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IGF and Insulin System in Physiology and Disease
Gordon Research Conference

The IGFs and Insulin System: Emerging Themes in Aging, Diabetes, Cancer and Other Diseases

Dates

March 8-13, 2015

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Briony E. Forbes

Vice Chair:
Cunming Duan

Meeting Description

The 2015 Gordon Conference on the Insulin like Growth Factor (IGF) and insulin system in Physiology and Disease will present cutting-edge research on the role of IGFs and insulin and their signaling pathways in normal growth, development, metabolism and in major diseases. IGFs have essential functions as local mediators of cell proliferation, survival, differentiation, metabolism and migration. Through these actions the system plays important roles in processes such as cardiovascular, brain, muscle and bone development. The IGF and insulin system is also implicated in ageing, neurodegeneration, Alzheimers’, diabetes and cancer progression. New therapeutic interventions for these conditions are actively being developed through investigation of this system. This Conference will cover the physiological and molecular aspects of IGFs and insulin, receptors, binding proteins and signaling pathways in stress and ageing, neurogenesis and neurodegeneration, cancer progression, somatic cell growth and stem cells. The goal of the Conference is to bring together investigators who are at the forefront of their field to discuss the key aspects of the IGF and insulin system in different tissues and diseases. It will provide opportunities for junior scientists and graduate students to present their work and exchange ideas with leaders in the field. Abstracts will be selected for presentation as short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings will provide an avenue for scientists from different disciplines to brainstorm and promote collaborations ultimately aimed at understanding and potentially manipulating IGF and insulin functions to enhance normal tissue function or to suppress disease progression.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmIGF and Insulin System in Aging
Discussion Leader: Cunming Duan (University of Michigan, USA)
7:40 pm - 8:40 pmAndrzej Bartke (Southern Illinois University, USA)
"Somatotropic Axis and Aging: Surprising Benefits of Endocrine Defects"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAging
Discussion Leader: Marc Tatar (Brown University, USA)
9:00 am - 9:25 amNir Barzilai (Albert Einstein College of Medicine, USA)
"Role of the GH/IGF1 Axis in Exceptional Longevity"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amYousin Suh (Albert Einstein College of Medicine, USA)
"Functional Genomics of Aging"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amColeen Murphy (Princeton University, USA)
"Insulin Signaling in the Regulation of Age-Related Declines"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amMartin Holzenberger (INSERM UMRS 938, France)
"IGF-1R Signaling in Aging and Age-Related Disease"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Simon Johnson (Albert Einstein College of Medicine, USA)
"Genetic variation in Insulin/IGF1/mTOR genes modulates human lifespan"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Albert Chen (University of Michigan Medical School, USA)
"Hierarchical Action of DAF-16/FoxO Isoforms in Life Span Control"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Mechanisms Underlying IGF and Insulin Action
Discussion Leader: Pierre De Meyts (De Meyts R&D Consulting, Belgium)
7:30 pm - 7:55 pmMichael Lawrence (Walter and Eliza Hall Institute, Australia)
"New Insights Into the Way in Which Insulin Engages its Receptor - An Unfolding Story"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmDaniel Leahy (Johns Hopkins University School of Medicine, USA)
"Molecular Mechanisms Governing IGF1R Activity"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Julian Weghuber (Upper Austria University of Applied Science, Austria)
"Analysis of Insulin Receptor Substrate (IRS) Signaling Dynamics on Micro-Structured Surfaces"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Lenka Zakova (Institute of Organic Chemistry and Biochemistry, Czech Republic)
"Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the β-Chain in Human Insulin"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIGF and Insulin Signaling in Growth, Metabolism and Disease
Discussion Leader: Antonino Belfiore (University of Catanzaro, Italy)
9:00 am - 9:25 amAndreas Hoeflich (Institute for Genome Biology, Germany)
"IGF System, Metabolism and Diabetes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amNorbert Tennagels (Sanofi Diabetes, Germany)
"Metabolic and Mitogenic Signaling of Insulin Analogs"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amShoshana Yakar (New York University College of Dentistry, USA)
"GH/IGF Axis in Bone: New Discoveries"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amSelected from Poster Abstracts: Buel Rodgers (Washington State University, USA)
"Revising a 43 Year Old Model of Vertebrate Growth Control Through the Novel Actions of Myostatin"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmFriedrich Metzger (F. Hoffmann-La Roche Ltd., Switzerland)
"The Therapeutic Potential for PEG-IGF-I in Spinal Muscular Atrophy with Respiratory Distress Type 1"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Wenbiao Chen (Vanderbilt University School of Medicine, USA)
"Modeling Type 2 Diabetes in Zebrafish with Insulin Resistance and Overnutrition"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIGF-II and the IGF2R
Discussion Leader: Bass Hassan (University of Oxford, United Kingdom)
7:30 pm - 7:55 pmAndrew Hoffman (Stanford University, USA)
"Long Noncoding RNAs, Looping and the IGF System"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmSelected from Poster Abstracts: Susana Frago (University of Oxford, United Kingdom)
"Evolution of an IGF2-TRAP"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmSteven Levison (Rutgers University, New Jersey Medical School, USA)
"IGF-II Is an Adult Intestinal Stem Cell Niche Factor"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Wei Ge (The University of Macau, Macau SAR China)
"IGF Regulation of Y-Box Binding Protein 1 (YB-1; Ybx1) in the Ovary: A Potential Mechanism of How the Growth Axis Influences Ovarian Follicle Activation"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIGFs and Insulin in Cancer
Discussion Leader: Stephen Hursting (University of North Carolina, USA)
9:00 am - 9:25 amDouglas Yee (Masonic Cancer Center, University of Minnesota, USA)
"Have We Learned Anything by Targeting IGF-IR in Cancer?"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amKatia Scotlandi (Rizzoli Institute, Italy)
"ERG Transcriptional Factor Activity in Prostate and Ewing Sarcoma and Effect on IGF-1R Expression"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amBo Hansen (Novo Nordisk, Denmark)
"Insulin Analogues – Molecular Difference from Human Insulin – a Cause for Concern?"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amDerek Leroith (Mount Sinai School of Medicine, USA)
"The Importance of the Insulin/IGF-1 Receptors in Obesity-Related Cancer Risk"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Rita Nahta (Emory University, USA)
"Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of HER2-Overexpressing Breast Cancer Cells via Modulation of FoxM1"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Zhen Tang (University of Bristol, United Kingdom)
"Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) Inhibits Growth, Invasion and Colony Formation of Bladder Cancer Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmIGF Binding Proteins
Discussion Leader: Robert Baxter (Kolling Institute of Medical Research, Australia)
7:30 pm - 7:50 pmJanet Martin (University of Sydney, Australia)
"Targeting IGFBP-3 Signaling Pathways as a Novel Therapy for Triple-Negative Breast Cancers"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMaria Grant (Indiana University, USA)
"IGFs, IGFBPs and Diabetic Microvascular Complications"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAbhishek Kashyap (Queensland University of Technology, Australia)
"Novel Approaches Targeting the IGF/Vitronectin/Integrin Axis in Cancer Progression: Proof-of-Concept Evidence"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSelected from Poster Abstracts: Malene Jepsen (Aarhus University, Denmark)
"Stanniocalcin-2 Is a Novel Proteinase Inhibitor Regulating Mammalian Growth by Proteolytic Inhibition of the Insulin-Like Growth Factor Axis"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurological Diseases/Stem Cells/Progenitor Cells
Discussion Leader: Teresa Wood (Rutgers University, New Jersey Medical School, USA)
9:00 am - 9:25 amPaula Moreira (University of Coimbra, Portugal)
"Insulin Signaling as a Bridge Between Diabetes and Alzheimer's Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amCora O'Neil (University College Cork, Ireland)
"Insulin and IGF Signaling in Alzheimer’s Disease"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 10:55 amSelected from Poster Abstracts: Heidemarie Kletzl (Hoffmann La Roche, Switzerland)
"Pharmacokinetics, Pharmacodynamics, and Safety and Tolerability of a Novel Pegylated rhIGF-1 in Humans"
10:55 am - 11:05 amDiscussion
11:05 am - 11:20 amSelected from Poster Abstracts: Bhumsoo Kim (University of Michigan, USA)
"Beneficial Effect of IGF-I on Insulin Resistance-Induced Increases in Amyloid Precursor Protein and Tau Phosphorylation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSelected from Poster Abstracts: Rudiger Schulz (Utrecht University, The Netherlands)
"Igf3 Mediates Stimulatory Effects of Fsh on Spermatogenesis in Zebrafish"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSelected from Poster Abstracts: Zoltan Ungvari (University of Oklahoma, ROCA, USA)
"IGF-1 Deficiency Impairs Neurovascular Coupling in Mice: Implications for Cerebromicrovascular Aging"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIGF-1R and IR Signalling Pathways
Discussion Leader: Shin-Ichiro Takahashi (University of Tokyo, Japan)
7:30 pm - 7:50 pmSelected from Poster Abstracts: Gang Xi (University of North Carolina, Chapel Hill, USA)
"Tissue Specific Knockout Reveals that IRS-1 but not IRS-2 Regulates Vascular Smooth Muscle Cell Differentiation and Loss of IRS-1 Results in a Marked Increase in Proliferation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSelected from Poster Abstracts: Yosuke Yoneyama (University of Tokyo, Japan)
"IRS-1 is a Negative Feedback Regulator of IGF-I Receptor Internalization via Interaction with AP-2 Clathrin Adaptor Complex"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSelected from Poster Abstracts: Barbara Addario (University College Cork, Ireland)
"IGF-1R-associated protein complexes in cancer phenotype (EMT) and therapy resistance"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLinheng Li (Stowers Institute for Medical Research, USA)
"Epigenetic Regulation of Igf2/Igfr Signaling Through Imprinting"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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