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Salivary Glands & Exocrine Biology
Gordon Research Conference

Understanding Development, Function and Regeneration of Secretory Tissues: Novel Signaling Pathways and Approaches to Treat Exocrine Disorders

Dates

February 19-24, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Gary A. Weisman & Catherine E. Ovitt

Vice Chairs:
Sarah M. Knox & Stefan Ruhl

Meeting Description

The Gordon Research Conference (GRC) on Salivary Glands and Exocrine Biology will include sessions on exocrine gland development, regenerative approaches, functional relevance of salivary proteins, membrane functions in exocrine glands, understanding the etiology of autoimmune disease, targeting inflammation to retard disease pathogenesis and current topics in cell biology of exocrine glands. Invited speakers for the GRC will include eminent scientists from academia, industry and government and talks will include both senior and junior scientists from diverse fields who will present unpublished research findings on subjects of greatest interest to the field. This GRC will include a Graduate Research Seminar (GRS) to be held just prior to the GRC that will invite only speakers who are graduate students and postdoctoral associates in a wide variety of laboratories worldwide. In addition, poster sessions will be held daily at the GRC and GRS to enable all attendees to present and discuss their data in an open forum. The overall goal of the GRC and GRS will be to foster scientific exchanges and engender research collaborations in disciplines that are viewed as having a major impact on the development of novel strategies to improve human health. Specific Aims include: 1) to present a program of topical interest to attendees in a pleasant setting where they will have opportunities to present unpublished findings before a knowledgeable audience and engage in a wide range of critical research discussions; 2) to offer for the first time, a GRS to be attended by graduate students and postdoctoral associates who will present their novel research findings before an audience of their peers and; 3) to emphasize presentations on state-of-the-art methodologies of interest to the exocrine biology field towards the goal of developing innovative approaches to the improvement of human health by preventing disorders of secretory organs.

