Applications for this meeting must be submitted by July 9, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
The Gordon Research Conference (GRC)
and the associated Gordon Research Seminar (GRS) on Hormone Dependent Cancer
will bring together basic biologists, cancer
modellers and clinicians who are focused on understanding hormone dependent
cancer and ways of improving the treatment of these diseases.
The major themes will include understanding cancer pathways and processes, how these
are corrupted or altered during cancer progression and how novel therapies work
mechanistically and what impact cancer perturbations (i.e. mutations) have on
the activity of these therapies. In parallel, a major focus
will be the development, validation and application of better, more
physiologically relevant models for studying hormone dependent cancer and
investigation into the role of the tumor microenvironment. A recent advance in
the field has been the understanding and exploitation of pathway cross-talk in
hormone dependent cancer, which will also compose a part of the conference. Several distinct levels of biology will be represented in this meeting,
including the hormones/ligands, the receptors, the downstream transcription
factors that mediate the gene expression events and the role of DNA and genetic
mutations in this process. Whilst a small part of the meeting will focus on
these variables in normal healthy tissue, the
bulk of the meeting will address these variables in the context of cancer and
the events that go awry during disease development and progression.
This GRC will be held in conjunction with the "Hormone-Dependent Cancers" Gordon Research Seminar (GRS)
. Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page
for more information.
The topics and speakers for the conference sessions are displayed below (italics denote discussion leaders). The Conference Chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by April 6, 2017. Please check back for updates.
Keynote Session: Genomic Approaches to Understanding Hormone Dependent Cancer
(Geoffrey Greene, Mathieu Lupien / Elaine Mardis / Rene Bernards)
Receptor Function and Co-Factors
(Robert Clarke, Qianben Wang / Zeynep Madak Erdogan / Inez Rogatsky / Donald McDonnell)
Mutational Changes in Hormone Dependent Cancer
(Sarat Chandarlapaty, Scott Dehm / Adrian Lee / Doug Levine / Nicholas Turner)
Functional Genomics, Non-Coding RNA and Epigenomics
(Simak Ali, Felix Feng / Matthew Freedman / Rachael Natrajan / Wilbert Zwart / Lee Kraus)
(Suzanne Conzen, Senthil Muthuswamy / Christopher Ormandy / Pepper Schedin)
(Ganesh Raj, Wayne Tilley / Karen Knudsen / Daniel Frigo / Daniel Gioeli / Carol Sartorius)
(Alex Swarbrick, Scott Tomlins / Christina Curtis / Jorge Reis-Filho / Massimo Loda / Scott Cramer)
Modelling Cancer and Novel Therapeutics
(Elgene Lim, Saraswati Sukumar / Lori Friedman / Rachel Schiff / Cathrin Brisken / Alana Welm)
Keynote Session: Chemistry to Biology and Novel Approaches for Understanding Cancer Biology
(Chris Sweeney, Luca Magnani / Timothy Willson / Gordon Hager)