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Malaria
Gordon Research Conference

The Basic Science of Malaria: A Springboard for New Approaches to Control and Elimination

Dates

July 2-7, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chair:
Maria Mota

Vice Chair:
Peter D. Crompton

Meeting Description

New tools and strategies are needed to accelerate progress toward malaria control and elimination. To successfully meet this challenge we need a clearer understanding of the complex interplay between the Plasmodium parasite, its mosquito vector and the vertebrate host it infects. The 2017 Gordon Research Conference (GRC) on Malaria will focus on the biology of Plasmodium infection at every stage of the parasite's life cycle. To set the stage for a thought-provoking meeting, the program is composed of both malaria and non-malaria scientists at the forefront of their fields. We hope to stimulate innovative ideas and collaborations by providing a forum to discuss cutting edge basic malaria research as well as recent advances in non-malaria fields with potential relevance to malaria. The conference will be preceded by the Malaria Gordon Research Seminar (GRS) from July 1-2, 2017 targeted at graduate students, post-docs and junior scientists.

Related Meeting

This GRC was held in conjunction with the "Malaria" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Progress and Next Steps in Understanding the Parasite, Vector and Host
This session will be composed by lectures of leaders in the field that will put in perspective the past achievements and present challenges of malaria research, setting the tone for the entire conference and scientific discussions.
Discussion Leader: Maria Mota (Instituto de Medicina Molecular, University of Lisbon, Portugal)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmCarolina Barillas-Mury (National Institutes of Health, USA)
"Can a Pfs47-Based Vaccine Recruit the Mosquito Immune System to Disrupt Malaria Transmission?"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmFidel Zavala (Johns Hopkins University, USA)
"Dissecting Protective Immune Mechanisms Against PE Stages"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmAlan Cowman (Walter and Eliza Hall Institute of Medical Research, Australia)
"Understanding Red Blood Cell Infection and Pathogenicity"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWithin the Mosquito Vector, Basic Biology
Discussion Leader: Carolina Barillas-Mury (National Institutes of Health, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amFlaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
"Studying Anopheles-Plasmodium Interactions: From Basic Research to Applications for Malaria Control"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amElena Levashina (Max Planck Institute for Infection Biology, Germany)
"Environmental and Genetic Factors in Mosquito Resistance to Plasmodium"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amOliver Billker (Wellcome Trust Sanger Institute, United Kingdom)
"Regulation of Sexual Development in P. berghei"
11:00 am - 11:10 amDiscussion
11:10 am - 11:20 amSelected from Poster Abstracts: Ekta Saini (International Centre for Genetic Engineering and Biotechnology (ICGEB), India)
"Photosensitized INA-Labelled Protein 1 (PhIL1) Is a Novel Component of the Inner Membrane Complex of All Invasive and Motile Stages of Plasmodium"
11:20 am - 11:25 amDiscussion
11:25 am - 11:35 amSelected from Poster Abstracts: Ashley Vaughan (Center for Infectious Disease Research, USA)
"A Plasmodium ABC Transporter Plays an Essential Role in the Uptake of Lipid to the Developing Oocyst"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmMatthias Marti (University of Glasgow, United Kingdom)
"Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBeyond the Bench of the Plasmodium-Anopheles Interactions
Discussion Leader: Flaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmDavid Sacks (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Sand Fly Molecules Controlling the Development of Transmissible Infections"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmShirley Luckhart (University of Idaho, USA)
"An Ancient Plant and Animal Hormone Functions as a Transmission Blocking Therapeutic to Control Immunity to Erythrocytic and Sporogonic Stages of Plasmodium falciparum"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmSelected from Poster Abstracts: Katharine Collins (QIMR Berghofer Medical Research Institute, Australia)
"Human to Mosquito Transmission of P. falciparum and P. vivax During Controlled Human Malaria Infection"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmGeorge Dimopoulos (Johns Hopkins Bloomberg School of Public Health, USA)
"Exploring Strategies for Plasmodium Suppression in the Mosquito"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBasic Biology of the Pre-Erythrocytic Stages
Discussion Leader: Stefan Kappe (Center for Infectious Disease Research, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amIrwin Arias (Senior Scientist Emeritus, NIH, USA)
"Polarizing Challenges for Hepatocytes and Malaria"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amOlivier Silvie (Centre d'Immunologie et des Maladies Infectieuses, France)
"New Insights into Host Cell and Parasite Determinants of Plasmodium Sporozoite Entry into Hepatocytes"
10:00 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amPhotini Sinnis (Johns Hopkins Bloomberg School of Public Health, USA)
"Establishment of Malaria Infection: Transmission Dynamics and Roadblocks"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Annie Yang (Radboud University Medical Center, The Netherlands)
"O-Glycosylation of Sporozoite Thrombospondin Repeats Is Required for Liver Infection by Plasmodium falciparum"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Erika Flannery (Center for Infectious Disease Research, USA)
"Perturbation of Plasmodium vivax Hypnozoite Formation, Growth and Reactivation In Vivo in a Human-Liver Chimeric Mouse"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Alexandra Spencer (University of Oxford, United Kingdom)
"Factors Defining the Ability of a Liver-Stage Malaria Antigen to Reactivate Protective CD8+ T Cell Responses"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Brandon Sack (Center for Infectious Disease Research, USA)
"Non-Classical Antibodies to Prevent Malaria Infection"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmVolker Heussler (University of Bern, Switzerland)
"Phenotypic Analysis of KO Parasites for Genes Identified by High-Throughput Screening"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Pre-Erythrocytic Stages, Beyond the Bench
Discussion Leader: Photini Sinnis (Johns Hopkins Bloomberg School of Public Health, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmCharles Rice (The Rockefeller University, USA)
"New Insights into Cell-Specific Innate Immunity"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmStefan Kappe (Center for Infectious Disease Research, USA)
"Preventing Pre-Erythrocytic Malaria Infection"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmIan Cockburn (Australian National University, Australia)
"Why Don't We Make Better Antibody and B Cell Responses to the Circumsporozoite Protein?"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmElizabeth Winzeler (University of California, San Diego, USA)
"Finding New Compounds that Kill Liver Stage Parasites"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMalaria Blood Stage Biology
Discussion Leader: Alan Cowman (Walter and Eliza Hall Institute of Medical Research, Australia)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amJudy Lieberman (Harvard Medical School, USA)
"Killer Lymphocytes Recognize and Kill Blood Stage Falciparum Malaria and Other Protozoan Parasites"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJohn Harty (University of Iowa, USA)
"Immune Regulation During Blood-Stage Plasmodium-Infection"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amLeann Tilley (University of Melbourne, Australia)
"Mechanisms of Action of and Resistance to Artemisinins"
11:00 am - 11:05 amDiscussion
11:05 am - 11:25 amWai-Hong Tham (Walter and Eliza Hall Institute of Medical Research, Australia)
"A New Invasion Pathway for Plasmodium vivax Entry into Reticulocytes"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Tania de Koning-Ward (Deakin University, Australia)
"Is HSP101 the PTEX Unfoldase?"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Mohammad Mahmood Alam (Wellcome Centre for Molecular Parasitology, University of Glasgow, United Kingdom)
"Phospho-Signalling Pathways in Malaria Parasite During Host Cell Invasion"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJacquin Niles (Massachusetts Institute of Technology, USA)
"A Functional Genetics Toolkit for Human Malarial Parasites"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBlood Stage Malaria Biology Moved Forward
Discussion Leader: Wai-Hong Tham (Walter and Eliza Hall Institute of Medical Research, Australia)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmGalit Alter (Ragon Institute, Harvard Medical School, USA)
"Using Systems Tools to Define Correlates of Humoral Immunity Against Malaria"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmBrendan Crabb (Burnet Institute, Australia)
"Toward Anti-Malarial Drugs Targeting Host Red Blood Cell Remodelling"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmSelected from Poster Abstracts: Christine Lehmann (The Francis Crick Institute, United Kingdom)
"Plasmodium falciparum Dipeptidyl Aminopeptidase 3 Is Important for Efficient Attachment of Merozoites to Erythrocytes"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmSimon Draper (Jenner Institute, University of Oxford, United Kingdom)
"Towards a Broadly-Neutralising Vaccine Against the P. falciparum Merozoite"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmEmerging Themes in Pathogenesis and Host Defense
Discussion Leader: Peter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amBenjamin Marsland (University Hospital of Lausanne, Switzerland)
"Microbiota and Respiratory Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amNathan Schmidt (University of Louisville, USA)
"Contributions of the Intestinal Microbiota to Severe Malaria"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amMiguel Soares (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciencia, Portugal)
"Disease Tolerance as a Defence Strategy Against Malaria"
11:00 am - 11:10 amDiscussion
11:10 am - 11:20 amSelected from Poster Abstracts: Caroline Junqueira (Instituto René Rachou, Fiocruz Minas, Brazil)
"The Role of Antigen-Presenting Reticulocytes During Malaria"
11:20 am - 11:25 amDiscussion
11:25 am - 11:35 amSelected from Poster Abstracts: Vanessa Zuzarte-Luis (University of Lisbon, Portugal)
"Dietary Alterations Modulate the Establishment of Plasmodium Infection"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amSelected from Poster Abstracts: Lisa Drewry (Washington University, USA)
"Toxoplasma gondii Infection Reprograms Monocyte Motility to Favor Migration Within 3D Substrates, Suggesting a Role in Enabling Tissue Dissemination"
11:50 am - 11:55 amDiscussion
11:55 am - 12:15 pmCevayir Coban (Osaka University, Japan)
"Plasmodium Products Persist in the Bone Marrow and Promote Chronic Bone Loss"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmEnabling Tools for Malaria Research
Discussion Leader: Oliver Billker (Wellcome Trust Sanger Institute, United Kingdom)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmUlrike Endesfelder (Max Planck Institute for Terrestrial Microbiology / SYNMIKRO Center for Synthetic Microbiology, Germany)
"From Single Molecules to Life: Quantitative Microscopy at the Nanoscale"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmKirsten Hanson (University of Texas at San Antonio, USA)
"Single Cell Profiling of Plasmodium Phenotypic Heterogeneity"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmSelected from Poster Abstracts: Nil Gural (Massachusetts Institute of Technology, USA)
"How Bioengineering Can Help Us?"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Christopher Goodman (University of Melbourne, Australia)
"Using the Unusual Reproductive Genetics of Plasmodium to Facilitate Phenotypic Analysis in the Parasite Liver Stages"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSelected from Poster Abstracts: David Wright (Vanderbilt University, USA)
"Brain-on-a-Chip: New Tools to Study Cerebral Malaria"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmGeneral Discussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1R13AI134001 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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