Gordon Research Conferences
Meeting Details
Search:
  GO

Cilia, Mucus and Mucociliary Interactions
Gordon Research Conference

Advancements in Molecular Understanding and Therapeutic Targeting of Mucociliary Disorders

Dates

February 12-17, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Elizabeth Smith & Heymut Omran

Vice Chairs:
Christopher Evans & Hannah M. Mitchison

Meeting Description

The interaction of cilia and mucus is an essential component of respiratory tract defense against pathogens and when dysfunctional, leads to diseases ranging from the common cold, asthma, rhinosinusitus, chronic obstructive lung disease and genetic diseases cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). The rapid advancement of technologies such as next generation sequencing, high resolution microscopy and the development of novel in vitro analysis systems has led to an exponential growth of knowledge related to the assembly and function of cilia, production and secretion of mucus, and cilia-mucus interaction to promote productive mucociliary clearance. These achievements have paved the way for future development of therapeutic strategies to treat mucociliary clearance disorders. However, significant questions remain that will be addressed in the proposed meeting: (1) What is the molecular basis for the differentiation of ciliated epithelia? 2) How can we analyze the hydrodynamics and biophysical properties of cilia-mucus interactions in healthy and disease states with high resolution? 3) What is the relationship between cilia, mucus and mucosal immunity? And, (4) what diagnostic and therapeutic approaches provide the most effective monitoring and correction of defects? To attempt to fill these gaps, the meeting brings together a distinctive group of investigators for sessions of cutting-edge data, with a mandate for presenting unpublished research in a closed environment. The structure of this GRC provides a highly interactive forum for investigators and trainees.

