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Directed Cell Migration
Gordon Research Conference

Mechanisms of Collective and Single Cell Motility in Development, Homeostasis and Disease

Dates

January 22-27, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Denise Montell

Vice Chair:
Orion D. Weiner

Meeting Description

Directed cell migration is a spectacular feature of normal development and tissue homeostasis. Without cell migration, embryos would not develop, wounds would never heal, and the immune system could neither form nor function. However cancer cells hijack these beneficial cell motility mechanisms to spread through the body. The objective of the 2017 Directed Cell Migration Gordon Conference is to bring together an international group of young and senior scientists who share a common interest in cell migration to exchange their cutting edge approaches and breakthrough discoveries. This conference will provide an opportunity to develop interactions and collaborations among scientists from multiple disciplines that are related to directed cell migration, including participants from the fields of immunology and inflammation, cancer invasion and metastasis, embryological development and tissue repair, as well as related fields, including engineering, physics and computational biology. This high level of scientific interaction will encourage the attendees to learn about latest research findings, develop novel hypotheses, and enhance insight into how cell migration contributes to disease. The session speakers, selected from a variety of fields, will emphasize novel, unpublished results directly related to gradient sensing and directed cell migration. Young investigators will be encouraged to present and discuss their findings in a supportive environment through the invitation of up to 20 additional speakers, selected from submitted abstracts, by participation in the posters sessions and through the associated Gordon Research Seminar. Throughout the conference and seminar, interactions between senior and young investigators will be promoted in both formal and informal settings.

Related Meeting

This GRC was held in conjunction with the "Directed Cell Migration" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: 25 Years of Rac and Rho
Session in honor of Alan Hall.
Discussion Leader: Tatiana Omelchenko (Memorial Sloan Kettering Cancer Center, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmAnne Ridley (King's College London, United Kingdom)
"Migration Across the Endothelial Barrier"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmSandrine Etienne-Mannevile (Institut Pasteur, France)
"Role of Intermediate Filaments in Directed Collective Migration"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDirected Cell Migration in Development
Discussion Leader: Andrew Ewald (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:25 amRoberto Mayor (University College London, United Kingdom)
"Collective Cell Migration During Development: The Case of the Neural Crest"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amSally Horne-Badovinac (University of Chicago, USA)
"Fat2 and Lar Promote Epithelial Migration by Coordinating Leading Edge Trailing Edge Dynamics Between Neighboring Cells"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amTatiana Omelchenko (Memorial Sloan Kettering Cancer Center, USA)
"The Small Rho GTPase GEF Beta-Pix Regulates Collective Mesoderm Migration In Vivo"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amDaria Siekhaus (Institute of Science and Technology Austria, Austria)
"Drosophila TNF, Eiger, Regulates Tissue Tension Through the Crumbs Complex to Facilitate Macrophage Invasive Migration During Embryogenesis"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amBrian Stramer (King's College London, United Kingdom)
"Contact Inhibition Drives the Even Distribution of ECM During Drosophila Development"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmEduardo Moreno (Champalimaud Foundation, Portugal)
"Oncogene Induced Cell Intercalation and Tissue Destruction"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemotaxis Signaling
Discussion Leader: Milka Sarris (University of Cambridge, United Kingdom)
7:30 pm - 7:55 pmCarole Parent (National Cancer Institute, NIH, USA)
"Exosomes as Key Regulators of Signal Relay During Chemotaxis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRobert Insall (University of Glasgow, United Kingdom)
"Self-Generated Gradients - Chemotaxis Works Differently when Cells Make Their Own Directions"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPeter Devreotes (Johns Hopkins University School of Medicine, USA)
"Excitable Networks in Directed Cell Migration"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPeter Van Haastert (University of Groningen, The Netherlands)
"New Signaling Networks for Symmetry Breaking and Directed Cell Movement"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDirected Cell Migration in Wound Repair
Discussion Leader: Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:25 amAnna Huttenlocher (University of Wisconsin-Madison, USA)
"Chemokine Signaling in Bidirectional Migration"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amWilliam Holmes (Vanderbilt University, USA)
"Crosstalk Between Rac and Rho GTPases Promote Morphological Heterogeneity Among Motile Cells"
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amTobias Meyer (Stanford University, USA)
"Engulfed Cadherin Fingers Guide Endothelial Cells During Collective Migration"
10:15 am - 10:25 amDiscussion
10:25 am - 10:35 amAbhijit Deb Roy (University of Connecticut Health Center, USA)
"An Optogenetic Approach to Elucidate Contact Inhibition of Locomotion Between Osteoclasts and Osteoblasts"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amWill Wood (University of Bristol, United Kingdom)
"Detecting Death and Damage: Macrophage Migration in Drosophila"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amVaruzhan Balasanyan (University of California, Santa Barbara, USA)
"Cells Recovering from the Brink of Apoptotic Cell Death Acquire Migration Capacity Through TGFβ Signaling and Snail"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSylvain Gabriele (University of Mons, Belgium)
"The Mechanosensitivity of Motile Keratocytes Depends on α5β1 Integrin Engagement"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Migration in Cancer
Discussion Leader: Celeste Nelson (Princeton University, USA)
7:30 pm - 7:55 pmAndrew Ewald (Johns Hopkins University School of Medicine, USA)
"Collective Cell Migrations Driving Mammary Morphogenesis and Breast Cancer Metastasis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmErik Sahai (The Francis Crick Institute, United Kingdom)
"Cancer Cell Invasion in Complex Environments"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmMeghan Driscoll (University of Texas Southwestern Medical Center, USA)
"Identifying Stereotypical Cellular Morphological Structures from High-Resolution 3D Images of Living Cells"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmCynthia Reinhart-King (Vanderbilt University, USA)
"Mechanical and Structural Matrix Cues Direct Metastatic Cell Migration"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmune Cell Migration
Discussion Leader: Anna Huttenlocher (University of Wisconsin-Madison, USA)
9:00 am - 9:25 amRonald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Imaging the Immune System – Insights into Control of Cell Directionality and Migration"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amMilka Sarris (University of Cambridge, United Kingdom)
"Gradient Sensing in Interstitial Leukocyte Migration"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amJudy Cannon (University of New Mexico School of Medicine, USA)
"Environmental Influences on T Cell Motion in Intact Tissues"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amDaniel Irimia (Harvard Medical School, USA)
"Multiple Chemoattractants and One Stop Signal Mediate Human Neutrophil Swarming"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amOrion Weiner (UCSF School of Medicine, USA)
"Signal Integration During Neutrophil Chemotaxis"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amTian Jin (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Phagocytes of Dictyostelium and Neutrophils Use Chemoattractant GPCRs to Mediate both Chemotaxis and Phagocytosis for Catching and Ingesting Bacteria"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTakanari Inoue (Johns Hopkins University, USA)
"Membrane Curvature Dictates Local PI3K Signaling"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMechanics of Cell Migration
Discussion Leader: Tobias Meyer (Stanford University, USA)
7:30 pm - 7:55 pmNir Gov (Weizmann Institute of Science, Israel)
"Theoretical Models for Single and Collective Cell Motility"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmClare Waterman (National Institutes of Health, USA)
"FMN2 Is a Melanoma Metastasis-Promoter that Mediates Formation of a Perinuclear Actin/Adhesion System to Protect Nuclei and DNA from Damage During Confined Cell Migration"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmRobert Kay (MRC Laboratory of Molecular Biology, United Kingdom)
"The Piezo Channel Transduces Mechanical Information to Control How Dictyostelium Cells Move"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmChristalyn Rhodes (Harvard T.H. Chan School of Public Health, USA)
"Rhinovirus Induces TGF-Beta Dependent Collective Cellular Migration in Airway Epithelial Cells in Normal and Asthmatic Donors"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMigration and Metastasis
Discussion Leader: Erik Sahai (The Francis Crick Institute, United Kingdom)
9:00 am - 9:25 amPeter Friedl (Radboud University Medical Center, The Netherlands)
"Plasticity of Cell Migration: Integrins and the Microenvironment"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amRaghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"The Biology and Function of EMT in Pancreatic Cancer"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amMinna Roh (Fred Hutchinson Cancer Research Center, USA)
"Macrophage-Dependent Cytoplasmic Transfer Drives Melanoma Metastasis In Vivo"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amAdam Marcus (Emory University School of Medicine, USA)
"Image-Guided Genomics Reveals Cellular Symbiosis During Cancer Invasion"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amFanny Jaulin (Institut Gustave Roussy, France)
"Collective Epithelial-Based Metastases in Colorectal Carcinoma Patients"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJennifer Mitchel (Harvard T.H. Chan School of Public Health, USA)
"The Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJamie Nosbisch (North Carolina State University, USA)
"A Reaction-Diffusion Model Explains Amplification of the Phospholipase C/Protein Kinase C Pathway in Fibroblast Chemotaxis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCytoskeleton Dynamics in Migrating Cells
Discussion Leader: Sandrine Etienne-Mannevile (Institut Pasteur, France)
7:30 pm - 7:55 pmJames Bear (University of North Carolina School of Medicine, USA)
"GPCR vs. RTK Chemotaxis in Fibroblasts: Putting Old Players to Work in New Ways"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmJordan Beach (National Heart, Lung, and Blood Institute, NIH, USA)
"Actin Dynamics and Competition for Myosin Monomer Govern the Sequential Amplification of Myosin Filaments"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMargaret Gardel (The University of Chicago, USA)
"Spatial Regulation of RhoA Reveals Zyxin-Mediated Elasticity of Stress Fibers"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMichael Sixt (Institute of Science and Technology Austria, Austria)
"Topography-Based Force Transduction"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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