SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | THE IMMUNOBIOLOGY OF CROSS PRESENTATION |
| Discussion Leader: Peter Cresswell (Yale University, USA) |
7:40 pm - 8:20 pm | Keynote Address: Michael Bevan (University of Washington & HHMI, USA)
"Antigen Presentation to CD8 T cells" |
8:20 pm - 8:30 pm | Discussion |
8:20 pm - 8:45 pm | Hidde Ploegh (Massachusetts Institute of Technology, USA)
"Cloned mice, protein surgery and other tools to explore cross-presentation" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Nilabh Shastri (University of California at Berkeley)
"Direct and indirect presentation of ligands for immunesurveillance" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CROSS PRESENTATION IN HEALTH AND DISEASE |
| Discussion Leader: Vincenzo Barnaba (University of Rome, Italy) |
9:00 am - 9:25 am | Vincenzo Barnaba (University of Rome, Italy)
"Chronic immune activation, cross-presentation, and apoptosis: a liaison à trois in chronic infections" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Anne Hossmalin (Cochin Institute, France)
"Dendritic cell cross-priming from live cells in vivo" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:55 am | Bruce Robinson (NCARD, Australia)
"Tumor antigen cross-presentation -- the crossroads of successful anticancer therapy" |
10:55 am - 11:05 am | Discussion |
11:10 am - 11:35 am | Marina Botto (Imperial College London, UK)
"Complement, apoptosis and cross-presentation - a link to systemic autoimmunity?" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | David Lewinsohn (OHSU, Portland, USA)
"The Mycobacterium Tuberculosis Phagosome is a HLA-I Processing Competent Organelle" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | INNATE IMMUNITY AND CROSS PRESENTATION - I |
| Discussion Leader: Greg Lemke (Salk Institute, USA) |
5:30 pm - 5:55 pm | Greg Lemke (Salk Institute, USA)
"TAM receptor regulation of the innate immune response" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 6:30 pm | Edith Janssen (Cincinnati Children's Hospital, USA)
"Potent CD4 and CD8 T cell priming to cell-associated antigens by merocytic DC" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:05 pm | Greg Barton (University of California at Berkeley)
"Common principles controlling TLR function and antigen cross presentation" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Erika Reynoso (Harvard University, USA)
"Presentation of intestinal self-antigen leads to autoimmune enteritis upon PD-L1 blockade" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | INNATE IMMUNITY AND CROSS PRESENTATION - II |
| Discussion Leader: Pamela Ohashi (Ontario Cancer Institute, Canada) |
9:00 am - 9:25 am | Michel Gilliet (M.D. Anderson Cancer Center, USA)
"Antimicrobial peptides break innate tolerance to self-nucleic acids in autoimmunity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | William Heath (WEHI, Australia)
"Antigen presentation and T cell immunity to skin infection with HSV-1" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Ferry Ossendorp (Leiden University Medical Center)
"Antigen storage compartments in DC" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Pierre Guermonprez (Curie Institute, France)
"A role for lipid bodies in antigen cross presentation" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Dietmar Zaiss (University of Utrecht, The Netherlands)
"How the antigen processing pathway prevents CD8 T cell responses to self antigens" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Manoury Benedicte (Curie Institute, France)
"Critical role for Asparagine Endopeptidase in endocytic TLR signalling in dendritic cells" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Evelina Gatti (CNRS, France) "Ubiquitination and MARCH I prevent MHC class II plasma membrane stabilization in non-activated dendritic cells" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | CELL DEATH AND CROSS PRESENTATION |
| Discussion Leader: Douglas Green (St. Jude Children's Research Hospital, USA) |
5:30 pm - 5:50 pm | Douglas Green (St. Jude Children's Research Hospital, USA)
"How apoptotic cells induce tolerance" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Guido Kroemer (INSERM, France)
"The immune response against dying tumor cells: a key-lock paradigm" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Matthew Albert (Pasteur Institute, France)
"The role of autophagy in antigen cross-presentation" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Serge Grinstein (University of Toronto, Canada)
"Determinants of phagosome formation and maturation" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | THE CELL BIOLOGY OF CROSS PRESENTATION - I |
| Discussion Leader: Ira Mellman (Genentech, USA) |
9:00 am - 9:25 am | Laurence Zitvogel (Gustave Roussy Institute, France)
"Contribution of dendritic cells to the efficacy of chemotherapy against cancer: a powerful 'allié'" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Christian Munz (University of Zurich, Switzerland)
"Macroautophagy in innate and adaptive immunity" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Ira Mellman (Genentech, USA)
"Endosome function in antigen presentation" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Peter van Endert (Hopital Neckar, France)
"A trimming peptidase identifies an endosomal MHC class I cross-presentation compartment" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | David Russell (Cornell University, USA)
"Modulation of phagosome function revealed by real-time readouts" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:30 pm | CELL BIOLOGY OF CROSS PRESENTATION - II |
| Discussion Leader: Michel Desjardins (University of Montreal, Canada) |
5:30 pm - 5:55 pm | Michel Desjardins (University of Montreal, Canada)
"Nuclear membrane-derived autophagy participates in the presentation of viral proteins on MHC class I" |
5:55 pm - 6:05 pm | Discussion |
6:05 pm - 7:10 pm | Jacques Neefjes (Netherlands Cancer Institute, NL)
"Cholesterol and other processes in MHC class I cross-presentation" |
7:10 pm - 7:20 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADAPTIVE IMMUNITY AND CROSS PRESENTATION - I |
| Discussion Leader: William Heath (Monash University, Australia) |
9:00 am - 9:25 am | Jose Villandangos (WEHI, Australia)
"Mechanisms of Antigen Cross-presentation in CD8+ Dendritic Cells" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Christian Kurts (IMMEI, Germany)
"Distinct roles of cross-presenting and non-cross-presenting DCs in T cell-mediated glomeruloenephritis" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Kenneth Murphy (Washington University & HHMI, USA)
"Regulation of dendritic cell heterogeneity by AP-1 family transcription factors" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Romina Goldszmid (National Institutes of Health, USA)
"A functional role for host ER-parasitophorous vacuole interaction in cross-presentation of Toxoplasma gondii-derived antigens" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Phillipe Pierre (CNRS, France)
"Defective ribosomal proteins are substrates for endogenous antigens MHC II-restricted presentation in immature DCs and DALIS formation upon activation" |
11:50 pm - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Javier Hernandez (Institut de Genetique Moleculaire de Montpelier, France)
"Memory-like CD8+ T Cells require antigen-specific CD4 help to overcome cross-tolerance under lymphopenic conditions" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Malini Raghavan (University of Michigan, USA)
"Calreticulin's role in antigen presentation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time |
5:30 pm - 7:30 pm | ADAPTIVE IMMUNITY AND CROSS PRESENTATION - II |
| Discussion Leader: Pramod Srivastava (University of Connecticut, USA) |
5:30 pm - 6:00 pm | Pramod Srivastava (University of Connecticut, USA)
"Nature of the antigen transferred from the antigen donor cell to the antigen presenting cell" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:40 pm | Thomas Brocker (Ludwig-Maximillian University, Germany)
"Cross presentation during viral infection and vaccination" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:20 pm | Kenneth Rock (University of Massachusetts, USA)
"Mechanisms of MHC class I presentation" |
7:20 pm - 7:30 pm | Discussion / Concluding Remarks |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |