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High Throughput Chemistry & Chemical Biology
Gordon Research Conference

New Modalities, Methods and Mechanisms for Chemical Biology

Dates

June 25-30, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chair:
Andrew J. Phillips

Vice Chair:
Ivan Cornella-Taracido

Application Deadline

Applications for this meeting must be submitted by May 28, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Dear Colleagues

The 2017 High-Throughput Chemistry and Chemical Biology (HTCCB) Gordon Research Conference, carries forward the torch of cutting-edge science at the ever-evolving interface of chemistry and chemical biology. The 2017 edition will be held at the Proctor Academy in Andover, NH and will gather invited speakers and attendees from industry, academia and other research institutions for collegial and dynamic discussions of the latest methods, modalities, and mechanisms from chemistry and their use to impact chemistry, chemical biology, and medicine. Afternoon poster sessions will also contribute to the scientific and social exchange at the HTCCB GRC and all conferees are encouraged to participate through the presentation of a poster.

Betsy Parkinson (University of Illinois at Urbana-Champaign) and Cynthia Chio (University of California, San Francisco) are organizing the 5th Gordon Research Seminar (GRS) on High-Throughput Chemistry and Chemical Biology. This GRS will be held on Saturday and Sunday June 13-14, immediately prior to the GRC and will provide an opportunity for trainees to share science and interact with leading researchers in an intimate setting. Graduate students and post-docs are encouraged to apply to both the GRS and GRC.

We invite you to apply to what we expect will be an exciting, stimulating, and memorable meeting.

Andy Phillips, C4 Therapeutics and Ivan Cornella-Taracido, Merck and Co.
Chair and Vice-Chair, 2017 GRC on High-Throughput Chemistry and Chemical Biology

Related Meeting

This GRC will be held in conjunction with the "High Throughput Chemistry & Chemical Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Vanguard of Chemical Biology
Discussion Leader: Jennifer Prescher (University of California, Irvine, USA)
7:40 pm - 8:15 pmDirk Trauner (New York University, USA / University of Munich, Germany)
"Optical Control of the Cytoskeleton"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmRandy Peterson (Massachusetts General Hospital / Harvard University, USA)
"Behavior-Based Discovery of New Optochemical Genetic Tools"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmSteve Haggarty (Massachusetts General Hospital / Harvard University, USA)
"Probing Neurogenetic Disorders Using Patient-Specific Stem Cells and Chemogenomics"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSmall Molecule Probes and Drug Candidates
Discussion Leader: Betsy Parkinson (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:30 amAngela Koehler (Massachusetts Institute of Technology, USA)
"Chemical Probe Discovery for Transcription Factors"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amRichard Sparks (Incyte, USA)
"Fragment to Pharmacophore to Candidate: Invention of INCB054329, a Potent and Selective BRD Inhibitor in Clinical Trials for Oncology"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amAnna Mapp (University of Michigan, USA)
"Small Molecule Modulators of Conformationally Dynamic Protein Complexes"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amJonathan Morris (University of New South Wales, Australia)
"Developing Small Molecule Inhibitors of RNA Splicing Kinases for the Modulation of Protein Isoforms"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology with Proteins, Mini-Proteins, and Peptides
Discussion Leader: Joshua Kritzer (Tufts University, USA)
7:30 pm - 8:05 pmAlbert Bowers (UNC Eshelman School of Pharmacy, USA)
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmBrad Pentelute (Massachusetts Institute of Technology, USA)
"Homogenous Antibody Drug Conjugates Enabled by Cysteine Arylation"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmAlan Saghatelian (Salk Institute for Biological Studies, USA)
"Discovery and Characterization of Novel Microproteins"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNovel Chemistries and Methods for Chemical Biology and Therapeutics
Discussion Leader: Aaron Wright (Pacific Northwest National Laboratory, USA)
9:00 am - 9:30 amYimon Aye (Cornell University / Weill Cornell Medicine, USA)
"'Stay on Target' — Targeting Kinetically Privileged First Responders in Electrophile Signaling"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amMarcus Bantscheff (Cellzome / GlaxoSmithKline, Germany)
"Comprehensive Drug Target Profiling Using Complementary (Chemo-)proteomics Approaches"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCorey Nislow (Genetic Networks, USA)
"The Cellular Response to Drugs Quantified by Fitness Profiling: A Genetic Networks' Perspective"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amEmily Parker (University of Canterbury, New Zealand)
"Unravelling and (Re)engineering Biosynthetic Pathways"
11:50 am - 11:55 amDiscussion
11:55 am - 12:25 pmJennifer Prescher (University of California, Irvine, USA)
"Spying on Cellular Communication"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology: Phenotype, Target Engagement, and Mechanism of Action
Discussion Leader: Cynthia Chio (University of California, San Francisco, USA)
7:30 pm - 8:05 pmStewart Fisher (C4 Therapeutics, Inc., USA)
"It's About Time: Mechanistic PK-PD Models for Time-Dependent Inhibitors"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmLyn Jones (Pfizer, USA)
"Drug-Target Engagement in Live Cells"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmChristopher Vakoc (Cold Spring Harbor Laboratory, USA)
"Generating Resistance Alleles of Epigenetic Drug Targets"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Chemistries and Methods for Chemical Biology and High-Throughput Experimentation
Discussion Leader: Samuel Gerritz (Bristol-Myers Squibb, USA)
9:00 am - 9:30 amStevan Djuric (AbbVie, USA)
"Enabling Chemistry Technologies - Accelerators of Drug Discovery"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amAlexander Satz (Roche, Switzerland)
"Design and Application of DNA Encoded Libraries at Roche"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amMelodie Christensen (Merck Research Laboratories, USA)
"High Throughput Experimentation in the Optimization of Metallaphotoredox Catalyzed Alpha-Hydroxy Arylation Reactions"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amAleksandra Baranczak (AbbVie, USA)
"Comparison of Methods for Determination of Drug-Target Engagement Studies in Live Cells"
11:50 am - 11:55 amDiscussion
11:55 am - 12:25 pmLate-Breaking Topic
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChemistry and Biology of Natural Products
Discussion Leader: Tarek Sammakia (University of Colorado Boulder, USA)
7:30 pm - 8:05 pmCorinna Schindler (University of Michigan, USA)
"New Methods for the Synthesis of Biologically Active Molecules"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmMichael Burkart (University of California, San Diego, USA)
"Directing Biosynthesis Through Protein-Protein Interactions"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmCorey Stephenson (University of Michigan, USA)
"Redox Catalysis for Complex Molecule Synthesis"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBivalent Molecules and Other Novel Approaches to Control of Function
Discussion Leader: Lyn Jones (Pfizer, USA)
9:00 am - 9:30 amRaymond Chen (AstraZeneca R&D Boston, USA)
"Clinical Candidate AZD5153 Is a Novel Bivalent Inhibitor of BET Bromodomains"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amRhamy Zeid (C4 Therapeutics, USA)
"Targeted Protein Degradation as a Novel Therapeutic Approach"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amDavid Spiegel (Yale University, USA)
"Bifunctional Molecules for Modulating Human Immune Responses"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amLate-Breaking Topic
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Novel Therapeutics
Discussion Leader: Alan Saghatelian (Salk Institute for Biological Studies, USA)
7:30 pm - 8:05 pmPhil Chamberlain (Celgene, USA)
"Expanding the Druggable Genome with Cereblon Modulators"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmDaria Hazuda (Merck Research Laboratories, USA)
"Novel Approaches to Infectious Disease Targets"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmNathanael Gray (Dana Farber Cancer Institute, USA)
"Targeting Transcription Addiction in Cancer"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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