Related Meeting

This GRC was held in conjunction with the "Salivary Glands & Exocrine Biology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Frontiers in Tissue Engineering
Discussion Leaders: Gary Weisman (University of Missouri, USA) and Catherine Ovitt (University of Rochester, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmDavid Mooney (John A. Paulson School of Engineering and Applied Sciences, Harvard University, USA)
"Improving Stem Cell Therapeutics with Mechanobiology"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmLinda Griffith (Massachusetts Institute of Technology, USA)
"Decoding Epithelial-Stromal Cross Talk with Synthetic Extracellular Matrix"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmExocrine Gland Development
Discussion Leaders: Deborah Andrew (Johns Hopkins School of Medicine, USA) and Matthew Hoffman (National Institute of Dental and Craniofacial Research, NIH, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amHelen Makarenkova (The Scripps Research Institute, USA)
"The Dynamics of Murine Lacrimal Gland Stem/Progenitor Cells During Development, Homeostasis and Regeneration"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amLisa Sandell (University of Louisville, USA)
"Signaling by the Vitamin A Derivative Retinoic Acid Regulates Development of Submandibular Salivary Epithelium"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Aaron Mattingly (University of California, San Francisco, USA)
"Neuregulin-1/ERBB3 Signaling Is Essential for Mouse Salivary Gland Development and Acinar Cell Formation"
10:15 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Rose-Anne Romano (State University of New York at Buffalo, USA)
"Chromatin Fingerprinting of Enhancers and Super-Enhancers in the Control of Cell Fate and Identity in the Salivary Gland"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:20 amAbigail Tucker (King's College London, United Kingdom)
"Fgf10 and Sox9 Interactions in Developing Salivary Glands"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKenneth Yamada (National Institute of Dental and Craniofacial Research, NIH, USA)
"3D Dynamics of Cells and Matrix in Branching Morphogenesis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Akiko Shitara (National Institutes of Health, USA)
"Cdc42 Is Required for the Maintenance and Formation of Apical Lumens in Tubular Organs"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Bob Varelas (Boston University School of Medicine, USA)
"The Hippo Pathway Effector YAP Is an Essential Regulator of Submandibular Gland Ductal Progenitor Patterning"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEmerging Concepts in Regenerative Medicine
Discussion Leaders: Darlene Dartt (Schepens Eye Research Institute, Harvard University, USA) and Mary Farach-Carson (University of Texas Health Science Center at Houston, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmQuynh-Thu Le (Stanford University, USA)
"Activating the ALDH3 Pathway to Mitigate Radiation-Related Xerostomia"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDriss Zoukhri (Tufts University, USA)
"Mechanisms of Lacrimal Gland Repair"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmDanielle Benoit (University of Rochester, USA)
"Tunable Hydrogel Microenvironments to Study Salivary Gland Cell Phenotype and Function"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmMelinda Larsen (University at Albany, SUNY, USA)
"From Developmental Mechanisms to Regenerative Strategies"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFunctional Relevance of Mucins and Salivary Proteins
Discussion Leaders: Mary Reyland (University of Colorado Denver, USA) and Stefan Ruhl (University at Buffalo, SUNY, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amGordon Proctor (King's College London, United Kingdom)
"Salivary Mucin Interaction with Mucosal Surfaces"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amPaul Breslin (Rutgers University, USA)
"The Role of Salivary Amylase in Taste and Regulatory Physiology"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Joao Ferreira (National University of Singapore, Singapore)
"Three-Dimensional Bioprinting Nanotechnologies for the Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration"
10:15 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Omer Gokcumen (State University of New York at Buffalo, USA)
"Archaic Hominin Introgression and Microbial Interactions Shaped Extant Salivary MUC7 Variants in Modern Humans"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:20 amEva Helmerhorst (Boston University, USA)
"Oral Microbe-Derived Gluten-Degrading Proteases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amWalter Siqueira (University of Western Ontario, Canada)
"The Use of Nanotechnology on Salivary Proteins for the Prevention and Treatment of Oral Diseases"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Michael Passineau (Allegheny Health Network, USA)
"Activation of AQP1 in a Human Cell Line Targeted Epigenetic Editing"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Sarah Pringle (University of Groningen, The Netherlands)
"Exhaustion of Salivary Gland Stem Cells Causes Hyposalivation in Primary Sjögren's Syndrome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Functions in Exocrine Glands
Discussion Leaders: Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA) and Brij Singh (University of North Dakota, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmRoberto Weigert (National Cancer Institute, NIH, USA)
"Molecular Mechanisms of Membrane Remodeling During Regulated Exocytosis in Live Animals"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmSarah Hamm-Alvarez (Keck School of Medicine, University of Southern California, USA)
"Influence of Rab Proteins on Protein Secretion Profiles in Lacrimal Gland"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmDavid Yule (University of Rochester, USA)
"Ca2+ Signaling Through Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmShmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA)
"Fix the Duct, Fix the Acini: CFTR and Sjögren's Syndrome"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmUnderstanding the Etiology of Autoimmune Disease: From Mice to Humans
Discussion Leaders: Ammon Peck (University of Florida, USA) and Julian Ambrus (School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMarkus Hardt (Forsyth Institute, USA)
"Proteolytic Profiles Associated with Sjögren's Syndrome"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRachel Ettinger (MedImmune, USA)
"Sjögren's Syndrome Arises Due to Early-Life Immune Dysregulation"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: A. Darise Farris (Oklahoma Medical Research Foundation, USA)
"From Salivary Gland Lymphocyte Receptors to Salivary Gland Antigen Identification in Sjögren's Syndrome"
10:15 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: David Ann (Beckman Research Institute, City of Hope, USA)
"Autophagy Provides Asparagine to Promote Oncogenic KRAS-Driven Salivary Gland Progression"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:20 amUmesh Deshmukh (Oklahoma Medical Research Foundation, USA)
"Microbes, Innate Immunity and the Salivary Gland"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJay Chiorini (National Institute of Dental and Craniofacial Research, NIH, USA)
"The Role of Epigenetics in Salivary Gland Dysfunction"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Jill Kramer (State University of New York at Buffalo, USA)
"MyD88 Deficiency Mitigates the Severity of Primary Sjögren's Syndrome"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Cuong Nguyen (University of Florida, USA)
"Single-Cell Microengraving Analysis Reveals a Restricted and Sexual Dimorphic T Cell Receptor Repertoire of Interferon-γ and Interleukin-17A Producing T Cells in the Salivary Gland of Sjögren's Syndrome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTargeting Inflammation to Retard Disease Pathogenesis
Discussion Leaders: Maria Kukuruzinska (Boston University, USA) and David Ann (Beckman Research Institute, City of Hope, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmMarco Colonna (Washington University School of Medicine in St. Louis, USA)
"The Role of TGFβ in the Development and Function of Salivary Gland Innate Lymphoid Cells"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmYuka Kanno (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Lymphocyte Genes, Genomes and New Drugs"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmHelen Braley-Mullen (University of Missouri, USA)
"NOD.H-2h4 Mouse Mutants Provide Robust Models for Defining Mechanisms and Targeting Inflammation in Sjögren's Syndrome"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmKirsten Limesand (University of Arizona, USA)
"Signaling Mechanisms Involved in Radiation-Induced Chronic Loss of Function"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Exocrine Gland Repair and Regeneration
Discussion Leaders: Isabelle Lombaert (University of Michigan, USA) and Rob Coppes (University Medical Center Groningen, The Netherlands)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMatthias Hebrok (University of California, San Francisco, USA)
"Dedifferentiation and Transformation of Pancreatic Exocrine Cells"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amStephen Konieczny (Purdue University, USA)
"Clearing the MIST: Deciphering New Transcriptional Networks that Govern Secretory Throughput and the Unfolded Protein Response"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Kimberly Jasmer-McDonald (University of Missouri, USA)
"Exploring the Role of P2Y2 Nucleotide Receptors in a Novel Autoimmune Mouse Model of Sjögren's Syndrome"
10:15 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Pei-Lun Weng (University of Rochester Medical Center, USA)
"Lineage Tracing of Keratin 5 and Axin 2-Positive Cells in Adult Salivary Gland Shows No Contribution to Acinar Cells"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:20 amJason Mills (Washington University School of Medicine in St. Louis, USA)
"How Cells Scale Their Secretory Apparatus in Homeostasis and Cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJonathan Axelrod (Hadassah Medical Center, Hebrew University of Jerusalem, Israel)
"Senescence-Mediated Loss of Salivary Gland Function: Is It the End of the Road?"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Sten Wie (University of Colorado Anschutz Medical Campus, USA)
"Inhibition of PKC Delta Confers Radioprotection to the Salivary Gland"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Danielle Wu (Rice University, USA)
"Differentiation of Salivary Human Stem/Progenitor Cell Pedigrees in Bioactive 3D Hydrogels"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Clinical Trials for Sjögren's Syndrome
Discussion Leaders: Sarah Knox (University of California, San Francisco, USA) and David Wong (UCLA School of Dentistry, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:30 pmRobert Fox (Scripps Memorial Hospital and Research Foundation, USA)
"Management of Sjögren's Syndrome: Where Do We Go from Here?"
8:30 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13DE026651-01 from the National Institutes of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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