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Cardiac Arrhythmia Mechanisms
Gordon Research Conference

The Surprising Heart: A Hetero-Cellular, Multi-Physics, and Inter-Disciplinary Challenge

Dates

March 22-27, 2015

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Peter Kohl

Vice Chair:
Gail A. Robertson

Meeting Description

The 2015 Gordon Research Conference on Cardiac Arrhythmia Mechanisms will provide a forum in which cutting edge concepts and new observations on mechanisms and treatment of complex cardiac rhythm disturbances are discussed, at levels of integration ranging from molecule to the patient. The meeting will focus on key scientific discoveries, relevant to both basic science and the clinic, emphasizing multi-disciplinary approaches to integrating the latest (and, to a large extent, unpublished) advances in structural biology, genomics, proteomics, stem cell research, cellular and tissue electrophysiology, high-resolution electro-mechanical mapping, and computational modeling to study of the hetero-cellular nature of cardiac arrhythmogenesis and anti-arrhythmic therapy.

This represents an exceptional opportunity for bringing together an internationally leading selection of outstanding investigators who are experts in various relevant fields, including biologists, geneticists, electrophysiologists, biophysicists, biomedical engineers, mathematical biologists, computer scientists, and clinical cardiologists to interact in an informal atmosphere and share ideas about the ‘multi-physics’ nature of mechanisms underlying normal and disturbed heart rhythms, including causes of sudden cardiac death.

Even more so than in previous years will we have an explicit focus on peer interactions with, and mentoring of, trainees and junior investigators, who (for the first time in the Cardiac Arrhythmia Mechanisms GRC history) will have 'their own' 2-day Gordon Research Seminar prior to the GRC.

The Specific Aims of the conference are the following:

  1. To bring together established and young investigators who study the mechanisms of cardiac arrhythmias from interdisciplinary perspectives.
  2. To assess our current understanding of cardiac arrhythmia mechanisms, emphasizing systems approaches which integrate information across multiple scales, from multiple cell types, obtained using a broad range of techniques, to project from gene and molecule to cell, tissue, organ, and organism, including human, using integrated experimental and computational methods.
  3. To highlight neglected areas in our understanding of cardiac arrhythmia mechanisms and to identify and prioritize novel research directions.
  4. To use the critical mass of attendee excellence to improve existing strategies and develop innovative new approaches to treating and preventing cardiac arrhythmias as a leading cause of death in our society.
  5. To bridge the real or perceived divides between levels of investigation, foci of cardiac activity (e.g. electrics and mechanics), employment backgrounds (academia, hospital, industry), geographies, gender, ethnicity or age groups, and thus to consolidate the cardiac arrhythmia research community with the view of enhanced collaboration and, ultimately, success.

