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Oxidative Stress and Disease
Gordon Research Conference

The Redox Biology of Age-Related Diseases

Dates

March 1-6, 2015

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Deborah A. Ferrington & Rajiv Ratan

Vice Chairs:
LaDora V. Thompson & Giuseppe Poli

Meeting Description

The 2015 GRC on Oxidative Stress and Disease: "The Redox Biology of Age-Related Disease", is focused on examining how changes in redox signaling trigger and participate in age-related diseases. The emerging role of redox signaling dyshomeostasis is gaining support in the fields of aging and age-related disease (i.e., diabetes, ocular dysfunction, stroke) and challenges the current paradigm that damage by reactive oxygen and nitrogen species to macromolecules is the primary pathologic event that drives the aging phenotype. Since redox signaling is an important part of normal physiology, strategies must be identified that permit pathological redox signaling to be reduced while maintaining or augmenting physiological redox signals. The conference emphasis will be on the explosive new developments in the field in terms of central principles of redox biology, including redox-based mechanisms of cell signaling; contributions of redox enzymes NADPH oxidase and nitric oxide synthase, and the newly described jumanji demethylases, HIF prolyl hydroxylases and MICAL proteins; the pathologic consequences of redox imbalance; cutting-edge technology that permits improved resolution of cellular redox events; and novel redox-targeted therapeutics for treating disease.

The program draws from a diverse field of well-established and "emerging" scientists and clinicians from across the globe who are at the forefront of their field. The collegial atmosphere, with extended discussion during the program as well as ample opportunities for more casual interactions during poster session, meals, and evening social times, will promote "cross-pollination" of ideas among researchers in different disciplines. Young investigators will have the opportunity to present their work in poster format, with some poster presenters selected for short talks that are integrated into the scientific program.

Related Meeting

This GRC was held in conjunction with the "Oxidative Stress and Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Changing Concepts in Redox Biology
Discussion Leaders: Deborah Ferrington (University of Minnesota, USA) and Rajiv Ratan (Burke Medical Research Institute / Cornell University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmDean Jones (Emory University, USA)
"Redox Systems Biology: Quest for Central Theory"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmSue Goo Rhee (Yonsei University College of Medicine, South Korea)
"Intracellular Messenger Function of H2O2 Molecules Released from the Mitochondria"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRedox Chemistry and Signaling
Discussion Leader: Enrique Cadenas (University of Southern California, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amChristine Winterbourn (University of Otago Christchurch, New Zealand)
"Peroxiredoxin 2 Interactions and Regulation of Redox Signaling"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amAlicia Kowaltowski (Universidade de Sao Paulo, Brazil)
"Cardiolipin Participates in the Maintenance and Stability of mtDNA"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amHelen Griffiths (Aston University, United Kingdom)
"Metabolism, Glutathione, and Inflammageing"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pmKelvin Davies (University of Southern California, USA)
"Compromised Inducibility of Proteasome, Immunoproteasome, and the Lon Protease via the Nrf2 and IRF Signal Transduction Pathway in Aging"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTechniques to Measure In Vivo Redox Status
Discussion Leader: Holly Van Remmen (Oklahoma Medical Research Foundation, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmVsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russia)
"Novel Tools and Directions in Redox Imaging"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmMike Murphy (MRC - Mitochondrial BIology Unit, United Kingdom)
"The Roles and Assessment of Mito ROS in Pathology"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Yimon Aye (Cornell University / Weill Cornell Medical College, USA)
"Deconvoluting Redox Biology with Targeted Chemistry"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAltered Redox and Age-Related Eye Disease
Discussion Leader: M. Cristina Kenney (University of California, Irvine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amHazel Szeto (Weill Cornell Medical College, USA)
"Bendavia: The First Cardiolipin-Targeted Therapeutic That Promotes Mitochondrial Bioenergetics and Reduces ROS Production"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amKai Kaarniranta (University of Eastern Finland / Kuopio University, Finland)
"Crosstalk of Oxidative Stress, Redox Signaling and Autophagy in the Pathogenesis of Age-Related Macular Degeneration"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amUla Jurkunas (Schepens Eye Research Institute, USA)
"DNA Damage in the Pathogenesis of Fuch's Corneal Dystrophy"
11:25 am - 11:40 amDiscussion
11:40 am - 12:10 pmKazuo Tsubota (Keio University School of Medicine, Japan)
"Oxidative Stress and Dry Eye"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm"Omics" and Redox Stress
Discussion Leader: Vadim Gladyshev (Harvard Medical School, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmChristine Vogel (New York University, USA)
"A Novel Role for Redox-Sensitive Linkage-Specific Protein Polyubiquitination"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmBing Zhang (Vanderbilt University School of Medicine, USA)
"A Systems Approach to Relating Protein Adduction to Gene Expression Changes"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Zhigang Liu (University of Southern California, USA)
"Effect of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRedox Regulation, Stem Cells, and Age-Related Disease
Discussion Leader: Margot Mayer-Proschel (University of Rochester Medical Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:25 amRodney Levine (National Institutes of Health, USA)
"An Historical Interlude: Earl Stadtman's Linkage of Redox Biology and Aging"
9:25 am - 9:30 amDiscussion
9:30 am - 9:45 amSelected from Poster Abstracts: Charles Hoeffer (University of Colorado, Boulder, USA)
"Isoform Specific Overexpression of Regulator of Calcineurin1 (RCAN1) Is Involved in Mitochondrial-Mediated Neurodegeneration Involved in Alzheimer's Disease"
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amSaghi Ghaffari (Icahn School of Medicine at Mount Sinai, USA)
"Stem Cells, Oxygen Metabolism and Disorders of Aging: An Interactive Network"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amSimone Di Giovanni (Imperial College London, United Kingdom)
"Nox2-Dependent Signaling Is Essential for Axonal Outgrowth and Regeneration After Nerve Injury"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMark Noble (University of Rochester, USA)
"The Redox/Fyn/c-Cbl Pathway Is a Critical Regulator of Normal and Pathological Cell Function"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNovel Oxidases and Disease
Discussion Leader: Michael Tymianski (University of Toronto, Canada)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmKarl-Heinz Krause (University of Geneva, Switzerland)
"NOX Family NADPH Oxidases and Human Disease"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmJohanna Myllyharju (University of Oulu, Finland)
"HIF Prolyl Hydroxylases: From Bench to Bedside"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmChristopher Schofield (University of Oxford, United Kingdom)
"Roles of Oxygenases in Hypoxia Sensing"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRedox Regulation as a Therapeutic Strategy
Discussion Leader: John Ash (University of Florida, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amAlfredo Sadun (Doheny Eye Institute / UCLA, USA)
"Treatment Results with the Novel Quinone, EPI 743, for Leber's Heredity Optic Neuropathy"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amPinchas Cohen (University of Southern California, USA)
"Mitochondrial-Derived Peptides in Aging and Age-Related Diseases"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amStuart Lipton (Sanford-Burnham Medical Research Institute, USA)
"Use of iPS-Derived Neurons to Study Redox-Regulated Targets and Therapeutics: S-Nitrosylation of Transcription Factor MEF2 in an Isogenic Human iPSC Model of Parkinson's Disease"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pmJohn Ash (University of Florida, USA)
"Stimulating Mitochondrial Biogenesis to Increase Resistance to Oxidative Stress and Promote Neuroprotection"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmClosing Remarks
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFunctional Regulation Through Site-Specific Oxidation by MICAL
Discussion Leader: Rodney Levine (National Institutes of Health, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmJonathan Terman (University of Texas Southwestern Medical Center, USA)
"Reversible Redox Regulation of Actin Dynamics to Control Neural Development"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMark Lundquist (Weill Cornell Medical College, USA)
"Mical2 and Transcriptional Regulation of Growth Factor Signalling"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmSelected from Poster Abstracts: Collin Ewald (Joslin Diabetes Center / Harvard Medical School, USA)
"Importance of Extracellular Matrix Remodeling for Longevity and Oxidative Stress Resistance in C. elegans"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by R13 AG049527 from the National Institute on Aging, the National Eye Institute and the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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