Related Meeting

This GRC was held in conjunction with the "Cilia, Mucus and Mucociliary Interactions" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Cilia, Mucus and Mucociliary Diseases
Discussion Leaders: Martina Brueckner (Yale University, USA) and David Thornton (University of Manchester, United Kingdom)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmBurton Dickey (University of Texas MD Anderson Cancer Center, USA)
"Airway Mucus Production, Secretion, and Function"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMarcus Mall (Heidelberg University, Germany)
"Airway Mucus in the Pathogenesis and as a Therapeutic Target of Chronic Lung Diseases"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDaniela Nicastro (University of Texas Southwestern Medical Center, USA)
"Cryo-Electron Tomography Reveals How Cilia and Flagella Generate Motility"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDifferentiation, Assembly, and Regulation of Mucociliary Components
Discussion Leaders: Maimoona Zariwala (University of North Carolina at Chapel Hill, USA) and Gaia Pigino (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
9:00 am - 9:20 amMonica Bettencourt-Dias (Calouste Gulbenkian Foundation, Instituto Gulbenkian de Ciencia, Portugal)
"Themes and Variations in Centrosome and Cilia Structure and Function in Development and Evolution"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStephen King (University of Connecticut Health Center, USA)
"A Bioactive Peptide Amidating Enzyme Is Required for Ciliogenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amIvana Yang (University of Colorado Denver, USA)
"Contribution of Cilia to Mucociliary Defects in Pulmonary Fibrosis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amEric Haarmann (VU University Medical Center, The Netherlands)
"The X-Linked Inheritance in PCD: Discovery of a New Causative Gene"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amEmily Hunter (Emory University, USA)
"Ida3 Is a Novel Inner Dynein Arm Assembly Factor that Is Transported by IFT in Growing Cilia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPeter Jackson (Stanford University School of Medicine, USA)
"A New, Highly Conserved GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Martina Brueckner (Yale University, USA) and Cecilia Lo (University of Pittsburgh, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTechnical Advancements to Study Mucociliary Biology
Discussion Leaders: Maureen Wirschell (University of Mississippi Medical Center, USA) and David Erle (University of California, San Francisco, USA)
7:30 pm - 7:50 pmSusan Birket (University of Alabama at Birmingham, USA)
"New Insights Using Functional Anatomic Imaging to Interrogate the Airway Surface"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKatharina Ribbeck (Massachusetts Institute of Technology, USA)
"Probing Microbial Interactions with the Mucus Barrier"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBrad Rosen (University of Iowa Carver College of Medicine, USA)
"Mucoinflammatory Bronchiectasis in Cystic Fibrosis Ferrets Does Not Require Infection"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDavid Hill (University of North Carolina at Chapel Hill, USA)
"Matching Mucus to Cilia"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMucociliary Dysfunction: Balancing Homeostasis and Pathophysiology
Session in memory of Mary Rose.
Discussion Leaders: Burton Dickey (University of Texas MD Anderson Cancer Center, USA) and Silvia Kreda (CF Center, University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amSteven Brody (Washington University in St. Louis, USA)
"Mechanisms for Acquired and Genetic Motile Ciliopathies"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCecilia Lo (University of Pittsburgh, USA)
"Modeling the Complex Genetics of Ciliopathy in Mice"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJohanna Raidt (Universitaetsklinikum Muenster, Germany)
"Mucociliary Function in the Fallopian Tube"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amBruce Stanton (Geisel School of Medicine, Dartmouth College, USA)
"P. aeruginosa Inhibits CFTR Cl Secretion by Human Airway Epithelial Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMahmoud Abou Alaiwa (University of Iowa, USA)
"Determinants of Mucociliary Transport in CF Airways"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSuzanne Cloonan (Weill Cornell Medicine, USA)
"Regulation of Cilia Function by Selective Autophagy in Lung Disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Assembly and Glycosylation
Discussion Leaders: Martin Blum (University of Hohenheim, Germany) and Gunnar C. Hansson (University of Gothenburg, Sweden)
7:30 pm - 7:50 pmThomas Gerken (Case Western Reserve University, USA)
"Making Sense of Mucin O-Glycosylation: It's a Lot More Complicated than We Thought"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChris Kintner (Salk Institute for Biological Studies, USA)
"Transcriptional Regulation of Motile Ciliation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMary Porter (University of Minnesota, USA)
"Conserved Complexes Regulating Dynein Assembly and Ciliary Waveform"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMichael Tiemeyer (University of Georgia, USA)
"Functional Glycomics of Mucins"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMucociliary Defense and Immunity
Discussion Leaders: Ivana Yang (University of Colorado Denver, USA) and Alessandra Livraghi-Butrico (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amBruce Bochner (Feinberg School of Medicine, Northwestern University, USA)
"Mucin Sialylation Regulates Eosinophilic Airways Inflammation via Siglec Engagment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSumaira Hasnain (University of Queensland, Australia)
"Understanding Cytokine Regulation of Cellular Stress in Infectious and Inflammatory Disease at Mucosal Surfaces"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRodney Newberry (Washington University School of Medicine in St. Louis, USA)
"New Roles for Goblet Cells in Immunity"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amYogesh Saini (Louisiana State University, USA)
"Interactions Between Macrophages, Epithelial Cells, and Mucociliary Clearance Mechanisms"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGeorge Birchenough (University of Gothenburg, Sweden)
"Sentinel Goblet Cells: Goblet Cell-Mediated Mucosal Defense Beyond Mucus Layer Formation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLiping Zhang (National Institutes of Health, USA)
"Regulation of Mucin Biosynthesis and Secretion"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCellular and Developmental Aspects of Cilia and Mucus Biology
Discussion Leaders: Benedicte Durand (Claude Bernard University Lyon 1, France) and Michael McGuckin (Mater Research Institute - University of Queensland (MRI-UQ), Australia)
7:30 pm - 7:50 pmJeffrey Axelrod (Stanford University School of Medicine, USA)
"Uncoupling Centriole Replication from the Cell Cycle in Multiciliated Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmHiroshi Hamada (RIKEN Center for Developmental Biology, Japan)
"The Role of Immotile Cilia in Sensing the Fluid Flow for Left-Right Patterning"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRui Song (University of California, Berkeley, USA)
"miR-34/449 in Multiciliated Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmPascal Barbry (Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, France)
"Regulation of Motile Ciliogenesis by microRNAs"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Understanding of Muco- and Ciliopathies
Discussion Leaders: Mehmet Kesimer (University of North Carolina at Chapel Hill, USA) and Serge Amselem (INSERM, Pierre and Marie Curie University, UMRS 933, France)
9:00 am - 9:20 amBrian Button (University of North Carolina at Chapel Hill, USA)
"Biophysical Properties of MUC5B and MUC5AC Mucus in Health and Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPleasantine Mill (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"A Multi-System Approach to Define Regulatory Networks Necessary for Ciliary Motility"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDavid Schwartz (University of Colorado School of Medicine, USA)
"Idiopathic Pulmonary Fibrosis: A Genetic Disease that Involves Mucociliary Dysfunction of the Peripheral Airways"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMasahide Kikkawa (University of Tokyo, Japan)
"The Molecular Toolbox for Building Axonemal Microtubules"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMarie Legendre (INSERM, Pierre and Marie Curie University, UMRS 933, France)
"Genetic Heterogeneity in PCD: Efficiency and Limitations of NGS-Based Approaches"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMiriam Schmidts (Radboud University Nijmegen Medical Centre, The Netherlands)
"Large Scale Approaches to Understand Cilia and Ciliopathies"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Therapeutic Targets and Strategies for Disorders of Mucus and Cilia
Discussion Leaders: Chris Evans (University of Colorado Denver, USA) and Brigitte Gomperts (UCLA Children's Discovery and Innovation Institute, USA)
7:30 pm - 7:50 pmRichard Boucher (Marsico Lung Institute, University of North Carolina School of Medicine, USA)
"Therapeutic Strategies to Enhance Cilia, Mucus, and Mucociliary Functions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAmy Firth (University of Southern California, USA)
"iPS Cells for the Derivation of Motile Ciliated Cells and Applications for PCD and CF"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJung Soo Suk (Johns Hopkins University, USA)
"Mucus-Penetrating DNA Nanoparticles for Inhaled Gene Therapy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKim Nielsen (Copenhagen University Hospital, Denmark)
"Randomized Trials in PCD - Start of a New Era"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL135935-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter