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Aging, Biology of
Gordon Research Conference

The Translational Science of Aging: From Functional Pathways to Interventions

Dates

July 19-24, 2015

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chairs:
John M. Sedivy & Yousin Suh

Vice Chairs:
Adam Antebi & Shin-Ichiro Imai

Meeting Description

The 2015 Gordon Research Conference on Biology of Aging will highlight fundamental processes and pathways of aging emerging from studies of model organisms, how these concepts advance our understanding of human aging and age associated diseases, and how this knowledge can be translated into successful interventions to ameliorate the functional decline of age. The topics will include: the genetics and epigenetics of aging, genome stability, stem cells and rejuvenation, cellular senescence, protein homeostasis and autophagy, neuroendocrine regulation, and metabolic regulation and mitochondria. The meeting will close with a session on developing therapeutic strategies for aging and age-associated diseases. The meeting will be conducted in an atmosphere that facilitates reciprocal exchange between scientists working in experimental models and those involved in studies of human biology, and will promote interactions among established investigators and newcomers to the field. The preceding Gordon Research Seminar will encompass the same range of topics and will focus on advancing the careers of the next generation of scientists in the aging field.

Related Meeting

This GRC was held in conjunction with the "Aging, Biology of" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Translational Science of Aging
Discussion Leaders: John Sedivy (Brown University, USA) and Yousin Suh (Albert Einstein College of Medicine, USA)
7:40 pm - 8:15 pmCynthia Kenyon (Calico, USA)
"Pathways that Enhance Proteostasis in C. elegans"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmLuigi Ferucci (National Institute on Aging, NIH, USA)
"Inflammation Is a Hallmark of Aging"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmFelipe Sierra (National Insitute on Aging, NIH, USA)
"Geroscience and Translation: Are We There Yet?"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmNir Barzilai (Albert Einstein College of Medicine, USA)
"The Promise of Taming Aging in Humans"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetics and Genome Stability
Discussion Leader: Jan Vijg (Albert Einstein College of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amPeter Adams (University of Glasgow, United Kingdom)
"The Dynamic Epigenome – A Challenge to Healthy Aging"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amVera Gorbunova (University of Rochester, USA)
"Longevity Mechanisms in the Naked Mole Rat"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 10:55 amSylvia Lee (Cornell University, USA)
"Chromatin Regulation Is Key to Longevity in C. elegans"
10:55 am - 11:00 amDiscussion
11:00 am - 11:15 amStephen Helfand (Brown University, USA)
"Retrotransposons as Agents of Somatic Diversity, Disease and Aging"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Andrei Seluanov (University of Rochester, USA)
"Reverse Transcriptase Inhibitors Rescue Features of Premature Aging in SIRT6 Knockout Mice"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Evandro Fang (National Institute on Aging, NIH, USA)
"Defective Mitochondrial Autophagy in Premature Aging Disorders"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Silvia Gravina (Albert Einstein Collge of Medicine, USA)
"Aging Single-Cell Methylomes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Graeme Hewitt (Newcastle University, United Kingdom)
"p62 – Linking Protein Homeostasis and the DNA Damage Response During Aging"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetics of Aging
Discussion Leader: Claudio Franceschi (University of Bologna, Italy)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmMatt Kaeberlein (University of Washington, USA)
"Mitochondrial Disease and Normative Aging: Common Pathways and Conserved Mechanisms?"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmJanet Lord (Birmingham University Medical School, United Kingdom)
"Immunesenescence: Intrinsic Aging Versus Lifestyle Effects"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJoris Deelen (Leiden University Medical Center, The Netherlands)
"Whole-Genome Sequencing in the Oldest Old"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Wallace Chick (University of Colorado Denver, USA)
"Uncovering New Longevity Targets in Mice"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTelomeres and Cellular Senescence
Discussion Leader: Sandy Chang (Yale University of School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amMary Armanios (John Hopkins School of Medicine, USA)
"The Telomere Syndromes: A Paradigm for Molecular Medicine"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amDarren Baker (Mayo Clinic, USA)
"Clearing Naturally Occurring Senescent Cells Improves Health and Extends Lifespan"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amM. Geoffrey Rosenfeld (University of California, San Diego, USA)
"Enhancer Mechanisms and Cellular Senescence"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Tamir Chandra (Wellcome Trust Sanger Institute / Babraham Institute, United Kingdom)
"Global Reorganization of the Nuclear Landscape in Senescent Cells"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Nicola Neretti (Brown University, USA)
"Reorganization of Chromosome Architecture in Replicative Cellular Senescence"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Johannes Grillari (University of Natural Resources and Life Sciences (BOKU), Vienna Institute of BioTechnology, Austria)
"From Replicative Senescence to Diagnostics of Age-Associated Diseases: A Story of Translation"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Maria Almeida (University of Arkansas for Medical Sciences, USA)
"Restraining Mitochondrial H2O2 Generation in Cells of the Osteoblast, but Not Osteoclast Lineage, Abrogates the Adverse Effects of Aging on the Murine Skeleton"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cells and Rejuvenation
Discussion Leader: Amy Wagers (Harvard University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmThomas Rando (Stanford University, USA)
"Epigenetic Regulation of Stem Cell Aging"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmHenri Jasper (Buck Institute, USA)
"Stem Cells and Aging: Lessons from Drosophila"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Joseph Castellano (Stanford University School of Medicine, USA)
"Proteins in Human Umbilical Cord Plasma Improve Neuronal and Cognitive Function in Aged Mice"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Blanka Rogina (University of Connecticut Health Center, USA)
"Indy Reduction Maintains Fly Health and Homeostasis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMetabolic Regulation and Mitochondria
Discussion Leader: Shin-Ichiro Imai (Washington University School of Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMarcia Haigis (Harvard Medical School, USA)
"Revisiting Mitochondria in Aging"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amPeter Rabinovitch (University of Washington, USA)
"Extending Cardiac Healthspan by Enhancing Mitochondrial Function in Mice"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amSelected from Poster Abstracts: Seung-Jae Lee (Pohang University of Science and Technology, South Korea)
"Promotion of Fat Synthesis by SREBP and MDT-15 Ameliorates Toxic Effects of Glucose on C. elegans Lifespan"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amCoffee Break
10:55 am - 11:10 amRozalyn Anderson (University of Wisconsin-Madison, USA)
"Calorie Restriction in Monkeys: The NIA and WI Studies (Part I)"
11:10 am - 11:15 amDiscussion
11:15 am - 11:30 amJulie Mattison (National Institute on Aging, NIH, USA)
"Calorie Restriction in Monkeys: The NIA and WI Studies (Part II)"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amLuigi Fontana (Brescia University, Italy / Washington University, USA)
"Promoting Health and Longevity Through Diet"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmRafa De Cabo (National Institute on Aging, NIH, USA)
"Longevity Effects of CR: Where Are We Now?"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNeuronal Aging in Model Systems
Discussion Leader: Marc Tatar (Brown University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmColeen Murphy (Princeton University, USA)
"Insulin Signaling and Cognitive Aging"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmAkiko Satoh (Washington University in St. Louis School of Medicine, USA)
"Aging and Sleep: The Role of Sirt1/Nkx2-1-Double Positive Neurons in the Dorsomedial Hypothalamus"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmSelected from Poster Abstracts: Ao-Lin Hsu (University of Michigan, USA)
"The Regulation and Restoration of Age-Associated Functional Decline at Neuromuscular Junctions"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmSelected from Poster Abstracts: Ashley Webb (Brown University, USA)
"Meta-Analysis of Genome-Wide Targets of the Pro-Longevity FOXO Transcription Factors"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Irene Alfaras Cardenal (National Institute on Aging, NIH, USA)
"On-and-Off Treatment with a High Dose of Metformin Improves Insulin and Leptin Sensitivity"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Homeostasis and Therapeutic Applications
Discussion Leader: Anne Brunet (Stanford University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amDaniel Gottschling (Fred Hutchinson Cancer Research Center, USA)
"Organelle Deterioration with Age: The Limits of an Interconnected Cellular System"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amMalene Hansen (Sanford-Burnham Medical Research Institute, USA)
"Understanding the Role of TOR-Regulated Processes in Aging and Disease"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amCoffee Break
10:30 am - 10:55 amJoan Mannick (Novartis Institutes for Biomedical Research, USA)
"mTOR Inhibition Improves Immune Function in Elderly Humans"
10:55 am - 11:05 amDiscussion
11:05 am - 11:20 amSelected from Poster Abstracts: Rolf Bodmer (Sanford-Burnham Medical Research Institute, USA)
"Cardiac Functional Aging in Drosophila: A Matter of Balance"
11:20 am - 11:25 amDiscussion
11:25 am - 11:40 amSelected from Poster Abstracts: Albert Shaw (Yale School of Medicine, USA)
"Age-Associated Alterations in Gene Expression and a Mitochondrial Signature of Influenza Vaccine Response"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Samantha Biet (University of Sydney, Australia)
"Aging and Late Life Health: Calories or Macronutrients?"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Marissa Fletcher (Massachusetts Institute of Technology, USA)
"The DAF-7/TGF-β Pathway Is Required for Lifespan Extension Mediated by Dietary Restriction in C. elegans"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Michael Stout (Mayo Clinic, USA)
"17a-Estradiol Curtails Age-Related Metabolic Dysfunction"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmDeveloping Therapeutic Strategies for Aging and Age-Associated Diseases
Discussion Leader: Nir Barzilai (Albert Einstein College of Medicine, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 5:50 pmBrian Kennedy (The Buck Institute, USA)
"Preclinical Models to Evaluate Age-Delaying Drugs"
5:50 pm - 5:55 pmDiscussion
5:55 pm - 6:05 pmJames Kirkland (Mayo Clinic, USA)
"Scenarios for Initial Clinical Trials of Drugs that Target Fundamental Aging Mechanisms"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:20 pmValter Longo (University of Southern California, USA)
"Interventions to Extend Human Healthspan"
6:20 pm - 6:25 pmDiscussion
6:25 pm - 6:35 pmPark SangChul (Samsung, South Korea)
"The Balance of Top-Down and Bottom-Up Approaches in Aging and Longevity R&D"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 6:50 pmDavid Sinclair (Harvard Medical School, USA)
"What Studies Are Needed in Animals Before Moving to Human Trials?"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmRichard Miller (University of Michigan, USA)
"Optimized Designs for Picking and Testing Drugs that Slow Aging in Mice"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by R13AG050322 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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