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Antimicrobial Peptides
Gordon Research Conference

Basic and Translational Aspects

Dates

May 3-8, 2015

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Pieter S. Hiemstra & Julia Dorin

Vice Chairs:
Wuyuan Lu & Charles Bevins

Application Deadline

The application deadline for this meeting was April 5, 2015. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

Antimicrobial peptides (AMPs) are essential components of host defense against infections present in all domains of life. These peptides display marked activity against bacteria, fungi, viruses and parasites. But it has become increasingly clear however that AMPs and structurally related peptides also possess functions distinct from this broad-spectrum antimicrobial activity. These include realisation of roles in inflammation, immunity, wound healing and also fertility. The focus of the 2015 Gordon Conference of Antimicrobial Peptides is clear from its subtitle: basic and translational aspects. These aspects will be discussed by invited speakers, but also by scientists that submit abstracts to the meeting. The conference is aimed at scientists from a diverse array of disciplines, including microbiology, biochemistry, animal and plant biology, medicine, immunology, cell biology and drug development. The Conference will address the most innovative and up-to-date science on a range of topics in the field of AMPs research, and seek to integrate the different perspectives on the role of AMPs. AMPs play a major role at epithelial surface, where commensal and pathogenic micro-organisms are present. The intriguing insights provided by analysis of the microbiome at these epithelial surfaces will therefore have a major impact on our understanding of the role of AMPs at these surfaces. Other sessions will be focused on: regulation of expression of AMPs; microbial mechanisms to prevent the cytotoxic activity of AMPs; and their role in health and disease. Application of AMPs as therapeutics, and opportunities for use in agriculture and infection control will also be discussed.

The informal and collegial atmosphere of the Conference is an ideal environment for scientific discussions and brainstorming, in formal and informal settings throughout the day. The presence of scientist from different disciplines offers opportunities for discussions that few meetings provide, in and outside the unique "Late-Breaking Topics Corner".

Related Meeting

This GRC will be held in conjunction with the "Antimicrobial Peptides" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Impact of Dysbiosis, Infection Models and AMPs
This opening session will include the keynote speakers and the young investigator presentation.
Discussion Leaders: Gill Diamond (University of Florida, USA) and Nita Salzman (Medical College of Wisconsin, USA)
7:40 pm - 8:20 pmKeynote: Richard Flavell (Yale University, USA)
"Dysbiosis and Disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmKeynote: Lalita Ramakrishnan (University of Cambridge, United Kingdom)
"Lessons for Tuberculosis Pathogenesis and Treatment from the Zebrafish"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmDmitri Kudryashov (The Ohio State University, USA)
"Young Investigator Award: Defensins Act as Anti-Chaperones Against Thermodynamically Unstable Bacterial Toxins"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAMPs and the Microbiome at Epithelial Surfaces
Discussion Leaders: Donald Davidson (University of Edinburgh, United Kingdom) and Henk Haagsman (Utrecht University, The Netherlands)
9:00 am - 9:20 amMathias Hornef (Aachen RWTH University, Germany)
"Postnatal Maturation Dynamics of the Gut Mucosal Immune System: The Coming of Age of AMPs in the Gut"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amBenjamin Marsland (University Hospital of Lausanne, Switzerland)
"Influence of Gut and Lung Microbiota on the Development of Allergic Airways Inflammation"
9:55 am - 10:10 amDiscussion
10:10 am - 10:30 amBirgit Schittek (University of Tuebingen, Germany)
"Innate Host Defense Against S. aureus Infection of the Skin"
10:30 am - 10:45 amDiscussion
10:45 am - 11:10 amCoffee Break
11:10 am - 11:30 amNita Salzman (Medical College of Wisconsin, USA)
"Influence of AMPs on Microbiota and Inflammation"
11:30 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Delphine Destoumieux-Garzon (University of Montpellier, Host-Pathogen Interactions-Environments, CNRS, France)
"Outer Membrane Vesicles in the Pathogenesis of Vibrio tasmaniensis LGP32: Resistance to Antimicrobial Peptides and Delivery of Virulence Factors"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Fiona Semple (University of Edinburgh, United Kingdom)
"Increased Levels of hBD3 in the Gastrointestinal Tract Influence the Microbiome"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Ottavia Romoli (University of Padova, Italy)
"Antimicrobial Peptide-Mediated Immune Response in Four Bombyx mori Strains Infected with Gram Positive and Negative Pathogens"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAMPs Throughout Evolution
Discussion Leaders: Eefjan Breukink (Utrecht University, The Netherlands) and Gudmundur Hrafn Gudmundsson (University of Iceland, Iceland)
6:00 pm - 6:20 pmMande Holford (Hunter College / City University of New York, USA)
"Evolution, Discovery and Function of Peptide Toxins in Marine Snails"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJens Rolff (Free University Berlin, Germany)
"Bacterial Resistance Evolution Against (Beetle) AMPs"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMaren Von Kockritz-Blickwede (University of Veterinary Medicine Hannover, Germany)
"The Role of Antimicrobial Peptides in the Formation and Stabilization of Neutrophil Extracellular Traps"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSelected from Poster Abstracts: Sohaib Malik (Uppsala University, Sweden)
"Resistance Development to Cycloviolacin O2"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Steven Wasserman (University of California, San Diego, USA)
"An Effector Peptide Family Required for Drosophila Toll-Mediated Immunity"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanism of Antimicrobial Action of AMPs
Discussion Leaders: Hans-Georg Sahl (University of Bonn, Germany) and William Shafer (Emory University School of Medicine, USA)
9:00 am - 9:20 amDaniel Wozniak (The Ohio State University, USA)
"Mutagenesis by Host Antimicrobial Peptides: Insights into Microbial Evolution During Chronic Infections"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amShonna McBride (Emory University School of Medicine, USA)
"Differences in Regulation of AMP Resistance Mechanisms Between Historical and Epidemic Isolates of Clostridium difficile"
9:55 am - 10:10 amDiscussion
10:10 am - 10:30 amMichaela Wenzel (University of Amsterdam, The Netherlands)
"Delocalization of Bacterial Peripheral Membrane Proteins by Small Cationic Antimicrobial Peptides"
10:30 am - 10:45 amDiscussion
10:45 am - 11:10 amCoffee Break
11:10 am - 11:30 amKimberly Kline (Nanyang Technological University, Singapore)
"Focal Targeting of Defensins to Bacterial Membranes"
11:30 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Rokeya Sultana Rekha (Karolinska Institute, Sweden)
"Phenylbutyrate Induces LL-37-Dependent Autophagy and Intracellular Killing of Mycobacterium tuberculosis in Human Macrophages"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Kathi Scheinpflug (Leibniz-Institute for Molecular Pharmacology, Germany)
"Evidence for a Novel Mechanism of Antimicrobial Action of a Cyclic R-,W-Rich Hexapeptide"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Yechiel Shai (Weizmann Institute of Science, Israel)
"The Underlying Mechanism of Biofilm Inhibition and Degradation by Antimicrobial Peptides"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAMPs as Immune Modulators
Discussion Leaders: Paul McCray, Jr. (University of Iowa College of Medicine, USA) and Anne Van Der Does (Karolinska Institutet, The Netherlands)
6:00 pm - 6:20 pmRobert Hancock (University of British Columbia, Canada)
"Development of IDR Peptides as Therapeutics and Vaccine Adjuvants"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMohini Gray (University of Edinburgh, United Kingdom)
"Modulation of Inflammation by α-Defensins"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmHenk Haagsman (Utrecht University, The Netherlands)
"Avian AMPs as Host Defense Peptides (HDPs) in Immunoregulation"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSelected from Poster Abstracts: Donald Davidson (University of Edinburgh, United Kingdom)
"Cathelicidins Modulate Innate and Adaptive Cellular Responses at Epithelial Surfaces in the Lung and the Gastrointestinal Tract"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Jasmijn Schrumpf (Leiden University Medical Center, The Netherlands)
"Vitamin D-Mediated Expression of hCAP18/LL-37 and Killing of NTHi Is Reduced After Exposure to TNF-Alpha and IL-1Beta in Primary Bronchial Epithelial Cells"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAMP Dysfunction: Role in Disease
Discussion Leaders: Robert Bals (University Hospital of Saarland, Germany) and Michael Otto (Nat. Institute of Allergy and Infectious Diseases, USA)
9:00 am - 9:20 amEdward Hollox (University of Leicester, United Kingdom)
"Copy Number Variation and Polymorphisms in Defensin Genes: Links to Chronic Disease?"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amPaul McCray, Jr. (University of Iowa College of Medicine, USA)
"Effects of Airway Surface Liquid pH on Host Defense in Cystic Fibrosis"
9:55 am - 10:10 amDiscussion
10:10 am - 10:30 amLhousseine Touqui (Pasteur Institute, France)
"A Role for Group IIA Secreted Phospholipase A2 in the Modulation of Lung Microbiota in Cystic Fibrosis"
10:30 am - 10:45 amDiscussion
10:45 am - 11:10 amCoffee Break
11:10 am - 11:30 amJulien Diana (INSERM U1151-Universite Paris Descartes, France)
"Dual Role of the Murine Cathelicidin in Type 1 Diabetes"
11:30 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Colin Bingle (University of Sheffield, United Kingdom)
"'Ears to PLUNC: A Role for BPIFA1/SPLUNC1 in Pathogenesis of Otitis Media"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Andreas Essig (ETH Zurich, Switzerland)
"Fungal AMPs as Secreted Defense Line Against Bacteria"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Martin Lam (European Medical School, University of Oldenburg, Germany)
"Skin Electroporation of a Plasmid Encoding hCAP-18/LL-37 Host Defense Peptide Promotes Wound Healing"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNovel Functions of AMPs
Discussion Leaders: Neeloffer Mookherjee (University of Manitoba, Canada) and Aaron Weinberg (Case Western Reserve University, USA)
6:00 pm - 6:20 pmSergio Lira (Mount Sinai School of Medicine, USA)
"Interaction Between Host Innate Immunity and Microbiota in the Development of Intestinal Neoplasma"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmDavid Hoskin (Dalhousie University, Canada)
"AMPs as Anti-Cancer Agents: Discovery and Mechanism of Action"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmHsiao Chang Chan (The Chinese University of Hong Kong, China)
"Dual Role of Human Beta-Defensin 1 in Defending Male Fertility"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSelected from Poster Abstracts: Lee Schnaider (Tel Aviv University, Israel)
"Deciphering the Potential Functional Link Between Antimicrobial and Amyloidogenic Peptides"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Erik de Leeuw (University of Maryland, Baltimore, USA)
"Turning Defense into Offense: Targeting the TNF Receptor PLAD Domain"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmNovel AMPs
Discussion Leaders: Adrian Gombart (Oregon State University, USA) and Jens Schroeder (University Hospital, Christian-Albrechts University of Kiel, Germany)
9:00 am - 9:20 amMarc Devocelle (Royal College of Surgeons in Ireland, Ireland)
"Host Defence Pro-Peptides Activated by Disease-Associated Enzymes"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amMichael Otto (Nat. Institute of Allergy and Infectious Diseases, USA)
"Phenol-Soluble Modulins and Other AMPs in Staphylococcal Pathogenesis"
9:55 am - 10:10 amDiscussion
10:10 am - 10:30 amKev Dhaliwal (University of Edinburgh, United Kingdom)
"Optical Molecular Imaging of Bacteria in the Alveolar Space with Smart AMPs"
10:30 am - 10:45 amDiscussion
10:45 am - 11:10 amCoffee Break
11:10 am - 11:30 amPeter Nibbering (Leiden University Medical Center, The Netherlands)
"Development and Formulation of Antimicrobial Peptides for Treatment of Skin Infections with Methicillin Resistant Staphylococcus aureus"
11:30 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Simon Döhrmann (University of California, San Diego, USA)
"GAS M1 Protein Protects Against Histone Killing"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Marina Rautenbach (Stellenbosch University, South Africa)
"The Antiplasmodial Activity of Cyclodecapeptides from Bacillus aneurinolyticus Share a Target with Chloroquine"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Jens Schroeder (University Hospital, Christian-Albrechts University of Kiel, Germany)
"Intrinsically Disordered Antimicrobial Peptides (IDAMPs): A Novel Family of Broad-Spectrum and Ribosome-Targeting Antimicrobials"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmApplications of AMPs: Putting Them to Work
Discussion Leaders: Jan Wehkamp (University Hospital Tubingen, Germany) and Michael Zasloff (Georgetown University Medical Center, USA)
6:00 pm - 6:20 pmBirgitta Agerberth (Karolinska Institutet, Sweden)
"Boosting AMPs Production as a Therapeutic Strategy for Treatment of Infectious Diseases"
6:20 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmVictor Nizet (University of California, San Diego, USA)
"Exploiting Synergies Between Conventional Antibiotics and AMPs to Treat Multi-Drug Resistant Infections"
6:55 pm - 7:10 pmDiscussion
7:10 pm - 8:00 pmLate-Breaking Topics
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI117912-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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