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Cell Biology of Metals
Gordon Research Conference

Metals in Physiology and Disease

Dates

July 23-28, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Michael Petris & Roland Lill

Vice Chairs:
Iqbal Hamza & Amanda Bird

Meeting Description

The Gordon Research Conference (GRC) series on "Cell Biology of Metals" provides a truly outstanding forum for scientific exchanges, presentations and discussions in the emerging field of metals in biology, focusing on the acquisition, distribution, sensing and utilization of metals in proteins, cells and systems from bacteria to humans. This conference has now become a cornerstone of the field and is unique in attacking broad research questions such as how metal cofactors are assembled to how metal ions play roles in metabolic and infectious diseases. The 2017 Cell Biology of Metals GRC will be held on July 23-28 at Mount Snow Resort in West Dover, VT. The program is organized around the theme of "Mechanisms from Microbes to Humans". Session topics include metals in enzyme function, metalloenzyme structures, metal homeostasis, metal sensing and dynamics, metalloprotein biogenesis and signaling, metals in host-pathogen interactions and metals in physiology and disease. The conference will be comprised of keynote presentations, research and poster talks, poster discussions, and informal scientific discussions. This meeting will bring together an outstanding and diverse cadre of molecular and structural biologists, biochemists, geneticists, cell biologists, physiologists and clinicians to interact and brainstorm on new discoveries, ideas and directions in basic and applied research on the cell biology of metals. Given the increase in the number of metabolic and infectious diseases linked to changes in cellular metal homeostasis, this meeting fills a critical niche for investigating the underlying mechanism(s) of these disorders and for brainstorming approaches for novel diagnostics, prognostics, and therapeutics.

Related Meeting

This GRC was held in conjunction with the "Cell Biology of Metals" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Metal Homeostasis in Development and Disease
Discussion Leader: Roland Lill (Philipps-Universitaet Marburg, Germany)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmSvetlana Lutsenko (Johns Hopkins University, USA)
"The Role of Copper Homeostasis in Lipid Metabolism"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmRalf Mendel (Braunschweig University of Technology, Germany)
"Molybdenum Metabolism: Pathways, Atomic Structures, Diseases"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetals in Enzyme Function
Discussion Leader: David Giedroc (Indiana University, USA)
9:00 am - 9:25 amNigel Robinson (Durham University, United Kingdom)
"A Cellular Logic for Enzyme Metalation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDaniel Kosman (State University of New York at Buffalo, USA)
"Multicopper Metallo-Oxidases in Cellular Iron and Copper Metabolism"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Clorissa Washington-Hughes (University of South Carolina, USA)
"A Direct Correlation Between Enterobactin Transport and Nickel Resistance in E. coli"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amSelected from Poster Abstracts: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
"You Are What You Don't Eat: Bacterial Adaptation to Nutritional Immunity"
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amVishal Gohil (Texas A&M University, USA)
"New Insights into Mitochondrial Copper Delivery to Cytochrome c Oxidase"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmSabeeha Merchant (University of California, Los Angeles, USA)
"Dynamic Metal Storage in Intracellular Organelles"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kevin Waldron (Newcastle University, United Kingdom)
"Evolutionarily-Driven Cambialism in a Key Metalloenzyme Important During Staphylococcal Infection"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructural Basis of Metalloprotein Function
Discussion Leader: Amy Rosenzweig (Northwestern University, USA)
7:30 pm - 7:55 pmAmie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmHans Christensen (Technical University of Denmark, Denmark)
"The Structure of Dopamine β-Hydroxylase: The Cu Enzyme that Converts Dopamine to Norepinephrine"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmSelected from Poster Abstracts: Oriana Fisher (Northwestern University, USA)
"Characterization of a Unique Copper-Binding Protein from Methanotrophs"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRichard Ortega (Centre National de la Recherche Scientifique (CNRS), France)
"Imaging Bio-Metals in Neurons with X-Ray Nanobeams"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMetal Homeostasis
Discussion Leader: David Eide (University of Wisconsin-Madison, USA)
9:00 am - 9:25 amMitchell Knutson (University of Florida, USA)
"ZIP14 and ZIP8: Novel Players in Manganese Transport and Homeostasis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSomshuvra Mukhopadhyay (The University of Texas at Austin, USA)
"Unexpected Hypothyroidism in Mice Lacking the Manganese Efflux Transporter SLC30A10"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Tom Bartnikas (Brown University, USA)
"Mechanisms of Mammalian Metal Excretion"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amSelected from Poster Abstracts: Ciro Cubillas (Washington University in St. Louis, USA)
"A Genomic Analysis of Zinc-Regulated Transcription in Caenorhabditis elegans"
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amFrederic Barras (Aix Marseille University / CNRS, France)
"Antibiotics and Metals: New Facts to an Old Story"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmUte Kraemer (Ruhr University Bochum, Germany)
"An Integrated Analysis of Metal Hyperaccumulation in Arabidopsis halleri"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Caiyong Chen (Zhejiang University, China)
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetal Sensing and Dynamics
Discussion Leader: Daniela Buccella (New York University, USA)
7:30 pm - 7:55 pmAnkona Datta (Tata Institute of Fundamental Research, India)
"Balancing Selectivity and Cellular Localization: Toward Optimal Sensors for Tracking Mn(II)"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmAmit Reddi (Georgia Institute of Technology, USA)
"Heme Gazing: Probing Heme Trafficking, Signaling, and Dynamics with Fluorescent Sensors and Affinity Reagents"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmJames Imlay (University of Illinois at Urbana-Champaign, USA)
"Molecular Explanations for the Toxicity of Oxygen"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmPatricia Kiley (University of Wisconsin-Madison, USA)
"The Impact of Oxygen on Iron Homeostasis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloprotein Biogenesis and Signaling
Discussion Leader: Frederic Barras (Aix Marseille University / CNRS, France)
9:00 am - 9:25 amAmanda Bird (The Ohio State University, USA)
"Metallation of the Pho8 Alkaline Phosphatase in Fission Yeast"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSimon Labbe (University of Sherbrooke, Canada)
"Spotlight on Schizosaccharomyces pombe Heme Acquisition Proteins"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Sven Freibert (Philipps-Universität Marburg, Germany)
"Structural and Functional Insights into Mitochondrial Fe/S Cluster Synthesis"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amSelected from Poster Abstracts: Byung-Eun Kim (University of Maryland, USA)
"The Ctr1 Cu+ Transporter in Cardiovascular Function and Systemic Copper Signaling"
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amDonita Brady (University of Pennsylvania, USA)
"Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmSilke Leimkuhler (University of Potsdam, Germany)
"The Connection of Molybdenum Cofactor Biosynthesis to Other Cellular Pathways at a Glance"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kurt Warnhoff (Massachusetts General Hospital, USA)
"Interkingdom Transfer of Molybdenum Cofactor from E. coli to C. elegans"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMetals in Host-Pathogen Interactions
Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA)
7:30 pm - 7:55 pmPascal Arnoux (Institute of Biosciences and Biotechnology (BIAM), Aix-Marseille University, France)
"The Old Roots of Nicotianamine: Discovery of Analogs in Pathogenic Bacteria"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmChristopher McDevitt (The University of Adelaide, Australia)
"The Antimicrobial Role of Zinc at the Host-Pathogen Interface"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmDennis Thiele (Duke University School of Medicine, USA)
"How Mammals and Fungal Pathogens Engage in a Tug-of-War over Copper"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmAlejandro Vila (National University of Rosario, Argentina)
"Metallo-Beta-Lactamases: Periplasmic Raiders of the Lost Zinc"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetals in Physiology and Disease
Discussion Leader: Valeria Culotta (Johns Hopkins University, USA)
9:00 am - 9:25 amMarla Berry (University of Hawaii at Manoa, USA)
"Selenium and Sex: Competition Between Brain and Testes for Se Results in Male-Specific Consequences in Mice and Men"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amElizabeth Leibold (University of Utah, USA)
"Iron Deficiency Caused by Loss of Iron-Regulatory Protein 2 Disrupts Mitochondrial Function and Comprises β-Cell Function"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Aslam Khan (University of Missouri, USA)
"A Role for Ceruloplasmin in Innate Immunity"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amSelected from Poster Abstracts: Sarju Patel (National Institutes of Health, USA)
"A Novel Interaction Between Cytosolic Iron Chaperones PCBP1 and BolA2"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amStefano Rivella (Children's Hospital of Philadelphia, USA)
"The Dark Side of Iron in Erythropoiesis"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Daniel Kornitzer (Technion - Israel Institute of Technology, Israel)
"Structure of a Fungal Heme-Iron Acquisition Pathway"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Sargurunathan Subashchandrabose (Wake Forest School of Medicine, USA)
"Protective Role of Copper During Urinary Tract Infection"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Daniela Buccella (New York University, USA)
"Targeted Fluorescent Sensors Reveal Sub-Cellular Mg2+ Dynamics in Cell Death"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Metal Homeostasis from Worms to Mammals
Discussion Leader: Michael Petris (University of Missouri, USA)
7:30 pm - 8:10 pmVadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA)
"Two Hundred Years of Selenium Research"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 9:00 pmIqbal Hamza (University of Maryland, USA)
"Heme Trafficking: Lessons from Bloodless Worms"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK113725-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. government.
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