Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Organelle Trafficking
Discussion Leader: Anna Katharina Simon (The Kennedy Institute of Rheumatology, University of Oxford, United Kingdom)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
"Regulation of Autophagy by the Trafficking Machinery"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Fulvio Reggiori (University of Groningen, The Netherlands)
"Insights into the Mechanism of Autophagosome Biogenesis from Yeast"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
David Rubinsztein (University of Cambridge, United Kingdom)
"Coincident Detection of PI3P-RAB11A by WIPI2 Enables Autophagosome Formation on RAB11A-Positive Compartment"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosomes: The Final Destination
Discussion Leader: Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
9:00 am - 9:20 am
J. Paul Luzio (Cambridge Institute for Medical Research, University of Cambridge, United Kingdom)
"Lysosomes and Endolysosomes: The Dynamics of the Late Endocytic Pathway"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"The Lysosome Cargo Response"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Andreas Jenny (Albert Einstein College of Medicine, USA)
"Regulation of Endosomal Microautophagy in Drosophila "
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Jose Nieto Torres (Sanford Burnham Prebys Medical Discovery Institute, USA)
"LC3 Phosphorylation Is Critical for Directional Transport of Autophagic Vesicles"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Marja Jaattela (Danish Cancer Society Research Center, Denmark)
"Signalling Networks Controlling AMPK Activation and Autophagy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Stephanie Erjavec (Columbia University, USA)
"Role of the Autophagic Protein, STX17, in Melanogenesis and Alopecia Areata"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Andrea Ballabio (Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"Cross-Talk Between mTORC1 and TFEB Regulates the Adaptive Response to Nutrient Availability and Promotes Cancer Growth"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Anna Katharina Simon (The Kennedy Institute of Rheumatology, University of Oxford, United Kingdom) and Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Basic Biology of Autophagy
Discussion Leader: Li Yu (Tsinghua University, China)
6:00 pm - 6:20 pm
Noboru Mizushima (The University of Tokyo, Japan)
"Novel Roles of Autophagy in Vertebrate Development"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Eleazar Rodriguez (University of Copenhagen, Denmark)
"Autophagy Contributes to Somatic Cell State Reprogramming in Plants"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Tamotsu Yoshimori (Osaka University, Japan)
"New Insights into Autophagic Regulation and Anti-Disease Function"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
James Hurley (University of California, Berkeley, USA)
"How Rubicon Allosterically Inhibits Membrane Docking by the Autophagic PI 3-Kinase Complex"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
Selected from Poster Abstracts: Michael Shtutman (University of South Carolina, USA)
"COPI Complex Depletion: ROS, Lipid Droplets and Autophagy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Basic Mechanisms of Autophagosome Formation
Discussion Leader: Anne Simonsen (University of Oslo, Norway)
9:00 am - 9:20 am
Sharon Tooze (The Francis Crick Institute, United Kingdom)
"Regulation of Autophagosome Formation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Claudine Kraft (University of Freiburg, Germany)
"Molecular Regulation of Autophagy: Atg1/ULK1 and Friends"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Lisa Frankel (BRIC, University of Copenhagen, Denmark)
"Eukaryotic Translation Initiation Factor 5A Mediates Translational Control of Autophagy via ATG3"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
Hong Zhang (Chinese Academy of Sciences, China)
"The Molecular Mechanism Underlying Establishment and Maintenance of the ER/Isolation Membrane Contact"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
Zvulun Elazar (Weizmann Institute of Science, Israel)
"Role of Lipid Synthesis in Autophagosome Biogenesis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Martin Graef (Max Planck Institute for Biology of Aging, Germany)
"Acyl-CoA Synthetases Activate Fatty Acids on Forming Autophagosomes to Drive Autophagy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Tobias Eisenberg (University of Graz, Austria)
"Lipid Metabolism in the Regulation of Autophagy and Ageing in Yeast"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Rachel Ulferts (University of Cambridge, United Kingdom)
"Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but Has a Distinct Molecular Basis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Selective Autophagy
Discussion Leader: Sharon Tooze (The Francis Crick Institute, United Kingdom)
6:00 pm - 6:20 pm
Alexander M. Cruickshank Lecture: Ivan Dikic (Goethe University Frankfurt, Germany)
"Selective Autophagy and ER Remodelling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Seungmin Hwang (The University of Chicago, USA)
"Targeting the Membranous Shelters of Pathogens via Autophagy Proteins"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Anne Simonsen (University of Oslo, Norway)
"Regulation of Selective Autophagy by Lipid-Binding Proteins"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Selected from Poster Abstracts: Mija Marinkovic (School of Medicine, University of Split, Croatia)
"Regulation of Nix-Mediated Mitophagy by Dimerization and Phosphorylation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Felix Randow (MRC Laboratory of Molecular Biology, United Kingdom)
"How Cells Deploy Autophagy to Defend Against Invading Bacteria"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Immunity
Discussion Leader: Felix Randow (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:20 am
Herbert Virgin (Washington University School of Medicine, USA)
"Role of ATG Genes in Regulating Inflammation and Immunity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Oliver Florey (Babraham Institute, United Kingdom)
"The WD40 Domain of ATG16L1 Supports Non-Canonical Autophagy and Dendritic Cell Antigen Presentation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Ioannis Nezis (University of Warwick, United Kingdom)
"Kenny Mediates Selective Autophagic Degradation of the IKK Complex to Control Innate Immune Responses"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Hanlin Zhang (University of Oxford, United Kingdom)
"Translational Control of Autophagy Rejuvenates Immune Responses via eIF5A and TFEB"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Vojo Deretic (University of New Mexico Health Sciences Center, USA)
"How Innate Immune Functions of Autophagy Teach Us About Its Fundamental Mechanisms"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Ramnik Xavier (Massachusetts General Hospital, USA)
"Autophagy, Microbial Sensors and Mucosal Immunity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: John Steven Ekman (Washington University in St. Louis School of Medicine, USA)
"Atg14 Protects the Intestinal Epithelium from TNF-Induced Apoptosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Jayanta Debnath (University of California, San Francisco, USA)
"Defining an LC3-Dependent Functional Circuit that Specifies Exosome Loading and Secretion"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Drug Discovery
Discussion Leader: Leon Murphy (Third Rock Ventures, USA)
6:00 pm - 6:20 pm
Christina Eng (Pfizer, USA)
"Intrinsic and Extrinsic Roles of Autophagy in Tumors"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Francesca Moretti (Novartis Institutes for BioMedical Research, Switzerland)
"Phenotypic Screening Paradigms for Autophagy Pathway Regulators"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Selected from Poster Abstracts: Benjamin Dehay (Institute of Neurodegenerative Diseases, University of Bordeaux, France)
"Development of New PLGA Nanoemulsion Formulation to Restore Lysosomal Dysfunction in Parkinson's Disease"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Ana Maria Cuervo (Albert Einstein College of Medicine, USA)
"Malfunctioning of Chaperone-Mediated Autophagy in Aging and Age-Related Diseases"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
General Discussion: Target Autophagy to Improve Healthspan
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Age-Related Diseases
Discussion Leaders: Anna Katharina Simon (The Kennedy Institute of Rheumatology, University of Oxford, United Kingdom) and Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:20 am
Ralph Nixon (NYU Langone Medical Center, USA)
"Lysosomal pH Regulation: Emerging Roles in Neurodegenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Selected from Poster Abstracts: Patricia Boya (Centro de Investigaciones Biológicas, CSIC, Spain)
"Mitophagy as a Regulator of Metabolism and Cell Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Davor Ivankovic (University College London, United Kingdom)
"Defective Axonal Autophagosome Maturation in AP-4 Deficiency Syndrome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Veronik Lachance (Icahn School of Medicine at Mount Sinai, USA)
"Understanding the Potential Role for Dysregulation of Autophagy Complexes, ULK1 and PI3KC3, in Predisposing Pathogenesis of Alzheimer's Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Tor Rusten (The Norwegian Radium Hospital, Norway)
"Autophagy and Cancer-Lessons from Drosophila "
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Kevin Ryan (Cancer Research UK Beatson Institute,, United Kingdom)
"Autophagy in Cell Death and Cancer"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Werner Kovacs (ETH Zurich, Switzerland)
"Exploring the Molecular Mechanism of Hif-2a-Mediated Pexophagy and the Role of Pexophagy in Tumorigenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Carmine Settembre (University of Naples / Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"Modulation of Collagen Trafficking by Autophagy as a Therapy for Bone Disorders"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Congcong He (Northwestern University, USA)
"Differential Roles of Chronic Autophagy in Insulin Production and Sensitivity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Autophagy in Aging
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
6:00 pm - 6:20 pm
Nektarios Tavernarakis (Foundation for Research and Technology - Hellas, Greece)
"Mitochondrial Turnover and Neuronal Homeostasis During Ageing"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Selected from Poster Abstracts: Alberto Negrete Hurtado (CECAD, University of Cologne, Germany)
"Non-Canonical Role of Autophagy in Neurotrophin Signaling and Axonal Homeostasis"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Selected from Poster Abstracts: Caroline Kumsta (Sanford Burnham Prebys Medical Discovery Institute, USA)
"The Autophagy Receptor SQSTM1/p62 Promotes Longevity in C. elegans "
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Noopur Khobrekar (Columbia University Medical Center, USA)
"RFLP is an mTOR Regulated Dynein Motor Adaptor Protein Required for Mammalian Autophagosome Assembly and Transport"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure