases such as allergy, pancreatitis, Alzheimer's and Parkinson's diseases, cardiac hypertrophy and arrhythmias, and hypertension. In fact, Ca2+ signalling has also been linked to major world health issues including malaria and toxoplasmosis. This conference will bring together the world's leaders in Ca2+ research together with graduate students and postdocs with the primary goal of enhancing our understanding of the molecular mechanisms of Ca2+ signaling and homeostasis, how Ca2+ signals can produce physiological and pathological effects and how Ca2+ channels can be targeted for therapeutic benefit.

Related Meeting

This GRC was held in conjunction with the "Calcium Signalling" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCalcium and Cell Function; Cells, Organs and Organisms
Discussion Leader: Tullio Pozzan (Neuroscience Institute, National Research Council (CNR), Italy)
7:40 pm - 8:05 pmOle Petersen (School of Biosciences, Cardiff University, United Kingdom)
"Calcium and the Pancreas: In Vitro and In Vivo Studies"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmBradley Launikonis (The University of Queensland, Australia)
"Calcium Entry in Skeletal Muscle"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmDavid Paterson (University of Oxford, United Kingdom)
"Pre-Synaptic Calcium Channels, Cyclic Nucleotides and the Heart"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmNicola Hamilton-Whitaker (University College London, United Kingdom)
"Calcium Flux Through TRPA1 Channels and Myelin Damage"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Insights into Ca2+ Stores and Intracellular Calcium Channels
Discussion Leader: Katsuhiko Mikoshiba (RIKEN Brain Science Institute, Japan)
9:00 am - 9:25 amMaike Glitsch (University of Oxford, United Kingdom)
"Regulation of Receptor-Dependent Calcium Release by Environmental Stiffness"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amDavid Yule (University of Rochester, USA)
"Proteolytic Regulation of IP3 Receptor Function"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amGalina Schmunk (University of California, Irvine, USA)
"Defective IP3 Receptor-Mediated Calcium Signalling in Diverse Monogenic Autism Syndrome"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amMasamitsu Iino (Nihon University School of Medicine, Japan)
"Calcium Release: The View from Inside the Stores"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmAndreas Guse (University Medical Center Hamburg-Eppendorf, Germany)
"Integration of NAADP-Dependent Calcium Signalling"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Maike Glitsch (University of Oxford, United Kingdom)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRestricting Ca2+ Signals Spatially: Micro- and Macrodomains
Discussion Leaders: Gary St. John Bird (National Institute of Environmental Health Sciences, NIH, USA) and Mohamed Trebak (Pennsylvania State University, USA)
6:00 pm - 6:25 pmErwin Neher (Max Planck Institute for Biophysical Chemistry, Germany)
"Short-Term Plasticity in the Calyx of Held"
6:25 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmTamas Balla (National Institute of Child Health and Human Development, NIH, USA)
"PIP2 Dynamics and Transport at Membrane Junctions"
7:05 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmAlexei Tepikin (University of Liverpool, United Kingdom)
"Local Calcium Signalling at ER-PM Junctions"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGating of Orai1 Channels
Discussion Leader: James Putney (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:25 amChristoph Romanin (Johannes Kepler University Linz, Austria)
"Molecular Basis of STIM-Orai Interaction"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amPatrick Hogan (La Jolla Institute for Allergy and Immunology, USA)
"Gating of Orai Channels"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amShmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA)
"Control of Calcium Channels by Local PIP2 Microdomains"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:40 amDonald Gill (Pennsylvania State University, USA)
"STIM1 Binding Site Nexus Remotely Controls Orai1 Channel Gating"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmRichard Lewis (Stanford University, USA)
"Conformational Dynamics of the STIM1 Cytosolic Domain"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmVOCCs and TRPS
Discussion Leader: Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA)
6:00 pm - 6:25 pmJoerg Striessnig (University of Innsbruck, Austria)
"Cav1.3 L-Type Calcium Channels in Brain Disorders"
6:25 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmAnnette Dolphin (University College London, United Kingdom)
"New Insight into α2δ Regulation of Neuronal N-Type Calcium Channels"
7:05 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmReinhold Penner (The Queen's Medical Center / University of Hawaii, USA)
"Regulation of CRAC Channels by the 'Chanzyme' TRPM7"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondrial Ca2+ Dynamics
Discussion Leader: Andrew Thomas (Rutgers University, USA)
9:00 am - 9:25 amFabiana Perocchi (Ludwig Maximilian University of Munich, Germany)
"MCU Stoichiometry and Binding Partners Identified Through a Proteomic Approach"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amKevin Foskett (Perelman School of Medicine, University of Pennsylvania, USA)
"Interorganellar Crosstalk Between the ER and Mitochondria"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amElisa Greotti (Institute of Neuroscience, National Research Council (CNR), Italy)
"mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amIsrael Sekler (Ben-Gurion University of the Negev, Israel)
"Mitochondrial Function Deciphered Through Optogenetics"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmJorgina Satrustegui (Universidad Autónoma de Madrid, Spain)
"Calcium Regulation of Mitochondrial Carriers"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTargeting Ca2+ Channels for Drug Discovery: The View from Pharma
Discussion Leader: Colin Taylor (University of Cambridge, United Kingdom)
6:00 pm - 6:25 pmKlaus Seuwen (Novartis Institutes for Biomedical Research, Switzerland)
"Novel Approaches to Target Calcium-Mobilising Receptors"
6:25 pm - 6:40 pmDiscussion
6:40 pm - 6:50 pmGrace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, USA)
"Targeting Ryanodine Receptors as a Therapeutic Strategy for Neurodegenerative Disease and Brain Injury"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmGeert Bultynck (KU Leuven, Belgium)
"Reciprocal Sensitivity of Diffuse Large B-Cell Lymphoma Cells to Bcl-2 Inhibitors BIRD-2 Versus Venetoclax"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmSrikant Viswanadha (Rhizen Pharmaceuticals SA, Switzerland)
"RP3128: An Oral Calcium Release Activated Calcium (CRAC) Channel Inhibitor for Immune-Inflammatory Disorders"
7:35 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCa2+ Signals in Inflammatory and Immunological Disease
Discussion Leader: Aldebaran Hofer (Harvard Medical School / VA Boston Health Care System, USA)
9:00 am - 9:25 amMurali Prakriya (Northwestern University, USA)
"Calcium Signals and Airway Epithelial Cell Activation"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amNicolas Demaurex (University of Geneva, Switzerland)
"Calcium Signalling and Neutrophil Function"
10:05 am - 10:20 amDiscussion
10:20 am - 10:30 amMiryam Hortua Triana (Center for Tropical and Emerging Global Diseases, University of Georgia, USA)
"Two Mechanisms of Calcium Entry in Toxoplasma gondii, Each with Specific Roles in Virulence Pathways"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amStefan Feske (New York University School of Medicine, USA)
"Store-Operated Calcium Entry in Autoimmunity"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmMarkus Hoth (Saarland University, Germany)
"Calcium Signatures of T-Cell and NK Cell Cytotoxicity"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmLate-Breaking Topics / Keynote Session: Mitochondria - Conductors of the Calcium Orchestra
Discussion Leader: Anant Parekh (Oxford University, United Kingdom)
6:00 pm - 6:15 pmKozo Hamada (RIKEN, Japan)
"Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography"
6:15 pm - 6:25 pmDiscussion
6:25 pm - 6:40 pmOrnella Manfra (University of Oslo, Norway)
"Super-Resolution (dSTORM) Imaging of Calcium Handling Proteins in Cardiomyocytes"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:40 pmRosario Rizzuto (University of Padova, Italy)
"Mitochondria: Conductors of the Calcium Orchestra"
7:40 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number 1R13Al131591-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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