Related Meeting

This GRC was held in conjunction with the "Cardiac Arrhythmia Mechanisms" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmRegeneration/Repair and Arrhythmogenesis: Potential and Pitfalls
Discussion Leader: Michael Rosen (Columbia University, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:05 pmLior Gepstein (Technion - Israel Institute of Technology, Israel)
"Reprogramming Mature Cells: Changing Nature or Habits?"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmNicola Smart (University of Oxford, United Kingdom)
"How to Mend a Broken Heart: Make More Muscle"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmJeff Holmes (University of Virginia, USA)
"How to Mend a Broken Heart: Make Better Scars"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPacemaking and Conduction
Discussion Leader: Toon Van Veen (University Medical Center, Utrecht, The Netherlands)
9:00 am - 9:20 amVincent Christoffels (Academic Medical Center, Amsterdam, The Netherlands)
"Gene Regulatory Elements of the Cardiac Conduction System"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amVadim Fedorov (The Ohio State University College of Medicine, USA)
"Nodal Conduction Abnormalities Revealed by Dual-Sided Intramural Optical Mapping"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amPeter Mohler (The Ohio State University College of Medicine, USA)
"TRPM4 and Sinus Node Pacemaking"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amStacey Rentschler (Washington University at St. Louis, USA)
"Reprogramming Strategies for Cardiac Conduction: Yes We Can"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmEugenio Cingolani (Cedars Sinai, USA)
"Using Heart Cells to Fix Cardiac Conduction: We Can, Too"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAtrial Arrhythmias
Discussion Leader: Nathalie Virag (Swiss Federal Institute of Technology, Lausanne, Switzerland)
6:00 pm - 6:10 pmFarhad Pashakhanloo (Johns Hopkins University, USA)
"Novel High-Resolution Image-Based Model of Whole Human Atria with Realistic Subject-Specific Fiber Orientation"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmGuy Salama (University of Pittsburgh, USA)
"Relaxin Suppresses AF by Differential Effects on Fibrosis, Myocytes, and Conduction Velocity: Mechanisms"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:10 pmUli Schotten (Maastricht University, The Netherlands)
"The Role of Fat and Fibrosis in the Domestication of AF"
7:10 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmSanjiv Narayan (Stanford University, USA)
"Mechanistic Therapies for Atrial Fibrillation: Are We Nearly There Yet?"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmVentricular Arrhythmias
Discussion Leader: Magdi Yacoub (Qatar Cardiovascular Research Center, Qatar)
9:00 am - 9:20 amBurkert Pieske (Deutsches Herzzentrum Berlin / Charité Universitätsmedizin Berlin CVK, Germany)
"Ca-Related Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amKatja Odening (Heart Center Freiburg University, Germany)
"LQT: An Electro-Mechanical Disorder"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amBettina Cuneo (University of Colorado School of Medicine, USA)
"In Utero Diagnosis of LQT Syndrome by Magnetocardiography: Possibilities and Limitations"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amPeter Schwartz (IRCCS Istituto Auxologico Italiano, Italy)
"Management of LQT: How to Project from Mouse to Man"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmNatalia Trayanova (Johns Hopkins University, USA)
"The Virtual Electrophysiology Lab: From Pad to Patient"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmUnravelling Arrhythmia Mechanisms: One Channel at a Time (or Two…)
Discussion Leader: Jose Jalife (University of Michigan, USA)
6:00 pm - 6:10 pmPrzemyslaw Radwanski (The Ohio State University, USA)
"A Novel Role for Nav1.6 in Arrhythmogenic Diastolic Ca2+ Release: Neuronal Na+ Channels and the Microdomain Na+/ Ca2+"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmAntonio Zaza (Università Milano-Bicocca, Italy)
"Late Sodium Current (SCN5A/NaV1.5) in Acute Ischemia: Does It Exist and, If So, Does It Matter?"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:10 pmIsabelle Deschenes (Case Western Reserve University, USA)
"SCN5A: Driving Sick Sinus Syndrome and Early Atrial Fibrillation"
7:10 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmConnie Bezzina (Academic Medical Center, Amsterdam, The Netherlands)
"SCN10A and SCN5A: Conspiracy to Cause Brugada"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanics Matters
Discussion Leader: Ursula Ravens (Dresden University of Technology, Germany)
9:00 am - 9:20 amStephane Hatem (INSERM/UPMC, France)
"Shear Stress Effects on Voltage-Sensitive Ion Channel Location: Shifting the Goal Posts"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amAlex Quinn (Dalhousie University, Canada)
"Mechanical Induction of VF: The Concept of a Critical Window in Both Space and Time"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amElisa Konofagou (Columbia University, USA)
"Atrio-Ventricular Electromechanical Wave Imaging: What Can We Learn?"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amPeter Taggart (University College London, United Kingdom)
"Mechanical Modulation of Cardiac Electrophysiology in Patients: So What?"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmSian Harding (Imperial College London, United Kingdom)
"SERCA2a Gene Therapy in Heart Failure: Anti-Arrhythmic Effects of Positive Inotropy"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Nervous Heart
Discussion Leader: James Weiss (David Geffen School of Medicine at UCLA, USA)
6:00 pm - 6:10 pmEmily Ongstad (Clemson University / Virginia Tech Carillon Research Institute, USA)
"A Cx43 CT-Mimetic Peptide Alters Cx43 and Cx43pS368 Heterocellular Interactions in the Injury Border Zone"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmSami Noujaim (Tufts Medical Center, USA)
"Pulmonary Vein Plexi and Pacemaker Function"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:10 pmDominik Linz (University Homburg/Saar, Germany)
"Renal Denervation and Ventricular Arrhythmias: New (Causal?) Links"
7:10 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmCrystal Ripplinger (University of California, Davis, USA)
"Neuronal Effects on Cardiac Source-Sink Relations"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTechniques That (Will) Change the Way We Study and Treat Cardiac Arrhythmia Mechanisms
Discussion Leader: Al George (Northwestern University, USA)
9:00 am - 9:20 amPaul Blainey (The Broad Institute, USA)
"Single Cell Sequencing: Applications, Challenges, Solutions"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amMario Delmar (New York University School of Medicine, USA)
"Visual Proteomics Applied to the Cardiac Connexome: Deciphering Arrhythmia Mechanisms"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amJan Huisken (Max Planck Institute (MPI-CBG), Germany)
"Light Sheet Microscopy of the Heart: Seeing Is Believing"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amMarisa Jaconi (Geneva University, Switzerland)
"Human Stem Cell-Based Three-Dimensional Micro-Tissues for Advanced Cardiac Cell Therapies"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmStefanie Dimmeler (Goethe-University Frankfurt, Germany)
"Vascular MicroRNAs: From Contributors to Heart Disease to Therapeutic Targets"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Surprising Heart: More than Myocytes
Discussion Leader: Gail Robertson (University of Wisconsin, Madison, USA)
6:00 pm - 6:20 pmYoram Rudy (Washington University at St. Louis, USA)
"Multi-Scale Cardiac Electrophysiology: From Single Ion-Channel Molecular Structure to the Human Heart Rhythm"
6:20 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmFilip Swirski (Massachusetts General Hospital / Harvard Medical School, USA)
"Immune Cells and Ventricular Function"
6:55 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmThomas Knopfel (Imperial College London, United Kingdom)
"Cell-Specific Expression of Voltage-Sensitive Proteins: Illuminating Cell Activity and Heterotypic Interactions"
7:30 pm - 7:45 pmDiscussion
7:45 pm - 7:50 pmPeng-Sheng Chen (Krannert Institute of Cardiology, USA)
"The Surprising Heart: Lessons from the 2015 GRC on Cardiac Arrhythmia Mechanisms"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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