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Tuberculosis Drug Discovery & Development
Gordon Research Conference

New Approaches, New Chemical Entities and New Targets for Tuberculosis Drugs

Dates

June 25-30, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy Site Information

Organizers

Chairs:
Courtney C. Aldrich & Tanya Parish

Vice Chairs:
Lluis Ballell-Pages & Helena I. Boshoff

Application Deadline

Applications for this meeting must be submitted by May 28, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Conference on Tuberculosis Drug Discovery and Development will explore the entire process of drug discovery from clinical development of new drugs for tuberculosis (TB) to the underlying biology of Mycobacterium tuberculosis that impacts drug discovery efforts. The conference will address the unique challenges in TB drug discovery through discussion of clinical trial design, complimentary approaches to identification of lead compounds, vulnerable targets and pathways, host-directed therapies, and non-traditional approaches to TB prevention and treatment. We invite researchers interested in all aspects of drug discovery and development and welcome participants from academia, industry, government and non-governmental organizations. In particular, we invite trainees and scientists from TB-endemic countries to apply, as their contribution to the struggle against TB is especially important. All participants are asked to submit abstracts of their work for presentation as posters, and some abstracts will be chosen for oral presentations. The conference provides the opportunity to interact with colleagues in an informal and intimate atmosphere and is designed to promote extensive discussion. In the past, the meeting has been oversubscribed – please apply early!

Related Meeting

This GRC will be held in conjunction with the "Tuberculosis Drug Discovery & Development" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Need for New Drugs Against Tuberculosis
Discussion Leader: Tanya Parish (Infectious Disease Research Institute, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:00 pmIntroduction by Discussion Leader
8:00 pm - 8:40 pmGraeme Meintjes (University of Cape Town, South Africa)
"New Drugs for TB: Clinical and Programmatic Needs and Challenges"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmValerie Mizrahi (Institute of Infectious Disease and Molecular Medicine, South Africa)
"Harnessing Biological Insight to Accelerate TB Drug Discovery"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChallenges in Clinical Trials and Biomarkers for Tuberculosis
Discussion Leader: Anna Upton (TB Alliance, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBruce Thomas (The Arcady Group, USA)
"New Facts Regarding, and Novel Approaches to, TB Treatment Adherence: Implications for Clinical Practice and Drug Development"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amGerhard Walzl (Stellenbosch University, South Africa)
"Developing Treatment Response Biomarkers"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amDebra Hanna (Critical Path Institute, USA)
"Critical Path to TB Drug Regimens: Integrating Data to Drive Innovation in Translational Science for TB Drug Regimen Development"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amGerry Davies (University of Liverpool, United Kingdom)
"PreDiCT-TB: Learning from Preclinical Data"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmRada Savic (University of California, San Fransisco, USA)
"One Treatment Regimen Does Not Fit All - Use of Data Science to Guide TB Patient Stratification"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmLead Optimization and Clinical Evaluation
Discussion Leader: Lluis Ballell-Pages (GlaxoSmithKline, Spain)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmNader Fotouhi (TB Alliance, USA)
"Towards Safer Oxazolidinones as Components of Universal Regimens for TB"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmVadim Makarov (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Russia)
"Clinical Trials with the Novel Drug Candidate PBTZ169"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:40 pmDavid Barros (GlaxoSmithKline R&D, Spain)
"New Clinical Candidates for TB Treatment"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmHit-to-Lead Optimization and Pharmacokinetics in Early Drug Discovery
Discussion Leader: Kelly Chibale (Institute of Infectious Disease and Molecular Medicine, South Africa)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amJeffrey Aube (University of North Carolina at Chapel Hill, USA)
"Seeking TB-Active Cephalosporins"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amSylvie Garneau-Tsodikova (University of Kentucky, USA)
"Novel Aminoglycoside Adjuvants and Stand-Alone Agents to Combat Tuberculosis"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amJason Sello (Brown University, USA)
"Beyond the Conventional: Novel Molecules and Strategies for the Treatment of Tuberculosis"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amLate-Breaking Topic
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNatural Products in Antibacterial Discovery
Discussion Leader: Ronald Quinn (Griffith University, Australia)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmSean Brady (Rockefeller University, USA)
"Culture Independent Approaches for the Discovery of New Antibiotics"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmLate-Breaking Topic
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:40 pmNathan Magarvey (McMaster University, Canada)
"Clustering and Assembly of Genetically Inferred Antibiotics"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetabolism as a Target
Discussion Leader: Luiz Pedro Carvalho (Francis Crick Institute, United Kingdom)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amLaura Kiessling (University of Wisconsin-Madison, USA)
"Chemical Probes of Cell Envelope Biosynthesis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amLindsay Eltis (University of British Columbia, Canada)
"Cholesterol Catabolism - A Ring-Side Seat"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amAnthony Baughn (University of Minnesota, USA)
"Stress Response as a Driver of Pyrazinamide Susceptibility"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amNagasuma Chandra (Indian Institute of Science, India)
"Reversing Antibiotic Resistance Through Strategic Combinations"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPromiscuous Targets, Drugs, and Hits
Discussion Leader: Kevin Pethe (Lee Kong Chian School of Medicine, Nanyang Technologicial University, Singapore)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmJonathan Baell (Monash University, Australia)
"Resource-Wasting Pan Assay Interference Compounds (PAINS): Readily Found in Any Screen and Highly Relevant to TB Drug Discovery"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:50 pmShort Talk Selected from Poster Abstracts
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:20 pmAdrie Steyn (Kwazulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), South Africa)
"Bioenergetic Rewiring: Turning the Respiratory Flexibility of M. tuberculosis Against Itself"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmMary Jackson (Colorado State University, USA)
"MmpL3: Therapeutic Potential and Mechanism of Inhibition"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmHost-Directed Therapies and Host-Pathogen Interactions
Discussion Leader: Gilla Kaplan (Bill & Melinda Gates Foundation, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amPriscille Brodin (Institut Pasteur de Lille, France)
"Investigation of a Drug Candidate with Enhanced Potency Against Intracellular M. tuberculosis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amRobert Abramovitch (Michigan State University, USA)
"Small Molecules that Inhibit Mycobacterium tuberculosis Environmental Sensing and Virulence"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amShort Talk Selected from Poster Abstracts
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amLate-Breaking Topic
11:35 am - 11:45 amDiscussion
11:45 am - 12:10 pmThomas Hawn (University of Washington, USA)
"Host-Directed Therapies in Macrophages and TB"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmOutside the Norm: Non-Traditional Approaches
Discussion Leader: Helena Boshoff (National Institutes of Health, USA)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmLate-Breaking Topic
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmNitin Baliga (Institute for Systems Biology, USA)
"Network Strategy to Accelerate Discovery of Combination Therapy Against Drug Resistance in TB"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:40 pmGiulia Manina (Institut Pasteur, France)
"Targeting Phenotypic Variation in Mycobacteria to Improve Drug-Mediated Killing"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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